User:Dianab
Diana Borenshtein
Bio
- postdoctoral fellow, laboratory of Prof. David Schauer
- Ph.D in Molecular and Systems Toxicology from Biological Engineereing Division, MIT2007, laboratory of Prof. David Schauer
- M. Sc. in Nutritional Sciences from The Hebrew University of Jerusalem, Faculty of Agricultural, Food and Environmental Quality Sciences, Israel1999
- B. Sc. in Nutritional Sciences from The Hebrew University of Jerusalem, Faculty of Agricultural, Food and Environmental Quality Sciences, Israel1994
Research
We recently discovered the different responses of related outbred SW and inbred FVB stocks of mice to the causative agent of transmissible murine colonic hyperplasia, Citrobacter rodentium. After biological characterization of the model of fatal colitis in FVB mice, I'm currently studying the host factors determining susceptibility to C. rodentium infection in colitis-prone and colitis-resistant animals. The results obtained from Microarray data are verified at different levels (real-time PCR, validation experiments, etc...). My other interests include studying genomic instability in murine colons, investigating the effect of bacterial infection in base excision repair deficient mice and other projects related to colon carcinogenesis.
Contact
MIT 56-786
diana_b@mit.edu
Publications
• Borenshtein D, Nambiar PR, Groff EB, Fox JG, Schauer DB. Development of fatal colitis in FVB mice infected with Citrobacter rodentium. Infect Immun, in Press, doi:10.1128/IAI.01810-06. (cover image in July issue).
• Borenshtein D, Schauer DB. The genus Citrobacter. In, M. Dworkin et al., eds., The Prokaryotes: An Evolving Electronic Resource for the Microbiological Community, 3rd edition, Springer-Verlag, New York (Release 3.18, 2004).
• Stark AH, Ilan E, Timar B, Borenshtein D, Madar Z. Alpha lipoic acid inhibits glycogen synthesis and modifies glucose metabolism and signaling pathways in soleus muscles from healthy rats. Nutraceuticals and Food 2002; 7: 113-118.
• Borenshtein D, Ofri R, Werman M, Stark A, Tritschler HJ, Moeller W, Madar Z. Cataract development in diabetic sand rats treated with alpha-lipoic acid and its gamma-linolenic acid conjugate. Diabetes Metab Res Rev 2001; 17: 44-50.
