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Transplant Tolerance Induction for Solid Organ Transplantation

GENERAL INFO • BASICS

SMALL RODENT General • Experiments

NONHUMAN PRIMATE • WHY NHPs?

HUMAN • History

News:

1/20/06 -- Transplant Tolerance Is being constructed.

NOTE: Transplant Tolerance is a place where you could find some introductory recent information on transplantation tolerance. It is currently prepared by one individual, therefore it is restricted in terms of rigorous verification and "recentness". You may contact me at morphomes at org. us know].

Experimental models

1. Studies in small rodents (mice, rats)
2. Studies in nonhuman primates

Immunosuppressor agens used

1. Antilymphocyte antisera: Antilymphocyte globulin, thymoglobulin, rituximab.
2. Immunosupressor drugs: Sirolimus, Tacrolimus

Adjuvant donor bone marrow (BM) infusion

1. Whole unfractionated BM infusion.
2. Fractionated BM infusion
3. Enriched BM progenitor cell infusion

"Laws of transplantation"

1. Transplants between inbred strains will succeed.
2. Transplants between inbred strains will fail,
3. Transplants from a member of an inbred parental strain to an F-1 offspring will succeed, but those in the reverse direction will fail.
4. Transplant from F2 and all subsequentt generations to F1 animals will succeed.
5. Transplants from inbred parental strains to the F2 generation will usually, but not always fail.