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'''This page is under construction, please come back later to check the most recent information.''' | |||
Transplant | |||
='''Transplant Tolerance Induction for Solid Organ Transplantation'''= | |||
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<div style="text-align: left;padding: .4em .9em .9em"> | |||
<h3>GENERAL INFO</h3> | |||
• [[BASICS]] <br> | |||
</div> | |||
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<div style="clear: right; text-align: left; float: left; padding: .4em .9em .9em"> | |||
<h3>SMALL RODENT</h3> | |||
• [[Experiments]]<br> | |||
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<div style="text-align: left; padding: .4em .9em .9em"> | |||
<h3>NONHUMAN PRIMATE</h3> | |||
• [[WHY NHPs?]]<br> | |||
</div> | |||
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<div style="text-align: left; padding: .4em .9em .9em"> | |||
<h3>HUMAN</h3> | |||
• [[History]]<br/> | |||
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<div style="text-align: left; padding: .4em .9em .9em"> | |||
<h3>Meta</h3> | |||
• [[About]]<br/> | |||
</div> | |||
|} | |||
<h2>News:</h2> | |||
1/20/06 -- [[Transplant Tolerance]] Is being constructed.<br> | |||
==Experimental models== | |||
# Studies in [[small rodents]] (mice, rats) | |||
# Studies in [[nonhuman primates]] | |||
==Immunosuppressor agens used== | |||
# Antilymphocyte antisera: Antilymphocyte globulin, thymoglobulin, rituximab. | |||
#Immunosupressor drugs: Sirolimus, Tacrolimus | |||
==Adjuvant donor bone marrow (BM) infusion== | |||
# Whole unfractionated BM infusion. | |||
# Fractionated BM infusion | |||
# Enriched BM progenitor cell infusion | |||
=="Laws of transplantation"== | =="Laws of transplantation"== | ||
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# Transplant from F2 and all subsequentt generations to F1 animals will succeed. | # Transplant from F2 and all subsequentt generations to F1 animals will succeed. | ||
# Transplants from inbred parental strains to the F2 generation will usually, but not always fail. | # Transplants from inbred parental strains to the F2 generation will usually, but not always fail. | ||
------------------------ | |||
NOTE: This website is a place where you could find some introductory recent information on transplantation tolerance. It is currently prepared by one individual, therefore it is restricted in terms of rigorous verification and "recentness". A mirror of this page is also beign built at [http://morphomes.org/transplantwiki TransplantWiki]. If you would like to contact me for anything please feel free to do so:[mailto:edipakpinar@morphomes.org e-mail_1]or [mailto:ea82@georgetown.edu e-mail_2]. | |||
Latest revision as of 06:06, 31 January 2006
This page is under construction, please come back later to check the most recent information.
Transplant Tolerance Induction for Solid Organ Transplantation
GENERAL INFO• BASICS |
SMALL RODENT |
NONHUMAN PRIMATE |
HUMAN• History |
Meta• About |
News:
1/20/06 -- Transplant Tolerance Is being constructed.
Experimental models
- Studies in small rodents (mice, rats)
- Studies in nonhuman primates
Immunosuppressor agens used
- Antilymphocyte antisera: Antilymphocyte globulin, thymoglobulin, rituximab.
- Immunosupressor drugs: Sirolimus, Tacrolimus
Adjuvant donor bone marrow (BM) infusion
- Whole unfractionated BM infusion.
- Fractionated BM infusion
- Enriched BM progenitor cell infusion
"Laws of transplantation"
- Transplants between inbred strains will succeed.
- Transplants between inbred strains will fail,
- Transplants from a member of an inbred parental strain to an F-1 offspring will succeed, but those in the reverse direction will fail.
- Transplant from F2 and all subsequentt generations to F1 animals will succeed.
- Transplants from inbred parental strains to the F2 generation will usually, but not always fail.
NOTE: This website is a place where you could find some introductory recent information on transplantation tolerance. It is currently prepared by one individual, therefore it is restricted in terms of rigorous verification and "recentness". A mirror of this page is also beign built at TransplantWiki. If you would like to contact me for anything please feel free to do so:e-mail_1or e-mail_2.
