User:Emmnanuel Quiroz: Difference between revisions
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==Education== | ==Education== | ||
== | ==Chernobyl Fungi Proposal== | ||
<!-- Feel free to add brief descriptions to your research interests as well --> | <!-- Feel free to add brief descriptions to your research interests as well --> | ||
# | ===Topic=== | ||
# | Recent studies have discovered fungal species that survive and proliferate in environments of ionizing radiation such as the Chernobyl reactor. These fungi have very efficient DNA repair gene systems that are homologous to Humans. These fungal systems need to be further studied and analyzed through microarrays to provide the possibly of radiation-based cancer therapies. | ||
# | ===Research Goals=== | ||
# Map the DNA repair system of these efficient fungal species | |||
# Compare the fungi system to that of Humans for possible radiation-based cancer therapies. | |||
===References=== | |||
# '''Ionizing radiation: how fungi cope, adapt, and exploit with the help of melanin''' | |||
Fungi are seen to proliferate in environments of ionizing radiation such as the Chernobyl reactor and on the outer shell of space craft. These fungi show an increase in melanin expression which suggest that melanin can function in energy capture and prevent DNA damage. It was also seen through microarray analysis that exposure to radiation caused an up regulation in DNA repair genes. Interestingly, many of the radiation resistance genes share significant homology with human genes that might be exploited in the development of novel radiation-based cancer therapies. | |||
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VS2-4TS239S-2&_user=501045&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000022659&_version=1&_urlVersion=0&_userid=501045&md5=facff3af8627e0e8bf35887a67b6bcab | |||
# '''Fungi and Ionizing Radiation from Radionuclides''' | |||
#http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VS2-4TS239S-2&_user=501045&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000022659&_version=1&_urlVersion=0&_userid=501045&md5=facff3af8627e0e8bf35887a67b6bcab | |||
===In the News=== | |||
#Einstein Researchers' Discovery of "Radiation-Eating" Fungi Could Trigger Recalculation of Earth's Energy Balance and Help Feed Astronauts | |||
==Publications== | ==Publications== | ||
Revision as of 14:31, 27 April 2009
I am a new member of OpenWetWare!
Contact Info
- Emmanuel Quiroz
- Biological Engineering
- 416 Beacon St
- Address 2
- Boston, MA, 02115
- equiroz AT mit DOT edu
I work in the Wittrup Lab at MIT. I learned about OpenWetWare from Class, and I've joined because To access my classes material.
Education
Chernobyl Fungi Proposal
Topic
Recent studies have discovered fungal species that survive and proliferate in environments of ionizing radiation such as the Chernobyl reactor. These fungi have very efficient DNA repair gene systems that are homologous to Humans. These fungal systems need to be further studied and analyzed through microarrays to provide the possibly of radiation-based cancer therapies.
Research Goals
- Map the DNA repair system of these efficient fungal species
- Compare the fungi system to that of Humans for possible radiation-based cancer therapies.
References
- Ionizing radiation: how fungi cope, adapt, and exploit with the help of melanin
Fungi are seen to proliferate in environments of ionizing radiation such as the Chernobyl reactor and on the outer shell of space craft. These fungi show an increase in melanin expression which suggest that melanin can function in energy capture and prevent DNA damage. It was also seen through microarray analysis that exposure to radiation caused an up regulation in DNA repair genes. Interestingly, many of the radiation resistance genes share significant homology with human genes that might be exploited in the development of novel radiation-based cancer therapies. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VS2-4TS239S-2&_user=501045&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000022659&_version=1&_urlVersion=0&_userid=501045&md5=facff3af8627e0e8bf35887a67b6bcab
- Fungi and Ionizing Radiation from Radionuclides
In the News
- Einstein Researchers' Discovery of "Radiation-Eating" Fungi Could Trigger Recalculation of Earth's Energy Balance and Help Feed Astronauts
Publications
- Goldbeter A and Koshland DE Jr. An amplified sensitivity arising from covalent modification in biological systems. Proc Natl Acad Sci U S A. 1981 Nov;78(11):6840-4. DOI:10.1073/pnas.78.11.6840 |
- JACOB F and MONOD J. Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol. 1961 Jun;3:318-56. DOI:10.1016/s0022-2836(61)80072-7 |
leave a comment about a paper here
- ISBN:0879697164
