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== Research ==
== Heather Etchevers ==
[[Image:Heather.jpg|frame]]
=== Official CV ===
[http://cvscience.aviesan.fr/cv/645/heather-corbett-etchevers This is the one] my workplace wants me to have in a standard format. It's up to date as of November, 2011.


=== Human neural crest cell differentiation ===
=== Short CV ===


Our current project concerns the transcriptional and phenotypic characterization of highly multipotent neural crest cells (NCC) derived from human embryos. Such characterization is a prerequisite to developing cell-based replacement therapies for congenital malformations or progressive diseases in which neural crest-derived lineages play a primary pathogenic role (“neurocristopathies”). Given their endogenous plasticity and shared heritage with neural stem cells, clinical applications for neural crest cells may prove to be even wider.  
<table border="0" cellspacing="15" cellpadding="2">
<tr bgcolor="#CCFFCC"> <td>1992  </td> <td>[http://www.wellesley.edu Wellesley College], Massachusetts (USA)</td> </tr>
<tr bgcolor="#CCFFCC"> <td>1998  </td> <td>Ph.D. [http://mcb.berkeley.edu/site/ University of California at Berkeley], California (USA)</td> </tr>
<tr bgcolor="#CCFFCC"> <td>1999  </td> <td>Ph.D. [http://www.upmc.fr/FR/info/00 Université Pierre et Marie Curie - Paris 6] (equivalence for France)</td> </tr>
<tr bgcolor="#CCFFCC"> <td>1999-2002  </td> <td>Postdoc with N. Le Douarin at the IECM, Nogent-sur-Marne, France</td> </tr>
<tr bgcolor="#CCFFCC"> <td>2002-2003  </td> <td>Postdoc with S. Lyonnet and M. Vekemans, INSERM, Necker Children’s Hospital, Paris, France</td> </tr>
<tr bgcolor="#CCFFCC"> <td>since 2003  </td> <td>Group leader (Avenir), Necker Children’s Hospital, Paris, France</td> </tr>
<tr bgcolor="#CCFFCC"> <td>2004  </td> <td>Chargé de recherche, [http://www.inserm.fr INSERM]</td> </tr>
</table>


A quantitative SAGE analysis of the entire set of mRNA transcripts derived from primary human NCC is currently underway in our laboratory, in order to establish an initial transcriptional profile of genes that distinguish the undifferentiated state for this cell type. The SAGE data will be supplemented with that from a different functional genomics tool that is being exploited in our parent research group in the INSERM U781 and with our collaborators at Institut Curie, custom and standardized Affymetrix DNA microarrays. Statistical analysis and comparison of the SAGE and microarray results using bioinformatics should permit us to class transcripts into functional clusters and identify groups of genes that are up- or down-regulated during NCC differentiation.
=== More stuff ===
''Where I've been to learn things:''
<table><table border="0" cellspacing="15" cellpadding="2">


In order to rapidly assess gene function, our group looks at the expression of candidate genes for certain neurocristopathies during normal human embryonic development using in situ hybridization on sections. We can also test the effects of gain or loss of gene function by targeting the NCC of the chicken embryo (a model with many technical advantages) using electroporation, and performing short- and long-term analyses.
<tr><td>1988</td> <td>'''Pathology Department''', Newton-Wellesley Hospital</td> <td>Massachusetts, USA</td></tr>


Over the long term, our group also plans to immortalize human NCC shortly after their initial migration, when they most resemble “true” stem cells in their potential. We will test the capacity of the cells to differentiate appropriately after transplantation in vivo into the developing chicken embryo. In this way, we can define the capacity of multipotent NCC to acquire diverse cell phenotypes in an appropriate environment. We also intend to carry out in vitro characterizations under varying culture conditions and compare the properties of transformed versus primary human cells.
<tr><td>1990</td> <td>'''Management Basics Program''', Wellesley College</td> <td>Massachusetts, USA</td></tr>


=== Différenciation de la crête neurale humaine ===
<tr><td>1990</td> <td>'''Summer Student Program''', The Jackson Laboratory</td> <td>Maine, USA</td></tr>


'' Notre projet concerne la caractérisation transcriptionnelle et phénotypique des cellules multipotentes de la crête neurale (CN) dérivée d’embryons humains. Cette recherche est indispensable avant d’envisager de développer des cytothérapies de remplacement pour des « neurocristopathies » congénitales ou progressives tels le syndrome de Hirschsprung ou certaines neuropathies périphériques. Vu la plasticité endogène de la CN et ses caractéristiques partagées avec les cellules souches neuronales, les applications cliniques pourraient s’avérer encore plus larges.''
<tr><td>1992</td> <td>'''Internationale Ferienkurse für Neue Musik''', Internationales Musikinstitut</td> <td>Darmstadt, Germany</td></tr>


'' Nous entreprenons d’immortaliser des lignées de CN humaine peu de temps après la migration initiale de ces cellules, quand ils ont le plus grand potentiel de différenciation. Nous allons tester la capacité des lignées de se différencier correctement in vivo chez l’embryon de poulet.
<tr><td>2002</td> <td>'''Course in Scientific Management''', Howard Hughes Medical Institute</td> <td>Maryland, USA</td></tr>
Une analyse quantitative SAGE du transcriptome entier des cellules CN humaines est en cours actuellement, afin d’établir le profil des gènes qui caractérisent l’état indifférencié de la CN.''  


'' Ensuite, nous corroborons ces résultats avec un autre outil de génomique fonctionnel, des puces Affymetrix fait sur mesure ou standards, utilisés par nos collaborateurs de l’équipe au sens plus large de l’INSERM U781 et à l’Institut Curie. Nous comparerons par exemple le profil transcriptionnel des ganglions fœtaux avec celui de leurs précurseurs multipotents. Une analyse statistique et une comparaison bio-informatique des résultats SAGE et microarray devrait nous permettre de classer les transcrits par groupes fonctionnels qui sont modulés au cours de la différenciation. ''
<tr><td>2004</td> <td>'''Personne Compétente en Radioprotection''', (Radiation Safety Officer qualification) Université Réné Descartes – Paris 5</td> <td>Paris, France</td></tr>
</table>
<p></p>


'' Afin d’évaluer rapidement la fonction de tels groupes, nous examinerons l’expression de gènes candidats pour des neurocristopathies humaines par l’hybridation in situ sur des coupes d’embryons humains normaux. Nous effectuerons aussi des gains ou pertes de fonction de ces gènes au sein de la CN de l’embryon de poulet afin de voir l’effet sur sa différenciation dans un environnement approprié. Ainsi, nous espérons identifier des nouveaux gènes responsables de neurocristopathies ainsi que de connaître leurs modes de fonctionnement qui pourront mener à des voies thérapeutiques.''
<p>''Awards and Distinctions''</p>
 
<p>Programme Avenir, Institut National de la Santé et de la Recherche Médicale 2002-2005</p>
<p>Predoctoral Fellow in the Biological Sciences, Howard Hughes Medical Institute 1993-1998</p>
<p>Director, Conseil Médico-Scientifique de l’Association Naevus 2000 France-Europe depuis 1999</p>
<p>Phi Beta Kappa (humanities) and Sigma Xi (sciences) since 1992</p>
<p></p>
 
[[Image:Mendeley-Advisor-button-blue_2495708292830221.png]] http://www.mendeley.com/profiles/heather-etchevers/
 
<p>''Conference organization''</p>
 
<p>Organizer : “ The congenital giant nevus : research and treatment. ” Satellite symposium for the 18th International Pigment Cell Conference, Egmond-aan-See (Pays-Bas), 13-sept-2002</p>
<p>Session moderator, scientific committee : « Congrès Jeunes Chercheurs de l’Université Paris V», Paris, 19-oct-'''2005''' (and '''2006''', to '''2008''')</p>
<p>Moderator, scientific committee :  « Naevus Géant Congénital, les soins et la recherche associée » Marne-la-Vallée, 12-nov-2005</p>
<p>Moderator, scientific committee : « Quelles thérapies innovantes développer dans la prochaine décennie pour soigner le NGC ?»  Vichy, 14-nov-2009</p>
<p></p>
<p></p>
 
=== Publication list on [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?holding=&db=PubMed&cmd=search&term=etchevers%20h/ PubMed] ===
 
=== Nearly if not all my publications are downloadable from [http://www.mendeley.com/profiles/heather-etchevers/ my Mendeley profile] ===
 
=== [http://www.linkedin.com/in/etchevers Click on this text for my profile on [[Image:Linkedin_120x30.gif]] ]===
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<p>This image takes the common words out of some of my publications, including the [http://humans.scienceboard.net blogs] that I've [http://blogs.nature.com/etchevers/ stopped posting to] for the time being. You can go over to [http://www.wordle.net/ Wordle] and play, too, though.
[[Image:Word_cloud_HIS.jpg]]</p>
 
[mailto:heather.etchevers@inserm.fra E-mail me but erase the final "a".] This address is equivalent to the old, defunct server '''etchever@infobiogen.fr''' which figures on some of the older publications - most of which are open access anyhow.
 
 
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=== [[Etchevers_Lab| Back to lab page]] ===
 
--[[User:Etchevers|Heather]] 09:27, 2 November 2011 (EDT)
 
[[Category:User France]]

Latest revision as of 01:35, 14 February 2012

Heather Etchevers

Official CV

This is the one my workplace wants me to have in a standard format. It's up to date as of November, 2011.

Short CV

1992 Wellesley College, Massachusetts (USA)
1998 Ph.D. University of California at Berkeley, California (USA)
1999 Ph.D. Université Pierre et Marie Curie - Paris 6 (equivalence for France)
1999-2002 Postdoc with N. Le Douarin at the IECM, Nogent-sur-Marne, France
2002-2003 Postdoc with S. Lyonnet and M. Vekemans, INSERM, Necker Children’s Hospital, Paris, France
since 2003 Group leader (Avenir), Necker Children’s Hospital, Paris, France
2004 Chargé de recherche, INSERM

More stuff

Where I've been to learn things:

1988 Pathology Department, Newton-Wellesley Hospital Massachusetts, USA
1990 Management Basics Program, Wellesley College Massachusetts, USA
1990 Summer Student Program, The Jackson Laboratory Maine, USA
1992 Internationale Ferienkurse für Neue Musik, Internationales Musikinstitut Darmstadt, Germany
2002 Course in Scientific Management, Howard Hughes Medical Institute Maryland, USA
2004 Personne Compétente en Radioprotection, (Radiation Safety Officer qualification) Université Réné Descartes – Paris 5 Paris, France

Awards and Distinctions

Programme Avenir, Institut National de la Santé et de la Recherche Médicale 2002-2005

Predoctoral Fellow in the Biological Sciences, Howard Hughes Medical Institute 1993-1998

Director, Conseil Médico-Scientifique de l’Association Naevus 2000 France-Europe depuis 1999

Phi Beta Kappa (humanities) and Sigma Xi (sciences) since 1992

http://www.mendeley.com/profiles/heather-etchevers/

Conference organization

Organizer : “ The congenital giant nevus : research and treatment. ” Satellite symposium for the 18th International Pigment Cell Conference, Egmond-aan-See (Pays-Bas), 13-sept-2002

Session moderator, scientific committee : « Congrès Jeunes Chercheurs de l’Université Paris V», Paris, 19-oct-2005 (and 2006, to 2008)

Moderator, scientific committee : « Naevus Géant Congénital, les soins et la recherche associée » Marne-la-Vallée, 12-nov-2005

Moderator, scientific committee : « Quelles thérapies innovantes développer dans la prochaine décennie pour soigner le NGC ?» Vichy, 14-nov-2009

Publication list on PubMed

Nearly if not all my publications are downloadable from my Mendeley profile

Click on this text for my profile on


This image takes the common words out of some of my publications, including the blogs that I've stopped posting to for the time being. You can go over to Wordle and play, too, though.

E-mail me but erase the final "a". This address is equivalent to the old, defunct server etchever@infobiogen.fr which figures on some of the older publications - most of which are open access anyhow.


Back to lab page

--Heather 09:27, 2 November 2011 (EDT)

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