User:Etchevers/Notebook/Conference notes/2009/09/13: Difference between revisions
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The folate-sensitive NTDs are now being protected in the US at least. Other nutrients in supplements can be helpful in theory but have not seen a stronger association. For example, subsequent to fortification, NTDs did not go down in the CA Central valley region. | The folate-sensitive NTDs are now being protected in the US at least. Other nutrients in supplements can be helpful in theory but have not seen a stronger association. For example, subsequent to fortification, NTDs did not go down in the CA Central valley region. | ||
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from Hank: Low choline risk in another study - in blood the levels are related to those of folate. Also, wonder about serine and something else I didn't catch. | |||
*'''[[User:Etchevers|Heather]] 09:02, 13 September 2009 (EDT)''': | *'''[[User:Etchevers|Heather]] 09:02, 13 September 2009 (EDT)''': | ||
Revision as of 06:04, 13 September 2009
 Conference and seminar notes
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Second day of 6th Intl Neural Tube Defects conferenceDania Pastora, NTDs in Nicaragua 2007-8NTD most common CM in Nicaragua, registry started in 2007. NW Ncaragua - Leon and Chinandega For 20K newborns in two years, 800 stillborn, 495 CM's (2.5%) and 43 NTD. No sex bias. NTDs in stillborn = 9/800 (112/10K) and others = 34/19200 (18/10000). SB most frequent, more in males (9 vs 1 for meningocoele (half dead but from another cause - premature for 3 or respiratory distress); 8 vs 11 for myelomeningocoele (4 dead from surgical complications); 2 cases of encephalocoele and 19 anencephales - where the last have no sex bias). 14% mothers took folic acid and only in 2nd trimester. Supplementation not regulated by health authorities. Damn - my battery did not recharge overnight for some reason!! Will take notes on paper and recopy later.
Suzan Carmichael - nutrient intake and risks of NTDs in CaliforniaMosley 2009 - births after folic acid supplementation only study actually found increase in anencephaly. Contribute data to Mosley study also the CA cohort (part of national birth defect study). Oxidative stress nutrients and anencephaly Lutein (caratenoid?) - odds ratio 1 = no association for first quartile (low intake) and last quartile (high) Vit C - low intake OR = 3.2, high intake protective (-0.6) restricted to women w/o supplements - trend was significant. Vit E OR = 1.4, protective 0.5 with wide CI but trend was significant. b-carotene, low intake slightly protective, high intake v protective (0.2) and for iron - high intake increased risk to 2.5 (as a pro-oxidant... but in light of I Zohn's talk wonders what to think now). One-carbon nutrients and anencephaly Methioninem choline, betaine no differences, folate expected and riboflavin low intake increased risk but high intake brought back to normal. This was exaggerated for spina bifida except unexpected methionine. Thiamin and zinc were opposite - esp high zinc intake OR up to 4 for anencephaly, not very significant trends for spina bifida. Glycemic index - higher index expected increased risk but not found, not for other simple sugars - fructose, glucose or sucrose. Is there a ceiling effect of supplementation? *Supplements are weakly if at all protective.* The folate-sensitive NTDs are now being protected in the US at least. Other nutrients in supplements can be helpful in theory but have not seen a stronger association. For example, subsequent to fortification, NTDs did not go down in the CA Central valley region. Question: from Hank: Low choline risk in another study - in blood the levels are related to those of folate. Also, wonder about serine and something else I didn't catch.
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