User:Tkadm30/Notebook/Aripiprazole

Functional selectivity of aripiprazole at D2 receptors

• Aripiprazole has functionally selective actions at dopamine D2 receptor-mediated signaling pathways.
• Protective effect of aripiprazole against glutamate cytotoxicity in dopaminergic neurons of rat mesencephalic cultures.
• Antagonism of the adenosine A2A receptor attenuates akathisia-like behavior induced with MP-10 or aripiprazole in a novel non-human primate model.
• Repeated aripiprazole treatment causes dopamine D2 receptor up-regulation and dopamine supersensitivity in young rats.
• Unique Effects of Acute Aripiprazole Treatment on the Dopamine D2 Receptor Downstream cAMP-PKA and Akt-GSK3β Signalling Pathways in Rats
• Chronic administration of aripiprazole activates GSK3β-dependent signalling pathways, and up-regulates GABAA receptor expression and CREB1 activity in rats

Aripiprazole/THC interactions

• Aripiprazole-CB1 activation may increase functional selectivity at dopamine D2 receptors? (Reference needed)
• Effects of Aripiprazole and Haloperidol on Fos-like Immunoreactivity in the Prefrontal Cortex
• https://www.mrnice.nl/forum/9-patients-forum/15829-aripiprazole-thc-interactions.html

Aripiprazole-mediated gene expression

• Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism.

Side effects

• Worsened hypertension control induced by aripiprazole
• Dopamine supersensitivity psychosis and dopamine partial agonist: a retrospective survey of failure of switching to aripiprazole in schizophrenia.
• Akathisia
• Insomnia
• Tardive dyskinesia
• Racing thoughts
• Hyperdreaming

Notes

• Is Aripiprazole a selective FAAH inhibitor?

See also

• AKT1 Notebook
• FAAH Notebook
• THC Notebook