User:Etienne Robillard/Notebook/Arylcyclohexylamines

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__TOC__
__TOC__
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== Overview ==
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== Introduction ==
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Methylphenidate (trademark Ritalin) HCl is a piperidine derived synthetic drug prescribed in the treatment of schizophrenia and
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Methylphenidate (trademark Ritalin) HCl is a [[piperidine|piperidine]] derived synthetic drug prescribed in the treatment of schizophrenia and
autistic disorders to childrens with chronic ADHD (Attention Deficit Hyperactivity Disorder) symptoms.  
autistic disorders to childrens with chronic ADHD (Attention Deficit Hyperactivity Disorder) symptoms.  
-
=== Amphetamine-induced psychosis: The business of mental addiction to amphetamine drugs is poorly understood in the tragedy of Sandy Hook. ===
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The purpose of this document is to investigate the whys and wherefores of Agent Scooby Doo in the product of cyclohexylamine induced reactions
 +
by comparitive study of psychotropic alkylamines drugs including Methylphenidate and Arylacetonitriles-derived alkylating solvents and their combined effects on
 +
human NMDA receptor.
 +
 
 +
Also the study of PCP derived piperidine analog compounds will be beneficial in the proper understanding of synthetic drug abuses and
 +
to prevent future disasters by chemical aerosol spraying prohibition and legislation.
 +
 
 +
== Psychotropic alkylamines ==
 +
 
 +
=== cyclohexylamines, methamphetamine, and methylphenidate ===
 +
 
 +
==== Methylphenidate (Ritalin) ====
Methylphenidate compound is synthetically comparable to amphetamine-class drug (cocaine), by functioning as a long-term dopamine
Methylphenidate compound is synthetically comparable to amphetamine-class drug (cocaine), by functioning as a long-term dopamine
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drug abuses including altered state of behavior, paranoia, and depression.  
drug abuses including altered state of behavior, paranoia, and depression.  
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=== Discuss ===
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=== N-substituted psychotropic alkylamines derivatives implicated in organic synthesis of orthogonal phosphoramides  ===
 +
 
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* Documentation:
 +
** http://en.wikipedia.org/wiki/Phase-transfer_catalysis
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** http://en.wikipedia.org/wiki/Amide
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** http://euch6f.chem.emory.edu/arynes.html
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** [http://www.chemguide.co.uk/organicprops/anhydrides/nitrogen.html Reactions of Ketones with Primary Amines]
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** http://research.cm.utexas.edu/nbauld/CHAPTER%2021.htm
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==== Arylcyclohexylamines and N-substituted cyclohexylaminopyrimidines derivatives ====
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* Aryl ketones (4-trans substituted cyclohexylamines and 4-methoxy derived compounds)
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** 4-hydroxymethyl-1-aryl-cyclohexylamine : US7232847
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* "Certain 2-(2-substituted benzoyl)-1,3-cyclohexanediones": http://www.freepatentsonline.com/EP0090262.html
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* "phosphines" and the [[Phosphohistidine_transferase|phosphohistidine transferase]] enzyme.
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** phosphoramidate based peptide and oligo "coupling" reagents...
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* N-substituted cyclohexylaminopyrimidines:
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** E. coli K-12 W3110 (aka the pyrimidine starved strain...)
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** [http://openwetware.org/wiki/OSDDMalaria:GSK_Amino-thienopyrimidine_Series GSK Amino thienopyrimidine series]
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*** See US5039692 - '''[http://openwetware.org/wiki/User:Etienne_Robillard/Notebook/Fmoc_protected_phenoxyalkylamine_synthesis Psychotropic phenoxyalkylamine derivatives and their uses in domestic/civilian experiments with synthetic opioid receptor agonists]''' (1,2-substituted thienopyrimidone)
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*** See http://en.wikipedia.org/wiki/Sulfanilamide - A compound which has been listed in the Doctor Trials of the Nuremberg nazi medical experiments [http://law2.umkc.edu/faculty/projects/ftrials/nuremberg/NurembergDoctorTrial.html 1]
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* Keywords:
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** cyanoethylation,arylcyclohexylamine,phosphoramidate,succinic acid,arynes(1,2-substituted arenes)
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=== Tetrahydroisoquinolines derivatives === 
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==== 4,7-dichloroquinoline ====
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* consciousness here.
 
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* mind control and abuse of pharmacological substances (PCP, Ketamine, Methylphenidate, etc)
 
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* protecting childrens by educating them about self-control and philosophy.
 
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* self defense from staged events: how do we draw a line as a free society from passivity (spectators) to non-permissive actors?
 
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* when is journalism accomplice to mass murders in demolishing evidences with demagogy and deliberate incompetency ?
 
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* Emmanuel Kant?
 
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* Suite 8F group "Georgetown Crowd”
 
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* Bill Clinton, Bones Club, Before Christ, British Columbia
 
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* Steve Kangas
 
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* http://educationforum.ipbhost.com/index.php?showtopic=5142
 
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* http://www.spartacus.schoolnet.co.uk/JFKmockingbird.htm
 
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* Katharine Graham (Deborah Davis) "We live in a dirty and dangerous world. There are some things the general public does not need to know and shouldn't. I believe democracy flourishes when the government can take legitimate steps to keep its secrets and when the press can decide whether to print what it knows."
 
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* Allen Dulles http://www.spartacus.schoolnet.co.uk/USAdullesA.htm
 
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* Yale University (new haven, Connecticut)
 
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* Scull (A fast gliding boat)
 
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* Wantagate/Operation Double-Cross : [[http://tekgnosis.typepad.com/tekgnosis/2008/03/lee-emil-wantaw.html#13561377322521&action=collapse_widget&id=8923399, 1]], [[http://dastych.wordpress.com/2010/01/18/the-case-of-ambassador-leo-emil-wanta/ 2]]
 
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** "'''Although Wanta had no idea what The Children’s Defense Fund was all about, a financial investigator, Marco Saba of the Organized Crime Observatory in Switzerland, later wrote about it. It was a secret fund: “One component of this information concerns the activities of the CIA operative known as Mrs. Hillary Rodham Clinton.'''"
 
* Psychotropic alkylamines induced '''dermatitis''' -> [http://www.sigmaaldrich.com/catalog/product/aldrich/d74002?lang=en&region=SE 4,7-dichloroquinoline]
* Psychotropic alkylamines induced '''dermatitis''' -> [http://www.sigmaaldrich.com/catalog/product/aldrich/d74002?lang=en&region=SE 4,7-dichloroquinoline]
** Airborne agents causing reaction with micro wave irradiation? (ie: a wireless connection)
** Airborne agents causing reaction with micro wave irradiation? (ie: a wireless connection)
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** an anti-malarial compound;
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** An anti-malarial compound? (quinoline)
** NMDA antagonist?
** NMDA antagonist?
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** See http://www.ncbi.nlm.nih.gov/pubmed/6213361
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** http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0536.1982.tb04215.x/abstract
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** US Patent Application: 20110281844 ("NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS")
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** http://blogs.ch.cam.ac.uk/pmr/files/2012/12/121712_1039_AMI2Content5.png
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*** see http://blogs.ch.cam.ac.uk
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*** see [http://loinen.i2p.to/rhodium/chemistry/future_drugs.html Future Synthetic Drugs of Abuses]
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=== References ===
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==== Taking the Yb(OTf)3 road to Sandy Hook ====
 +
 
 +
* [[User:Etienne Robillard|Etienne Robillard]] 11:18, 19 January 2013 (EST) Also interesting, the evidences towards '''microwave-triggered 1,2,3,4-substituted tetrahydroisoquinolines''' suggests a orthogonal and quite efficient route for psychotropic alkylamine catalysis using '''Yb(OTf)3''' gold nanoparticles as chiral (N-substituted) enamine ligand.... See also the "Stork-Enamine" and "Pictet-Spingler" reactions. [http://www.ourexperiment.org/racemic_pzq/5755 1]
 +
* [[User:Etienne Robillard|Etienne Robillard]] 08:17, 21 January 2013 (EST) In addition, single P-N enantiomers (enamide) can be fused into [http://www.thesynapticleap.org/node/328 aromatic heterocycle ring systems] in a reaction known as [http://www.openwetware.org/wiki/Todd:Asymmetric_Hydrogenation_of_PZQ_Enamide asymmetric hydrogenation]. See also [[Carboxamide]], a sulfonamide like carbonic anhydrase inhibitor to block in humans the catalysis of carbonic acid from infectious parasites like P. falciparum, a parasitic worm, thus preventing further cellular respiration to occur.  [Related: [https://en.wikipedia.org/wiki/Asymmetric_hydrogenation 1], Malaria, Mefloquine, Carbonic anhydrase] [doi:10.1016/S221-1691(11)60034-8]
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* [[User:Etienne Robillard|Etienne Robillard]] 11:07, 22 January 2013 (EST) '''Hence, did neuroscience student James Holmes took anti-malarial drug before opening fire in Sandy Hook theater and commiting mass murder of Afghanistan childrens?'''
 +
** [[User:Etienne Robillard|Etienne Robillard]] 11:07, 22 January 2013 (EST) In my understanding, the evidences for microwave-triggered (MW) peptide synthesis may provide to crime-scene investigators (CSI) additional evidences to confirm the role of '''Yb(OTf)3''' as an important factor (organocatalyst) in gold-mediated nanoparticles '''drug delivery''', thus a poorly-documented portrait of synthetic biology may emerge in the understanding of common denominators corroborated from theses cases of recent gun shooting into civilian, gun-free zones (schools, theaters, malls, etc).
 +
* [[User:Etienne Robillard|Etienne Robillard]] 08:36, 23 January 2013 (EST) How many watts of output can generate a single wireless device (ie Iphone) and is this energy input sufficient to catalyze '''Yb(OTf)3-mediated substrate''' (a Michael acceptor) in a controlled manner, assuming MW-triggered peptide synthesis has faster reactions time than SPPS to deliver anti-malarial drugs?
 +
 
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== See also ==
* http://en.wikipedia.org/wiki/Amphetamine
* http://en.wikipedia.org/wiki/Amphetamine
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* http://learn.genetics.utah.edu/content/addiction/issues/ritalin.html
* http://learn.genetics.utah.edu/content/addiction/issues/ritalin.html
* http://www.veteranstoday.com/2012/12/20/sandy-hook-massacre-official-story-spins-out-of-control/
* http://www.veteranstoday.com/2012/12/20/sandy-hook-massacre-official-story-spins-out-of-control/
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* http://www.cbc.ca/news/canada/story/2012/04/10/malaria-drug-mefloquine.html
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* http://alpha.chem.umb.edu/chemistry/ch471/documents/Microwave_Assisted_Peptide_Synthesis.pdf
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=== Dedication ===
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== Dedication ==
This page is dedicated to victims of Sandy Hook mass murder which occured on December 14 2012. May our creator give recomfort to the victims of theses uncivilised  
This page is dedicated to victims of Sandy Hook mass murder which occured on December 14 2012. May our creator give recomfort to the victims of theses uncivilised  
murdering acts and theses tragedies never be forgotten to identify and resolve the problems in our own life which leaded to such horror scenes. -[[User:Etienne Robillard|Etienne Robillard]] 09:50, 20 December 2012 (EST)
murdering acts and theses tragedies never be forgotten to identify and resolve the problems in our own life which leaded to such horror scenes. -[[User:Etienne Robillard|Etienne Robillard]] 09:50, 20 December 2012 (EST)
 +
 +
== References ==
 +
 +
* Reference 1
 +
* Reference 2
 +
* 4-(trans)-N-substituted arylcyclohexylamines derived compounds : US7977370, US5622916, US5032616, US4073942, US4113777,US4312861, US3536713, US3336308, US6071966, US5270340, US4595759
 +
* Substituted cyclohexylaminopyrimidines derivatives: US5723450, [http://www.google.com/patents/US6197729 US6197729], US6683027
 +
 +
== Bibliography ==
 +
<biblio>
 +
#Rueping-Boris-J-Nachtsheim-Beilstein-J-Org-Chem-2010 pmid=20485588
 +
</biblio>
 +
 +
== Glossary ==
 +
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* Ring Systems http://www.chem.qmul.ac.uk/iupac/class/rings.html
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* Nitrogen  http://www.chem.qmul.ac.uk/iupac/class/oneN.html
[[Category:Chemical]]
[[Category:Chemical]]
[[Category:Psychochemical]]
[[Category:Psychochemical]]

Revision as of 15:42, 23 January 2013

Contents


Introduction

Methylphenidate (trademark Ritalin) HCl is a piperidine derived synthetic drug prescribed in the treatment of schizophrenia and autistic disorders to childrens with chronic ADHD (Attention Deficit Hyperactivity Disorder) symptoms.

The purpose of this document is to investigate the whys and wherefores of Agent Scooby Doo in the product of cyclohexylamine induced reactions by comparitive study of psychotropic alkylamines drugs including Methylphenidate and Arylacetonitriles-derived alkylating solvents and their combined effects on human NMDA receptor.

Also the study of PCP derived piperidine analog compounds will be beneficial in the proper understanding of synthetic drug abuses and to prevent future disasters by chemical aerosol spraying prohibition and legislation.

Psychotropic alkylamines

cyclohexylamines, methamphetamine, and methylphenidate

Methylphenidate (Ritalin)

Methylphenidate compound is synthetically comparable to amphetamine-class drug (cocaine), by functioning as a long-term dopamine regulator, however its long-term effects on the developmental area of the brain is controversed and poorly understood by the scientific community. [1]

Moreover, chronic Ritalin use may in addition elevate the risks of amphetamine-induced psychosis, a notable side-effect in chronic amphetamine users. Overmedication with amphetamine-type drug is thus an additional concern to assess in the psychotherapy of childrens with amphetamine-like drugs. [2]

Amphetamine-induced psychosis may implicate as well severe hallucinations and other landmarks of long-term drug abuses including altered state of behavior, paranoia, and depression.

N-substituted psychotropic alkylamines derivatives implicated in organic synthesis of orthogonal phosphoramides

Arylcyclohexylamines and N-substituted cyclohexylaminopyrimidines derivatives

Tetrahydroisoquinolines derivatives

4,7-dichloroquinoline

Taking the Yb(OTf)3 road to Sandy Hook

  • Etienne Robillard 11:18, 19 January 2013 (EST) Also interesting, the evidences towards microwave-triggered 1,2,3,4-substituted tetrahydroisoquinolines suggests a orthogonal and quite efficient route for psychotropic alkylamine catalysis using Yb(OTf)3 gold nanoparticles as chiral (N-substituted) enamine ligand.... See also the "Stork-Enamine" and "Pictet-Spingler" reactions. 1
  • Etienne Robillard 08:17, 21 January 2013 (EST) In addition, single P-N enantiomers (enamide) can be fused into aromatic heterocycle ring systems in a reaction known as asymmetric hydrogenation. See also Carboxamide, a sulfonamide like carbonic anhydrase inhibitor to block in humans the catalysis of carbonic acid from infectious parasites like P. falciparum, a parasitic worm, thus preventing further cellular respiration to occur. [Related: 1, Malaria, Mefloquine, Carbonic anhydrase] [doi:10.1016/S221-1691(11)60034-8]
  • Etienne Robillard 11:07, 22 January 2013 (EST) Hence, did neuroscience student James Holmes took anti-malarial drug before opening fire in Sandy Hook theater and commiting mass murder of Afghanistan childrens?
    • Etienne Robillard 11:07, 22 January 2013 (EST) In my understanding, the evidences for microwave-triggered (MW) peptide synthesis may provide to crime-scene investigators (CSI) additional evidences to confirm the role of Yb(OTf)3 as an important factor (organocatalyst) in gold-mediated nanoparticles drug delivery, thus a poorly-documented portrait of synthetic biology may emerge in the understanding of common denominators corroborated from theses cases of recent gun shooting into civilian, gun-free zones (schools, theaters, malls, etc).
  • Etienne Robillard 08:36, 23 January 2013 (EST) How many watts of output can generate a single wireless device (ie Iphone) and is this energy input sufficient to catalyze Yb(OTf)3-mediated substrate (a Michael acceptor) in a controlled manner, assuming MW-triggered peptide synthesis has faster reactions time than SPPS to deliver anti-malarial drugs?

See also

Dedication

This page is dedicated to victims of Sandy Hook mass murder which occured on December 14 2012. May our creator give recomfort to the victims of theses uncivilised murdering acts and theses tragedies never be forgotten to identify and resolve the problems in our own life which leaded to such horror scenes. -Etienne Robillard 09:50, 20 December 2012 (EST)

References

  • Reference 1
  • Reference 2
  • 4-(trans)-N-substituted arylcyclohexylamines derived compounds : US7977370, US5622916, US5032616, US4073942, US4113777,US4312861, US3536713, US3336308, US6071966, US5270340, US4595759
  • Substituted cyclohexylaminopyrimidines derivatives: US5723450, US6197729, US6683027

Bibliography

  1. Rueping M and Nachtsheim BJ. . pmid:20485588. PubMed HubMed [Rueping-Boris-J-Nachtsheim-Beilstein-J-Org-Chem-2010]

Glossary

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