User:Etienne Robillard/Notebook/Arylcyclohexylamines

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* [[User:Etienne Robillard|Etienne Robillard]] 11:18, 19 January 2013 (EST) Also interesting, the evidences towards '''microwave-triggered 1,2,3,4-substituted tetrahydroisoquinolines''' suggests a orthogonal and quite efficient route for psychotropic alkylamine catalysis using '''Yb(OTf)3''' gold nanoparticles as chiral (N-substituted) enamine ligand.... See also the "Stork-Enamine" and "Pictet-Spingler" reactions. [http://www.ourexperiment.org/racemic_pzq/5755 1]
* [[User:Etienne Robillard|Etienne Robillard]] 11:18, 19 January 2013 (EST) Also interesting, the evidences towards '''microwave-triggered 1,2,3,4-substituted tetrahydroisoquinolines''' suggests a orthogonal and quite efficient route for psychotropic alkylamine catalysis using '''Yb(OTf)3''' gold nanoparticles as chiral (N-substituted) enamine ligand.... See also the "Stork-Enamine" and "Pictet-Spingler" reactions. [http://www.ourexperiment.org/racemic_pzq/5755 1]
* [[User:Etienne Robillard|Etienne Robillard]] 08:17, 21 January 2013 (EST) In addition, single P-N enantiomers (enamide) can be fused into [http://www.thesynapticleap.org/node/328 aromatic heterocycle ring systems] in a reaction known as [http://www.openwetware.org/wiki/Todd:Asymmetric_Hydrogenation_of_PZQ_Enamide asymmetric hydrogenation]. See also [[Carboxamide]], a sulfonamide like carbonic anhydrase inhibitor to block in humans the catalysis of carbonic acid from infectious parasites like P. falciparum, a parasitic worm, thus preventing further cellular respiration to occur.  [Related: [https://en.wikipedia.org/wiki/Asymmetric_hydrogenation 1], Malaria, Mefloquine, Carbonic anhydrase] [doi:10.1016/S221-1691(11)60034-8]
* [[User:Etienne Robillard|Etienne Robillard]] 08:17, 21 January 2013 (EST) In addition, single P-N enantiomers (enamide) can be fused into [http://www.thesynapticleap.org/node/328 aromatic heterocycle ring systems] in a reaction known as [http://www.openwetware.org/wiki/Todd:Asymmetric_Hydrogenation_of_PZQ_Enamide asymmetric hydrogenation]. See also [[Carboxamide]], a sulfonamide like carbonic anhydrase inhibitor to block in humans the catalysis of carbonic acid from infectious parasites like P. falciparum, a parasitic worm, thus preventing further cellular respiration to occur.  [Related: [https://en.wikipedia.org/wiki/Asymmetric_hydrogenation 1], Malaria, Mefloquine, Carbonic anhydrase] [doi:10.1016/S221-1691(11)60034-8]
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* [[User:Etienne Robillard|Etienne Robillard]] 11:07, 22 January 2013 (EST) '''Hence, did neuroscience student James Holmes took anti-malarial drug before opening fire in Sandy Hook theater and commiting mass murder of Afghanistan childrens?'''
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** [[User:Etienne Robillard|Etienne Robillard]] 11:07, 22 January 2013 (EST) In my understanding, the evidences for microwave-triggered (MW) peptide synthesis may provide to crime-scene investigators (CSI) additional evidences to confirm the role of '''Yb(OTf)3''' as an important factor (organocatalyst) in gold-mediated nanoparticles '''drug delivery''', thus a poorly-documented portrait of synthetic biology may emerge in the understanding of common denominators corroborated from theses cases of recent gun shooting into civilian, gun-free zones (schools, theaters, malls, etc).
 +
* [[User:Etienne Robillard|Etienne Robillard]] 08:36, 23 January 2013 (EST) How many watts of output can generate a single wireless device (ie Iphone) and is this energy input sufficient to catalyze '''Yb(OTf)3-mediated substrate''' (a Michael acceptor) in a controlled manner, assuming MW-triggered peptide synthesis has faster reactions time than SPPS to deliver anti-malarial drugs?
== See also ==
== See also ==
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* http://learn.genetics.utah.edu/content/addiction/issues/ritalin.html
* http://learn.genetics.utah.edu/content/addiction/issues/ritalin.html
* http://www.veteranstoday.com/2012/12/20/sandy-hook-massacre-official-story-spins-out-of-control/
* http://www.veteranstoday.com/2012/12/20/sandy-hook-massacre-official-story-spins-out-of-control/
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* http://www.cbc.ca/news/canada/story/2012/04/10/malaria-drug-mefloquine.html
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* http://alpha.chem.umb.edu/chemistry/ch471/documents/Microwave_Assisted_Peptide_Synthesis.pdf
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* [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation Imine (Schiff base) formation]
== Dedication ==
== Dedication ==
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* 4-(trans)-N-substituted arylcyclohexylamines derived compounds : US7977370, US5622916, US5032616, US4073942, US4113777,US4312861, US3536713, US3336308, US6071966, US5270340, US4595759
* 4-(trans)-N-substituted arylcyclohexylamines derived compounds : US7977370, US5622916, US5032616, US4073942, US4113777,US4312861, US3536713, US3336308, US6071966, US5270340, US4595759
* Substituted cyclohexylaminopyrimidines derivatives: US5723450, [http://www.google.com/patents/US6197729 US6197729], US6683027
* Substituted cyclohexylaminopyrimidines derivatives: US5723450, [http://www.google.com/patents/US6197729 US6197729], US6683027
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== Bibliography ==
 +
<biblio>
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#Rueping-Boris-J-Nachtsheim-Beilstein-J-Org-Chem-2010 pmid=20485588
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</biblio>
== Glossary ==
== Glossary ==

Revision as of 11:35, 31 January 2013

Contents


Introduction

Methylphenidate (trademark Ritalin) HCl is a piperidine derived synthetic drug prescribed in the treatment of schizophrenia and autistic disorders to childrens with chronic ADHD (Attention Deficit Hyperactivity Disorder) symptoms.

The purpose of this document is to investigate the whys and wherefores of Agent Scooby Doo in the product of cyclohexylamine induced reactions by comparitive study of psychotropic alkylamines drugs including Methylphenidate and Arylacetonitriles-derived alkylating solvents and their combined effects on human NMDA receptor.

Also the study of PCP derived piperidine analog compounds will be beneficial in the proper understanding of synthetic drug abuses and to prevent future disasters by chemical aerosol spraying prohibition and legislation.

Psychotropic alkylamines

cyclohexylamines, methamphetamine, and methylphenidate

Methylphenidate (Ritalin)

Methylphenidate compound is synthetically comparable to amphetamine-class drug (cocaine), by functioning as a long-term dopamine regulator, however its long-term effects on the developmental area of the brain is controversed and poorly understood by the scientific community. [1]

Moreover, chronic Ritalin use may in addition elevate the risks of amphetamine-induced psychosis, a notable side-effect in chronic amphetamine users. Overmedication with amphetamine-type drug is thus an additional concern to assess in the psychotherapy of childrens with amphetamine-like drugs. [2]

Amphetamine-induced psychosis may implicate as well severe hallucinations and other landmarks of long-term drug abuses including altered state of behavior, paranoia, and depression.

N-substituted psychotropic alkylamines derivatives implicated in organic synthesis of orthogonal phosphoramides

Arylcyclohexylamines and N-substituted cyclohexylaminopyrimidines derivatives

Tetrahydroisoquinolines derivatives

4,7-dichloroquinoline

Taking the Yb(OTf)3 road to Sandy Hook

  • Etienne Robillard 11:18, 19 January 2013 (EST) Also interesting, the evidences towards microwave-triggered 1,2,3,4-substituted tetrahydroisoquinolines suggests a orthogonal and quite efficient route for psychotropic alkylamine catalysis using Yb(OTf)3 gold nanoparticles as chiral (N-substituted) enamine ligand.... See also the "Stork-Enamine" and "Pictet-Spingler" reactions. 1
  • Etienne Robillard 08:17, 21 January 2013 (EST) In addition, single P-N enantiomers (enamide) can be fused into aromatic heterocycle ring systems in a reaction known as asymmetric hydrogenation. See also Carboxamide, a sulfonamide like carbonic anhydrase inhibitor to block in humans the catalysis of carbonic acid from infectious parasites like P. falciparum, a parasitic worm, thus preventing further cellular respiration to occur. [Related: 1, Malaria, Mefloquine, Carbonic anhydrase] [doi:10.1016/S221-1691(11)60034-8]
  • Etienne Robillard 11:07, 22 January 2013 (EST) Hence, did neuroscience student James Holmes took anti-malarial drug before opening fire in Sandy Hook theater and commiting mass murder of Afghanistan childrens?
    • Etienne Robillard 11:07, 22 January 2013 (EST) In my understanding, the evidences for microwave-triggered (MW) peptide synthesis may provide to crime-scene investigators (CSI) additional evidences to confirm the role of Yb(OTf)3 as an important factor (organocatalyst) in gold-mediated nanoparticles drug delivery, thus a poorly-documented portrait of synthetic biology may emerge in the understanding of common denominators corroborated from theses cases of recent gun shooting into civilian, gun-free zones (schools, theaters, malls, etc).
  • Etienne Robillard 08:36, 23 January 2013 (EST) How many watts of output can generate a single wireless device (ie Iphone) and is this energy input sufficient to catalyze Yb(OTf)3-mediated substrate (a Michael acceptor) in a controlled manner, assuming MW-triggered peptide synthesis has faster reactions time than SPPS to deliver anti-malarial drugs?

See also

Dedication

This page is dedicated to victims of Sandy Hook mass murder which occured on December 14 2012. May our creator give recomfort to the victims of theses uncivilised murdering acts and theses tragedies never be forgotten to identify and resolve the problems in our own life which leaded to such horror scenes. -Etienne Robillard 09:50, 20 December 2012 (EST)

References

  • Reference 1
  • Reference 2
  • 4-(trans)-N-substituted arylcyclohexylamines derived compounds : US7977370, US5622916, US5032616, US4073942, US4113777,US4312861, US3536713, US3336308, US6071966, US5270340, US4595759
  • Substituted cyclohexylaminopyrimidines derivatives: US5723450, US6197729, US6683027

Bibliography

  1. Rueping M and Nachtsheim BJ. . pmid:20485588. PubMed HubMed [Rueping-Boris-J-Nachtsheim-Beilstein-J-Org-Chem-2010]

Glossary

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