User:Etienne Robillard/Notebook/Benzylamine

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== Introduction to phenylmethylamine and physiological relevance in chronic cognitive disfunctions ==
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Surtout vas pas à lecole
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"That men do not learn very much from the lessons of history is the most
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Vas pas essayer d'apprendre de toi-même
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important of all the lessons that history has to teach."  - Aldous Huxley, English novelist, 1959
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=== Use and biological relevance of 2-phenyl-N-methylamine heterocycles ===
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Pose surtout pas de question
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"Now let us consider another kind of drug – still undiscovered, but probably just around the corner – a drug capable of making people feel happy in situations where they would normally feel miserable. Such a drug would be a blessing, but a blessing fraught with grave political dangers. By making harmless chemical euphoria freely available, a dictator could reconcile an entire population to a state of affairs to which self-respecting human beings ought not to be reconciled. Despots have always found it necessary to supplement force by political or religious propaganda. In this sense the pen is mightier than the sword. But mightier than either the pen or the sword is the pill. In mental hospitals it has been found that chemical restraint is far more effective than strait jackets or psychiatry. The dictatorships of tomorrow will deprive men of their freedom, but will give them in exchange a happiness none the less real, as a subjective experience, for being chemically induced. The pursuit of happiness is one of the traditional rights of man; unfortunately, the achievement of happiness may turn out to be incompatible with another of man's rights – liberty." [1]
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Chu prêt à te donner 80000 piastres par année pour pas que tu y ailles ok?
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Primary learning objectives:
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-- Jean et Pauline
 +
 
 +
=== Introduction ===
 +
 
 +
Pour sortir de l'état policier, sauvons les hommes capablent d'agir en homme et défendrent les nôtres et notre pays que deviendrait le Québec en interdisant formellement l'expérimentation sur des civils et rendant publique les données de recherche obtenues sur les effets de ces aérosols sur les humains, données non-officialisés par des scientifiques tenues au silence sous menace de coupures budgetaire ou même d'injection au palipéridone, comme si le silence peut remplacer les vingt-dernières années de recherche en développement d'agents synthétique tel que le isocyanure et les nanoparticules de troisième générations, c'est-à-dire des composés métallo-chimique pour activer à distance des molécules de synthèses transformés en acide aminés, et des proteines synthétiques, utilisant le cyanide pour synthétiser des circuits neurologiques, réfléchissant à votre place, et posant des gestes que votre conscience vous interdirait, dans le cas que vous avez une conscience, bien sûr, et que celle-ci serve à protéger notre bien-être, et non de le détruire invariablement par votre incapacité à penser par vous-même, par mépris ou par crainte des conséquences sans doute, et de perdre le peu dont il reste de ce bien-être menacé par ces actes de terrorismes dirigés contre des civils, les rendant saouls, ou même dangereux, ne pouvant faire foi de l'intelligence qu'ils reçu pour s'en servir, il leur fût appris à recourir à l'aggressivité et la violence pour exister dans ce monde et cette société corrompu et victime de manipulation politique.
 +
 
 +
=== Ugi route to Wilmslow: Remote control of live human bodies, and method for driving them to suicidal habits like lemmings using Ugi convertible isonitriles synthesis and benzylamine-induced locomotor hyperactivity  ===
 +
 
 +
Chuck: A prelude to the industrialisation of the human genome ? For whom and what purposes, mind you ?
 +
 
 +
Oracle: I guess a jolie femme might want to tell you this.
 +
 
 +
Chuck: Are you drunk? And why french now? I thought you were refusing the talk the language they used to refute your points so incessantly.
 +
 
 +
Oracle: Mind you? Cute ladies are everywhere, just like in a lab. They move in and out everywheres and put a wonderful smell around you.
 +
 
 +
Chuck: That must be love without a doubt.
 +
 
 +
Oracle: Without a doubt it must be it.
 +
 
 +
Chuck: I don't want you to get in troubles just for pretending humans are fully lemmingable machines.
 +
 
 +
Oracle: whats wrong with science reality ? I though you loved the concept of the lemmings abstraction :)
 +
 
 +
Chuck: Its abstrachachachatization.
 +
 
 +
Chuck: It looks better with the chachacha thing.
 +
 
 +
 
 +
"That men do not learn very much from the lessons of history is the most important of all the lessons that history has to teach."  - Aldous Huxley, English novelist, 1959
 +
 
 +
"Now let us consider another kind of drug – still undiscovered, but probably just around the corner – a drug capable of making people feel happy in situations where they would normally feel miserable. Such a drug would be a blessing, but a blessing fraught with grave political dangers. By making harmless chemical euphoria freely available, a dictator could reconcile an entire population to a state of affairs to which self-respecting human beings ought not to be reconciled. Despots have always found it necessary to supplement force by political or religious propaganda. In this sense the pen is mightier than the sword. But mightier than either the pen or the sword is the pill. In mental hospitals it has been found that chemical restraint is far more effective than strait jackets or psychiatry. The dictatorships of tomorrow will deprive men of their freedom, but will give them in exchange a happiness none the less real, as a subjective experience, for being chemically induced. The pursuit of happiness is one of the traditional rights of man; unfortunately, the achievement of happiness may turn out to be incompatible with another of man's rights – liberty." - Aldous Huxley
 +
 
 +
Learning modules:
 +
* [[User:Etienne_Robillard/Notebook/30C6HSL|30C6HSL]]: Adventures in the land of psychochemical agents. (Start here when ready to make responsible usage of scientific knowledge! :)
 +
* [[User:Etienne_Robillard/Notebook/Arylcyclohexylamines|Arylcyclohexylamines]]: Conformational chair formation of 4-trans-7-aminoalkylamino-2,1,3-benzoxadiazoles via the Pictet Spengler route to Wilmslow.
 +
 
 +
Learning topics:
* Study and analyze the historical relevance of phenolic compounds and their related psychochemical media (ie: purines) used for research in synthetic biology and how theses compounds may impact or influence the development of biochemical warfare agents used for bioterrorism purposes. Secondly, identify the synthetic origins of the psychochemical compound and a general method for the human body to safely neutralize the phenoxy-alkylamine compound (drug) using competitive enzyme kinetics inhibitors.  
* Study and analyze the historical relevance of phenolic compounds and their related psychochemical media (ie: purines) used for research in synthetic biology and how theses compounds may impact or influence the development of biochemical warfare agents used for bioterrorism purposes. Secondly, identify the synthetic origins of the psychochemical compound and a general method for the human body to safely neutralize the phenoxy-alkylamine compound (drug) using competitive enzyme kinetics inhibitors.  
* Verify the importance of Ketamine-induced disassociative behavior in phenylmethylamine derived drug delivery via asymmetric PS catalysed microwaves [2]
* Verify the importance of Ketamine-induced disassociative behavior in phenylmethylamine derived drug delivery via asymmetric PS catalysed microwaves [2]
-
* Notice the 2.45 GHz factor in Fmoc-based (MW) polymer based drug delivery in DNA depurination.  
+
* Notice the 2.45 GHz factor in Fmoc-based (MW) polymer based drug delivery in DNA depurination.
 +
*<font color="purple" style="background-color:#ddd">"It stoichiometrically catalyzed the hydrolysis of N-benzylformamide (an N-substituted formamide) to benzylamine and formate [7]."</font> http://www.wikigenes.org/e/chem/e/7504.html
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* 3.5.9.1:  N-benzylformamide + H2O = formate + benzylamine (ie: increase in NADH+ catalysis?) http://www.kegg.jp/dbget-bin/www_bget?ec:3.5.1.91
===  Selective NMDA receptor antagonist (N-substituted benzoxazole heterocyclics) ===  
===  Selective NMDA receptor antagonist (N-substituted benzoxazole heterocyclics) ===  
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# Aldous Huxley, Drugs That Shape Men's Minds, 1958, http://csp.org/practices/entheogens/docs/huxley-drugs.html
# Aldous Huxley, Drugs That Shape Men's Minds, 1958, http://csp.org/practices/entheogens/docs/huxley-drugs.html
# http://www.wikigenes.org/e/chem/e/7504.html
# http://www.wikigenes.org/e/chem/e/7504.html
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## Notable (interesting) excerpts about clinical relevance of benzylamine-linked substrates:
 +
### ''Among monoamines tested, three compounds namely phenylethylamine, tyramine and benzylamine were shown to be good substrates for superoxide-generating reactions by the Cu-bound helical peptide.Conclusions: Possible roles for these reactions in development of prion disease were suggested [14].''
 +
### <font color=purple>''We show that 4 catalyzes the aerobic oxidative deamination of <b>benzylamine</b>, though turnover eventually ceases on account of oxidation of the <u>dihydrobenzoxazole tautomer</u> of the "product Schiff base" to form a benzoxazole, a reaction that may be physiologically relevant [16].''</font>
 +
### ''Relation of blood serotonin and benzylamine oxidase to clinical symptoms and prognosis in Parkinson's disease [12].''
 +
### ''In the presence of Ba2+ (1 mM) or in Ca(2+)-free perfusions, the benzylamine-induced net K+ efflux was diminished by 60-70% or about 30%, respectively [33].''
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### ''In this work, we therefore investigated whether benzylamine on its own was able to induce both in vivo and in vitro insulin-like responses in animal models other than rat [36].''
=== See also ===
=== See also ===
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* [[Phenylalinine]]
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* [[Phenylalanine]]
* [[THF]]
* [[THF]]
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* [[User:Etienne_Robillard/Notebook/Trichloroisocyanuric_acid|Tricholoroisocyanuric acid]] -> acylating agent
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* http://www.sciencedirect.com/science/article/pii/S0021951709001079
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* Discussion on convertible (cyclohexanoyl) isocyanide synthesis: http://www.sciencemadness.org/talk/viewthread.php?tid=12774
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* Cycloalkane chemistry (ie "branched" alcohol) overview (review data on chair conformations?): http://www.chemeurope.com/en/encyclopedia/Cycloalkane.html#Ring_strain
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* [http://www.grossmont.net/tomolmstead/Chem232_2007/Reactions%20of%20Carbonyl%20Compounds.htm#4.__Claisen_Ester_Condensation Claisen Ester Condensation]
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----
----
[[Category:Psychochemical]]
[[Category:Psychochemical]]
[[Category:Phenoxyalkylamine]]
[[Category:Phenoxyalkylamine]]

Revision as of 20:00, 2 July 2013

Surtout vas pas à lecole

Vas pas essayer d'apprendre de toi-même

Pose surtout pas de question

Chu prêt à te donner 80000 piastres par année pour pas que tu y ailles ok?

-- Jean et Pauline

Contents

Introduction

Pour sortir de l'état policier, sauvons les hommes capablent d'agir en homme et défendrent les nôtres et notre pays que deviendrait le Québec en interdisant formellement l'expérimentation sur des civils et rendant publique les données de recherche obtenues sur les effets de ces aérosols sur les humains, données non-officialisés par des scientifiques tenues au silence sous menace de coupures budgetaire ou même d'injection au palipéridone, comme si le silence peut remplacer les vingt-dernières années de recherche en développement d'agents synthétique tel que le isocyanure et les nanoparticules de troisième générations, c'est-à-dire des composés métallo-chimique pour activer à distance des molécules de synthèses transformés en acide aminés, et des proteines synthétiques, utilisant le cyanide pour synthétiser des circuits neurologiques, réfléchissant à votre place, et posant des gestes que votre conscience vous interdirait, dans le cas que vous avez une conscience, bien sûr, et que celle-ci serve à protéger notre bien-être, et non de le détruire invariablement par votre incapacité à penser par vous-même, par mépris ou par crainte des conséquences sans doute, et de perdre le peu dont il reste de ce bien-être menacé par ces actes de terrorismes dirigés contre des civils, les rendant saouls, ou même dangereux, ne pouvant faire foi de l'intelligence qu'ils reçu pour s'en servir, il leur fût appris à recourir à l'aggressivité et la violence pour exister dans ce monde et cette société corrompu et victime de manipulation politique.

Ugi route to Wilmslow: Remote control of live human bodies, and method for driving them to suicidal habits like lemmings using Ugi convertible isonitriles synthesis and benzylamine-induced locomotor hyperactivity

Chuck: A prelude to the industrialisation of the human genome ? For whom and what purposes, mind you ?

Oracle: I guess a jolie femme might want to tell you this.

Chuck: Are you drunk? And why french now? I thought you were refusing the talk the language they used to refute your points so incessantly.

Oracle: Mind you? Cute ladies are everywhere, just like in a lab. They move in and out everywheres and put a wonderful smell around you.

Chuck: That must be love without a doubt.

Oracle: Without a doubt it must be it.

Chuck: I don't want you to get in troubles just for pretending humans are fully lemmingable machines.

Oracle: whats wrong with science reality ? I though you loved the concept of the lemmings abstraction :)

Chuck: Its abstrachachachatization.

Chuck: It looks better with the chachacha thing.


"That men do not learn very much from the lessons of history is the most important of all the lessons that history has to teach." - Aldous Huxley, English novelist, 1959

"Now let us consider another kind of drug – still undiscovered, but probably just around the corner – a drug capable of making people feel happy in situations where they would normally feel miserable. Such a drug would be a blessing, but a blessing fraught with grave political dangers. By making harmless chemical euphoria freely available, a dictator could reconcile an entire population to a state of affairs to which self-respecting human beings ought not to be reconciled. Despots have always found it necessary to supplement force by political or religious propaganda. In this sense the pen is mightier than the sword. But mightier than either the pen or the sword is the pill. In mental hospitals it has been found that chemical restraint is far more effective than strait jackets or psychiatry. The dictatorships of tomorrow will deprive men of their freedom, but will give them in exchange a happiness none the less real, as a subjective experience, for being chemically induced. The pursuit of happiness is one of the traditional rights of man; unfortunately, the achievement of happiness may turn out to be incompatible with another of man's rights – liberty." - Aldous Huxley

Learning modules:

  • 30C6HSL: Adventures in the land of psychochemical agents. (Start here when ready to make responsible usage of scientific knowledge! :)
  • Arylcyclohexylamines: Conformational chair formation of 4-trans-7-aminoalkylamino-2,1,3-benzoxadiazoles via the Pictet Spengler route to Wilmslow.

Learning topics:

  • Study and analyze the historical relevance of phenolic compounds and their related psychochemical media (ie: purines) used for research in synthetic biology and how theses compounds may impact or influence the development of biochemical warfare agents used for bioterrorism purposes. Secondly, identify the synthetic origins of the psychochemical compound and a general method for the human body to safely neutralize the phenoxy-alkylamine compound (drug) using competitive enzyme kinetics inhibitors.
  • Verify the importance of Ketamine-induced disassociative behavior in phenylmethylamine derived drug delivery via asymmetric PS catalysed microwaves [2]
  • Notice the 2.45 GHz factor in Fmoc-based (MW) polymer based drug delivery in DNA depurination.
  • "It stoichiometrically catalyzed the hydrolysis of N-benzylformamide (an N-substituted formamide) to benzylamine and formate [7]." http://www.wikigenes.org/e/chem/e/7504.html
  • 3.5.9.1: N-benzylformamide + H2O = formate + benzylamine (ie: increase in NADH+ catalysis?) http://www.kegg.jp/dbget-bin/www_bget?ec:3.5.1.91

Selective NMDA receptor antagonist (N-substituted benzoxazole heterocyclics)

Notes/Todo:

  • corroborate/regroup your results/evidences and demonstrate the inherent functions and purposes of the rogue psychochemical aerosols spraying in Quebec as a potential attempt to induce psychotic-like cognitive pharmacotherapy on unconsentive, disinformed, and unaware civilian populations - in a scientifically acceptable way!
  • Also recheck/verify the corresponding evidences linking asymmetric smart pills medicamentation to unidentified psychochemical media under 2.45 Ghz based microwave (wireless) reactors.
  • Construct a formal hypothesis to further corroborate and verify the scientific evidences of chronic, long-term, exposures of human populations (Quebec, 2001-2013) exposed without their consent and knowledge to psychotropic alkylamines (ie: atypical pharmacological medicamentation)
  • Report the evidences in a scientifically valid way to measure the implications of state-sponsored bioterrorism with psychochemical media/compounds on civilian populations... (See also phenylalinine)

References

  1. Aldous Huxley, Drugs That Shape Men's Minds, 1958, http://csp.org/practices/entheogens/docs/huxley-drugs.html
  2. http://www.wikigenes.org/e/chem/e/7504.html
    1. Notable (interesting) excerpts about clinical relevance of benzylamine-linked substrates:
      1. Among monoamines tested, three compounds namely phenylethylamine, tyramine and benzylamine were shown to be good substrates for superoxide-generating reactions by the Cu-bound helical peptide.Conclusions: Possible roles for these reactions in development of prion disease were suggested [14].
      2. We show that 4 catalyzes the aerobic oxidative deamination of benzylamine, though turnover eventually ceases on account of oxidation of the dihydrobenzoxazole tautomer of the "product Schiff base" to form a benzoxazole, a reaction that may be physiologically relevant [16].
      3. Relation of blood serotonin and benzylamine oxidase to clinical symptoms and prognosis in Parkinson's disease [12].
      4. In the presence of Ba2+ (1 mM) or in Ca(2+)-free perfusions, the benzylamine-induced net K+ efflux was diminished by 60-70% or about 30%, respectively [33].
      5. In this work, we therefore investigated whether benzylamine on its own was able to induce both in vivo and in vitro insulin-like responses in animal models other than rat [36].

See also


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