User:Tkadm30/Notebook/Brainstorming: Difference between revisions

From OpenWetWare
Jump to navigationJump to search
No edit summary
No edit summary
Line 2: Line 2:
* Sites of interests: p38 (MEK), EGFR (Fyn), c-Src homolog domain (brain/hippocampus/amygdala), Ras/Raf/MEK pathway (Bcl-2), NMDAR, NRG1
* Sites of interests: p38 (MEK), EGFR (Fyn), c-Src homolog domain (brain/hippocampus/amygdala), Ras/Raf/MEK pathway (Bcl-2), NMDAR, NRG1
* <font color=red>Cannabinoid agonists and the cholinergic system: Selective affinity for the mAChR receptor may indicates endogenous endocannabinoids as potential agents for neuroprotection agaisn't [http://www.sciencedaily.com/releases/2012/12/121202113712.htm organophosphate-derived] nerve gas precursors and Alzheimer disease.</font> (EC 3.1.1.8)  
* <font color=red>Cannabinoid agonists and the cholinergic system: Selective affinity for the mAChR receptor may indicates endogenous endocannabinoids as potential agents for neuroprotection agaisn't [http://www.sciencedaily.com/releases/2012/12/121202113712.htm organophosphate-derived] nerve gas precursors and Alzheimer disease.</font> (EC 3.1.1.8)  
* Key roles for nanoparticles based chemical inducers and repressors are multiples and under intense research including but not limited to chemotherapy and bioinformatics.
* Key roles for nanoparticles based chemical inducers and repressors are multiples and under intense research including but not limited to chemotherapy, bioinformatics, and synthetic biology.
* Endocannabinoid transport
* Endocannabinoid transport
** retrograde 2-AG signaling may promote glutamatergic LTP. [https://www.ncbi.nlm.nih.gov/pubmed/23307660 PMID]
** retrograde 2-AG signaling may promote glutamatergic LTP. [https://www.ncbi.nlm.nih.gov/pubmed/23307660 PMID]

Revision as of 05:31, 3 October 2015

  • Important secondary messengers: NMDA, Dopamine, Serotonin, GABA, AChr, calmodulin, p38 MAP kinase
  • Sites of interests: p38 (MEK), EGFR (Fyn), c-Src homolog domain (brain/hippocampus/amygdala), Ras/Raf/MEK pathway (Bcl-2), NMDAR, NRG1
  • Cannabinoid agonists and the cholinergic system: Selective affinity for the mAChR receptor may indicates endogenous endocannabinoids as potential agents for neuroprotection agaisn't organophosphate-derived nerve gas precursors and Alzheimer disease. (EC 3.1.1.8)
  • Key roles for nanoparticles based chemical inducers and repressors are multiples and under intense research including but not limited to chemotherapy, bioinformatics, and synthetic biology.
  • Endocannabinoid transport
    • retrograde 2-AG signaling may promote glutamatergic LTP. PMID
    • retrograde 2-AG signaling is ATP-dependent PMID
    • non-retrograde TRPV1 activation by endogenous anandamide transporter (neuroprotective)
    • neuron-astrocyte signaling PMID
  • Allosteric modulation of glycine receptors by endocannabinoids
    • THC and anandamide may modulates synaptogenesis in the retina and brain through glycinergic transmission PMID
    • DHA facilitate NMDA receptor activation in the presence of glycine PMID
    • THC and anandamide enhance NMDA-dependent LTP through glycine receptor activation