User:Tkadm30/Notebook/Brainstorming: Difference between revisions

Revision as of 06:00, 10 July 2015

Important secondary messengers: NMDA, Dopamine, Serotonin, GABA, AChr, calmodulin, p38 MAP kinase
Sites of interests: p38 (MEK), EGFR (Fyn), c-Src homolog domain (brain/hippocampus/amygdala), Ras/Raf/MEK pathway (Bcl-2), NMDAR, NRG1
Cannabinoid agonists and the cholinergic system: Selective affinity for the mAChR receptor may indicates endogenous endocannabinoids as potential agents for neuroprotection agaisn't organophosphate-derived nerve gas precursors and Alzheimer disease. (EC 3.1.1.8)
Key roles for nanoparticles based chemical inducers and repressors are multiples and under intense research including but not limited to chemotherapy and bioinformatics.
Endocannabinoid transport
- retrograde 2-AG signaling may promote glutamatergic LTP. PMID
- retrograde 2-AG signaling is ATP-dependent PMID
- non-retrograde TRPV1 activation by endogenous anandamide transporter (neuroprotective)
- neuron-astrocyte signaling

@@ Line 6: / Line 6: @@
 ** retrograde 2-AG signaling may promote glutamatergic LTP. [https://www.ncbi.nlm.nih.gov/pubmed/23307660 PMID]
 ** retrograde 2-AG signaling is ATP-dependent [https://www.ncbi.nlm.nih.gov/pubmed/23018918 PMID]
+** non-retrograde TRPV1 activation by endogenous anandamide transporter (neuroprotective)
+** neuron-astrocyte signaling