User:Tkadm30/Notebook/Brainstorming

Nanoparticles

• Key roles for nanoparticles based drug delivery systems are multiples and under intense research including but not limited to chemotherapy, bioinformatics, and synthetic biology.
  • Keywords: molecular delivery, directed molecular evolution
• Nanoparticles can alter behavior and learning capability by modulation of monoamine neurotransmitters. [1]

Nanoparticles-mediated ultrasonic neuromodulation of brain activity

• http://www.ncbi.nlm.nih.gov/pubmed/26168074
  • Keywords: barium titanate
• How can ultrasonic neuromodulation remotely control brain activity?

Retrograde endocannabinoid signaling

• Allosteric modulation of glycine receptors by endocannabinoids
  • THC and anandamide may modulates synaptogenesis in the retina and brain through glycinergic transmission [2]
  • DHA facilitate NMDA receptor activation in the presence of glycine [3]
  • THC and anandamide enhance NMDA-dependent LTP through glycine receptor activation

Cannabinoid-induced cholinergic neurotransmission

• Hypothalamic POMC neurons promote CB1-induced feeding [4]
• Caffeine potentiate striatal neurotransmission through presynaptic CB1 receptor activation. [5]
• Monoamine oxidase inhibition affects cannabinoid-induced synaptogenesis. [6]

Sluggish schizophrenia; political manipulations of psychiatry

• Schizophrenia is a man-made disease; Its goal is to control consciousness based on subjectives views of psychology.
  • Schizophrenia is a scam to alter consciousness with antipsychotics; It is a deliberate attempt to alienate creativity of the mind with synthetic chemicals and destroy consciousness.
• "Psychiatry as a means of intimidation": The bliss of ignorance is deeper in the region of tyranny.
  • http://schizophreniabulletin.oxfordjournals.org/content/36/1/33.full
  • Psychiatry is psychological oppression.

Theories of consciousness

• Consciousness can be defined as a bidirectional communication between a living organism and himself.
• Consciousness and reality: A neuropsychological perspective
• Ubiquity of consciousness; The brain is not the source of consciousness: http://www.tandfonline.com/doi/full/10.1080/19420889.2015.1085138
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245704/
• Intrinsic awareness (IA); A machine has no internal purpose within. http://arxiv.org/abs/1101.2422

References

1. https://www.jstage.jst.go.jp/article/jts/36/3/36_3_267/_article

   Nasal instillation of nanoparticle-rich diesel exhaust particles slightly affects emotional behavior and learning capability in rats

2. Hejazi N, Zhou C, Oz M, Sun H, Ye JH, and Zhang L. Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors. Mol Pharmacol. 2006 Mar;69(3):991-7. DOI:10.1124/mol.105.019174 |

   Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors.

3. Nishikawa M, Kimura S, and Akaike N. Facilitatory effect of docosahexaenoic acid on N-methyl-D-aspartate response in pyramidal neurones of rat cerebral cortex. J Physiol. 1994 Feb 15;475(1):83-93. DOI:10.1113/jphysiol.1994.sp020051 |

   Facilitatory effect of docosahexaenoic acid on N-methyl-D-aspartate response in pyramidal neurones of rat cerebral cortex.

4. Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao XB, Diano S, and Horvath TL. Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature. 2015 Mar 5;519(7541):45-50. DOI:10.1038/nature14260 |

   Hypothalamic POMC neurons promote cannabinoid-induced feeding.

5. Rossi S, De Chiara V, Musella A, Mataluni G, Sacchetti L, Siracusano A, Bernardi G, Usiello A, and Centonze D. Caffeine drinking potentiates cannabinoid transmission in the striatum: interaction with stress effects. Neuropharmacology. 2009 Mar;56(3):590-7. DOI:10.1016/j.neuropharm.2008.10.013 |

   Caffeine drinking potentiates cannabinoid transmission in the striatum: interaction with stress effects.

6. Singh C, Bortolato M, Bali N, Godar SC, Scott AL, Chen K, Thompson RF, and Shih JC. Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12816-21. DOI:10.1073/pnas.1308037110 |

   Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice.