User:Tkadm30/Notebook/Brainstorming

Genotoxicity of aluminium nanoparticles

• Combustion-derived nanoparticles (coal fly ash) are genotoxic and may contain silicon dioxide, titanium dioxide, aluminium oxide, barium oxide, arsenic and dimethyl sulfate. [1]
• All CDNPs are genotoxic and cause inflammation via oxidative stress. [2]
• Fine particulate matter induce chronic COPD pathogenesis.[3]
• Is geoengineering destroying life?
• What are the consequences of being sprayed with barium and aluminium?
• Are drug nanoparticles harmful in the same way that pollutants are?

Microglial activation

• Activation of the microglia by aluminium nanoparticles disrupt the cytokine/neurotrophin balance.
• Possible role of microglia-derived BDNF signaling on intracellular Ca2+ elevation?

Synaptic hypercomputation

• Biological utilization of quantum nonlocality: Is synaptic hypercomputation a function of exocytosis?
• Is quantum interference in brain activity possible?

Phase coherence of synaptic hypercomputation

• Retrograde signaling and synaptogenesis regulate phase coherence of synaptic exocytosis?
• What is coherent synaptic transmission?

Retrograde signaling

• Allosteric modulation of glycine receptors by endocannabinoids
  • THC and anandamide may modulates synaptogenesis in the retina and brain through glycinergic transmission [4]
  • DHA facilitate NMDA receptor activation in the presence of glycine [5]
  • THC and anandamide enhance NMDA-dependent LTP through glycine receptor activation

CB1-induced cholinergic neurotransmission

• Hypothalamic POMC neurons promote CB1-induced feeding [6]
• Caffeine potentiate striatal neurotransmission through presynaptic CB1 receptor activation. [7]
• Monoamine oxidase inhibition affects cannabinoid-induced synaptogenesis. [8]

intracellular CB1/BDNF signaling

• CB1 receptor activation induce striatal neuroprotection through a PI3K/Akt/mTORC1/BDNF pathway. [9]

Political manipulations of psychiatry (Sluggish schizophrenia)

• Modern psychiatry is a pseudoscience; Its goal is to alienate consciousness based on pseudoscientific voodoo.
  • Schizophrenia is a scam to subvert consciousness with antipsychotics (AP)
• "Psychiatry as a means of intimidation": http://schizophreniabulletin.oxfordjournals.org/content/36/1/33.full
  • Psychiatry is psychological oppression.

Ubiquity of consciousness

• The brain is not the source of consciousness: http://www.tandfonline.com/doi/full/10.1080/19420889.2015.1085138
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245704/
• Intrinsic awareness (IA); A machine has no internal purpose within. http://arxiv.org/abs/1101.2422

References

1. Lee ML, Later DW, Rollins DK, Eatough DJ, and Hansen LD. Dimethyl and monomethyl sulfate: presence in coal fly ash and airborne particulate matter. Science. 1980 Jan 11;207(4427):186-8. DOI:10.1126/science.7350652 |

   Dimethyl and monomethyl sulfate: presence in coal fly ash and airborne particulate matter.

2. http://particleandfibretoxicology.biomedcentral.com/articles/10.1186/1743-8977-2-10

   Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure.

3. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617054/

   Fine particulate matter in acute exacerbation of COPD.

4. Hejazi N, Zhou C, Oz M, Sun H, Ye JH, and Zhang L. Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors. Mol Pharmacol. 2006 Mar;69(3):991-7. DOI:10.1124/mol.105.019174 |

   Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors.

5. Nishikawa M, Kimura S, and Akaike N. Facilitatory effect of docosahexaenoic acid on N-methyl-D-aspartate response in pyramidal neurones of rat cerebral cortex. J Physiol. 1994 Feb 15;475(1):83-93. DOI:10.1113/jphysiol.1994.sp020051 |

   Facilitatory effect of docosahexaenoic acid on N-methyl-D-aspartate response in pyramidal neurones of rat cerebral cortex.

6. Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao XB, Diano S, and Horvath TL. Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature. 2015 Mar 5;519(7541):45-50. DOI:10.1038/nature14260 |

   Hypothalamic POMC neurons promote cannabinoid-induced feeding.

7. Rossi S, De Chiara V, Musella A, Mataluni G, Sacchetti L, Siracusano A, Bernardi G, Usiello A, and Centonze D. Caffeine drinking potentiates cannabinoid transmission in the striatum: interaction with stress effects. Neuropharmacology. 2009 Mar;56(3):590-7. DOI:10.1016/j.neuropharm.2008.10.013 |

   Caffeine drinking potentiates cannabinoid transmission in the striatum: interaction with stress effects.

8. Singh C, Bortolato M, Bali N, Godar SC, Scott AL, Chen K, Thompson RF, and Shih JC. Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12816-21. DOI:10.1073/pnas.1308037110 |

   Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice.

9. Blázquez C, Chiarlone A, Bellocchio L, Resel E, Pruunsild P, García-Rincón D, Sendtner M, Timmusk T, Lutz B, Galve-Roperh I, and Guzmán M. The CB₁ cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway. Cell Death Differ. 2015 Oct;22(10):1618-29. DOI:10.1038/cdd.2015.11 |

   The CB₁ cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway.

10. https://www.jstage.jst.go.jp/article/jts/36/3/36_3_267/_article

    Nasal instillation of nanoparticle-rich diesel exhaust particles slightly affects emotional behavior and learning capability in rats