User:Tkadm30/Notebook/Brainstorming

Microglial activation

• Activation of the microglia by aluminium oxide disrupt the cytokine/neurotrophin balance.
• Possible role of microglia-derived BDNF signaling on intracellular Ca2+ elevation? [1]

Nanotoxicity of fine particulate matter (PM2.5)

• Fly-ash particulate matter includes:
  • aluminium oxide
  • silicon dioxide
  • titanium dioxide
  • barium oxide
  • iron oxide
  • cadmium
  • arsenic
  • dimethyl sulfate and monomethyl sulfate[2]
• Exposure to coal fly ash is nanotoxic and may cause neuroinflammation via oxidative stress production. [3]
• Coal fly ash is a source of particulate matter.
• Fine particulate matter (PM2.5) exposure may induce chronic COPD pathogenesis.[4]

Phenomenology of consciousness

The brain is not the source of consciousness:

• http://www.tandfonline.com/doi/full/10.1080/19420889.2015.1085138
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245704/

Intrinsic awareness (IA):

• A machine has no internal purpose within...
• http://arxiv.org/abs/1101.2422

Ubiquity of consciousness:

• Do all living cells have photonic protoconsciousness?

Political manipulations of psychiatry

Sluggish schizophrenia

• Behaviors are not diseases.
• Psychiatry as a means of intimidation: http://schizophreniabulletin.oxfordjournals.org/content/36/1/33.full
  • Psychiatry is psychological oppression.

Retrograde signaling

Glycinergic neurotransmission trafficking

Allosteric modulation of glycine receptors by endocannabinoids

• THC and anandamide may modulates synaptogenesis in the retina and brain through glycinergic transmission [5]
• Intracellular DHA delivery facilitate glutamatergic NMDA receptor function in the presence of glycine [6]
• THC and anandamide enhance NMDA-dependent LTP through glycine receptor activation

CB1-induced cholinergic neurotransmission

• Hypothalamic POMC neurons promote CB1-induced feeding [7]
• Adenosine antagonist (caffeine) potentiate corticostriatal neurotransmission (connectivity) through presynaptic CB1 receptor activation. [8]
• Monoamine oxidase inhibition affects cannabinoid-induced synaptogenesis. [9]

Intracellular CB1/BDNF signaling

• CB1 receptor activation may induce corticostriatal neuroprotection through a PI3K/Akt/mTORC1/BDNF pathway. [10]

Pineal gland

• Dopamine receptors in the pineal gland may control melatonin production via anandamide trafficking? [11][12]

Social neuroscience of cannabis smoking

• Why do you smoke marijuana?
• Cannabis for lucid dreaming therapy?
• The social neuroscience of cannabis smoking

Synaptic hypercomputation

Biological utilization of quantum non-locality in microtubules:

• Is synaptic hypercomputation a function of exocytosis?
• Is quantum interference in brain activity possible?

Biophotonic non-locality:

• The non-local nature of biophotonic energy may require ultra-fast optical communication channels in MTs to transduce a presynaptic action potential into a visible waveform!

Phase coherence of synaptic hypercomputation

Retrograde signaling and synaptogenesis:

• What is coherent synaptic transmission?
• What is synaptic latency?

References

1. https://www.ncbi.nlm.nih.gov/pubmed/25171395

   Positive feedback loop of autocrine BDNF from microglia causes prolonged microglia activation.

2. https://www.ncbi.nlm.nih.gov/pubmed/7350652

   Dimethyl and monomethyl sulfate: presence in coal fly ash and airborne particulate matter.

3. http://particleandfibretoxicology.biomedcentral.com/articles/10.1186/1743-8977-2-10

   Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure.

4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617054/

   Fine particulate matter in acute exacerbation of COPD.

5. https://www.ncbi.nlm.nih.gov/pubmed/16332990

   Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors.

6. https://www.ncbi.nlm.nih.gov/pubmed/7514666

   Facilitatory effect of docosahexaenoic acid on N-methyl-D-aspartate response in pyramidal neurones of rat cerebral cortex.

7. https://www.ncbi.nlm.nih.gov/pubmed/25707796

   Hypothalamic POMC neurons promote cannabinoid-induced feeding.

8. https://www.ncbi.nlm.nih.gov/pubmed/19027757

   Caffeine drinking potentiates cannabinoid transmission in the striatum: interaction with stress effects.

9. https://www.ncbi.nlm.nih.gov/pubmed/23858446

   Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice.

10. https://www.ncbi.nlm.nih.gov/pubmed/25698444

    The CB₁ cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway.

11. https://www.ncbi.nlm.nih.gov/pubmed/18554250

    The rat pineal gland comprises an endocannabinoid system.

12. https://www.ncbi.nlm.nih.gov/pubmed/26061461

    Rhythmic control of endocannabinoids in the rat pineal gland.

13. https://www.jstage.jst.go.jp/article/jts/36/3/36_3_267/_article

    Nasal instillation of nanoparticle-rich diesel exhaust particles slightly affects emotional behavior and learning capability in rats

14. http://pubs.rsc.org/en/content/articlelanding/2017/tx/c6tx00314a

    Synergistic effects of particulate matter (PM2.5) and sulfur dioxide (SO2) on neurodegeneration via the microRNA-mediated regulation of tau phosphorylation.

15. http://jaapl.org/content/35/4/469

    Amnesia and Crime.

16. http://journal.frontiersin.org/article/10.3389/fphar.2016.00355/full

    Splendor in the Grass? A Pilot Study Assessing the Impact of Medical Marijuana on Executive Function

17. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098150/

    Possible existence of optical communication channels in the brain

18. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653148/

    Endocannabinoid signaling mediates oxytocin-driven social reward

19. https://www.ncbi.nlm.nih.gov/pubmed/11826965

    Antihypertensive effects of acetic acid and vinegar on spontaneously hypertensive rats.

20. https://www.ncbi.nlm.nih.gov/pubmed/27264948

    Antipsychotic Induced Dopamine Supersensitivity Psychosis: A Comprehensive Review.

21. https://www.ncbi.nlm.nih.gov/pubmed/26419755

    Vitamin D deficiency and essential hypertension.

22. http://www.sciencedirect.com/science/article/pii/S2251729413000050

    Vitamin D as an effective treatment approach for drug abuse and addiction.

23. https://www.ncbi.nlm.nih.gov/pubmed/24739187

    The in vitro GcMAF effects on endocannabinoid system transcriptionomics, receptor formation, and cell activity of autism-derived macrophages.

24. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266250/

    Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance.

25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783408/

    Psychosis and the Control of Lucid Dreaming.

26. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604174/

    Cannabis in the Treatment of Dystonia, Dyskinesias, and Tics.

27. https://www.ncbi.nlm.nih.gov/pubmed/17439547

    Melatonin as a potential antihypertensive treatment.

28. https://www.ncbi.nlm.nih.gov/pubmed/22527998

    Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects.

29. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955008/

    Multiple Mechanistically Distinct Modes of Endocannabinoid Mobilization at Central Amygdala Glutamatergic Synapses.

See also

• Is geoengineering destroying life?
• What are the consequences of being sprayed with barium and aluminium?
• Are drug nanoparticles harmful in the same way that pollutants are?
• Effects of geoengineering on the limbic system
• What is the role of radiative forcing in cloud physics?
• Hyperdreaming