User:Etienne Robillard/Notebook/NMDA dependent cell adhesion

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=== Notes ===  
=== Notes ===  
-
* A integrin beta3 mutant polypeptide lacking the PTBP1 gene ?
+
* <s>A integrin beta3 mutant polypeptide lacking the PTBP1 gene ?</s>
 +
* A pyrimidine-rich associated polypeptide complex is best known as a "protein".
 +
* A e.coli K12 derived auxotrophic restriction enzyme system may be the key <font color=red>red</font> <font color=purple>heering</font> in understanding protein over-expression factors in the transcription of mRNA.
 +
* '''Dude where's my calcium?''': Zinc/Leucine/Glycine/Serine  (Rho, GNAT, etc) -> KEY Calcium/Magnesium (Ca2+/Mg2+) mediated cell adhesion amino acids; phosphatase-like (transferase) family members...
 +
* Neural (Voltage-gated) ligand expression possible side-effect may include novel psychotic behavior, especially if remotely activated with electromagnetic (RF) signals under 2.45 GHz ? -- Check this.
 +
* "horn" directed mutagenesis: too difficult to realize in vivo? -- Check this!
 +
=== Going a bit further... ===
-
   
+
* Explain dna methylation and role of 30C6HSL (exo-genous) promoters in the upregulation of N-Methyl-D-Aspartate receptor and Calcium channel blockers  
 +
* summarly define how a calcium channel blocker 'block' (disrupt) GABA receptor from processing <font color=purple>visual signals</font> properly in the fore-brain (ie: hippocampus) through a signal transduction cascade...
 +
* What is primary difference between a putative and non-putative gene?
=== References ===
=== References ===
-
# http://www.uniprot.org/uniprot/P20592
+
* Proteins and enzymes:
-
# http://www.uniprot.org/uniprot/P26599
+
# cAMP-dependent protein kinase A (C-alpha): http://www.uniprot.org/uniprot/P17612
-
# EC 2.7.11.1 http://brenda-enzymes.org/php/result_flat.php4?ecno=2.7.11.1&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0
+
# cAMP-dependent protein kinase A (C-beta) : http://www.uniprot.org/uniprot/P22694
-
# EC 2.1.1.43 (SETD8) http://www.genome.jp/dbget-bin/www_bget?hsa:387893
+
# Histone-lysine N-methyltransferase (SETD8) http://www.uniprot.org/uniprot/Q9NQR1 [http://omim.org/entry/607240 OMIM]
-
# '''ITGB2''' http://www.genome.jp/dbget-bin/www_bget?hsa:3689
+
# E-cadherin (CDH1) http://www.uniprot.org/uniprot/P12830 [http://omim.org/entry/192090 OMIM]
-
# OMIM (ITGB2): http://omim.org/entry/600065 (note the chromosome location and the annotated phenotype)
+
* By organism:
 +
# H. sapiens (EC 2.7.11.1) (PTEN-Induced Putative Kinase 1) http://www.genome.jp/dbget-bin/www_bget?hsa:65018 [http://brenda-enzymes.org/php/result_flat.php4?ecno=2.7.11.1&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0 BRENDA]
 +
# H. sapiens (EC 2.1.1.43) (SETD8) http://www.genome.jp/dbget-bin/www_bget?hsa:387893
 +
# H. sapiens ('''ITGB2''') http://www.genome.jp/dbget-bin/www_bget?hsa:3689 [http://omim.org/entry/600065 OMIM] (note the chromosome location and the annotated phenotype)
=== Keywords ===
=== Keywords ===
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* c-Src specialized kinase (SH2/SH3 domain, PH domain, etc)
* c-Src specialized kinase (SH2/SH3 domain, PH domain, etc)
* MAPK <-> c-Src domain interactions and cross-talk, ie integrins mediated cross-talking, see: [[User:Etienne_Robillard/Notebook/EGFR|EGFR]]
* MAPK <-> c-Src domain interactions and cross-talk, ie integrins mediated cross-talking, see: [[User:Etienne_Robillard/Notebook/EGFR|EGFR]]
-
 
+
* http://www.alzforum.org/new/detail.asp?id=2070
----
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Revision as of 20:05, 16 April 2013

Mo calcium, mo visual hallucinations

Contents

Abstract

An essay on the role of the Integrin beta-3 protein (ITGB3) in Ca2+-dependent orthogonal riboswitches.

Introduction

In the study of calcium-mediated (Ca2+) neuronal receptors (NMDA and GABA mostly), the relevance of Ca2+-dependent ligands (ie: calmodulin) may hold important factors in the morphogenesis of psychological brain disorders and the pathogenesis of the Alzheimer disease, a important phenotype in the understanding of GPCR-mediated brain mutations. Hence a proper understanding of the polypyrimidine tract binding protein-1 (PTBP1) dependent signaling pathway may reveal new insights in the functions and features of the integrin beta-3 protein as a cell-adhesive (and voltage-gated!) neural substrate for long-term axon and neuronal growth. [1]

Notes

  • A integrin beta3 mutant polypeptide lacking the PTBP1 gene ?
  • A pyrimidine-rich associated polypeptide complex is best known as a "protein".
  • A e.coli K12 derived auxotrophic restriction enzyme system may be the key red heering in understanding protein over-expression factors in the transcription of mRNA.
  • Dude where's my calcium?: Zinc/Leucine/Glycine/Serine (Rho, GNAT, etc) -> KEY Calcium/Magnesium (Ca2+/Mg2+) mediated cell adhesion amino acids; phosphatase-like (transferase) family members...
  • Neural (Voltage-gated) ligand expression possible side-effect may include novel psychotic behavior, especially if remotely activated with electromagnetic (RF) signals under 2.45 GHz ? -- Check this.
  • "horn" directed mutagenesis: too difficult to realize in vivo? -- Check this!

Going a bit further...

  • Explain dna methylation and role of 30C6HSL (exo-genous) promoters in the upregulation of N-Methyl-D-Aspartate receptor and Calcium channel blockers
  • summarly define how a calcium channel blocker 'block' (disrupt) GABA receptor from processing visual signals properly in the fore-brain (ie: hippocampus) through a signal transduction cascade...
  • What is primary difference between a putative and non-putative gene?

References

  • Proteins and enzymes:
  1. cAMP-dependent protein kinase A (C-alpha): http://www.uniprot.org/uniprot/P17612
  2. cAMP-dependent protein kinase A (C-beta) : http://www.uniprot.org/uniprot/P22694
  3. Histone-lysine N-methyltransferase (SETD8) http://www.uniprot.org/uniprot/Q9NQR1 OMIM
  4. E-cadherin (CDH1) http://www.uniprot.org/uniprot/P12830 OMIM
  • By organism:
  1. H. sapiens (EC 2.7.11.1) (PTEN-Induced Putative Kinase 1) http://www.genome.jp/dbget-bin/www_bget?hsa:65018 BRENDA
  2. H. sapiens (EC 2.1.1.43) (SETD8) http://www.genome.jp/dbget-bin/www_bget?hsa:387893
  3. H. sapiens (ITGB2) http://www.genome.jp/dbget-bin/www_bget?hsa:3689 OMIM (note the chromosome location and the annotated phenotype)

Keywords

  • Integrins, pyrimidine, glutamine, NMDA, hippocampus, calmodulin, PTBP1, neuropeptides, b-secretase (BACE)

For next time!

  • Review and complete wiki class page on Integrase.
  • Review Calcium and GABA signaling? (Hint: Wet blanket for Calcium-mediated glutamine excitoxicity!)
  • beta-amyloids APP - In the synthesis of 1,2,3,4-tetrahydroisoquinolines derivatives via asymmetric PS synthesis, how is beta-linked amyloids (note: For the Alzheimer precursor protein type "APP" on uniprot) responding to 2.45 GHz electromagnetic waves (2.450 GHz is a typical radio-frequency (RF) signal used in portable human wireless devices; Iphone4-type device; etc) for horn-directed mutagenesis of neuronal X-linked polypeptides/ligands ? -ER
  • Moreover assuming the psychochemical media require a ultra-sound frequency (ie: 2.450 GHz) to INDUCE mRNA-activated polypeptide alkane isomerisation of the PTBP1 genes, how mentally retarded do you estimate a human-made decision must be (IQ) to allow and implement the forced installation of such biological assault devices without the consent and informed judgement into the homes and residences of civilians ? -ER
    • Important Note: Back in World-war 2, Ziklon-b pellets (Auschwitz) were found to dispense the deadly compound to the prisoneers from the outside of the concentration camps. Based on theses evidences, which experimental protocol may you use to measure and verify the risks and effects of cumulative exposure to 1,2,3,4-tetrahydroisoquinolines derivatives ? -ER
    • Furthermore, based on the evidences correlated to the implementation of such potentially harmful and intrusive technology into unprotected homes (non-ionising EM waves) to human health, do you believe the idea/concept of "smart metering" is an affront to human dignity and thus in direct conflict with the principle of saving lifes  ? -ER
  • Review this paper here about the DNA methylation of neuropeptides with cyanide affects the NMDA receptor.
    • For Acetonitrile based cyanolation reagents, see: Acetonitrile
    • For simple alcohol-based polypeptide cross-linker reagents (dA), see: PVA and Isopropanol

See also...


"Courage is resistance to fear, mastery of fear, not absence of fear." -Mark Twain

"You will never do anything in this world without courage. It is the greatest quality of the mind next to honor." - Aristotle

"Success is not final, failure is not fatal: it is the courage to continue that counts." -Winston Churchill

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