User:Etienne Robillard/Notebook/chim trills notebook

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'''Work-in-progress.'''
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__TOC__
 
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Welcome!
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{{LnNotebookRecentChanges2}}
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This is an experimental (and open to all) notebook dedicated in understanding the so-called "chemtrails" phenomenon from scratch.
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__TOC__
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The project is currently licensed under [http://www.gnu.org/copyleft/fdl.html GNU Free Documentation License Version 1.3].
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== Hypothesis ==
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1. Unilateral/clandestine solar geoengineering activity is a source of air pollution/particulate matter. ('''PM2.5''')
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== License ==
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2. The molecular toxicity of PM2.5 is poorly understood.
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Copyright (C)  2012 Etienne Robillard
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3. The nanotoxicity, neurotoxicity, and genotoxicity of PM2.5 exposure on human health requires further investigations.
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Permission is granted to copy, distribute and/or modify this document
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4. The differential effects of chronic PM2.5 exposure on the neuroimmune system, lung/brain axis, chronic inflammation, and neurodegenerative disorders (Alzheimer, Parkinson) requires additional research. <cite>Gilmour-2004</cite>
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Under the terms of the GNU Free Documentation License, Version 1.3
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or any later version published by the Free Software Foundation;
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with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts.
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A copy of the license is included in the section entitled "GNU Free Documentation License".
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== Contents ==
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5. MAC1/Glutaminase activation is implicated in the microglia-mediated dopaminergic neurotoxicity of PM2.5. <cite>Levesque-2013</cite><cite>Liu-2015</cite>
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=== Introduction ===
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== Differential effects of nanoparticles translocation ==
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=== Cardiovascular system ===
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* Effects of particulate matter (PM2.5) air pollution on cardiovascular diseases. <cite>Brook-2010</cite>
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** Increase in blood pressure (hypertension) <cite>Balasubramanian-2013</cite>
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** The association of annual air pollution exposure with blood pressure among patients with sleep-disordered breathing. <cite>Liu-2016</cite>
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* Dysregulation of miRNA expression levels. <cite>Lu-2015</cite>
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Has synthetic biology replaced modern eugenics ? This wiki suggests an attempt to discuss a
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=== Central nervous system ===
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story about eugenics in modern science or as generally referred to as the "chemtrails" phenomenon.
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* Alzheimer disease <cite>Jung-2015</cite><cite>Levesque-2013</cite>
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* Parkinson disease <cite>Levesque-2013</cite>
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* PM2.5 exposure may cause chronic neuroinflammation and oxidative stress. <cite>Lei-2015</cite><cite>Liu-2015</cite><cite>Riva-2011</cite><cite>Levesque-2011</cite>
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* PM2.5 exposure may induce selective neurotoxicity through glutamatergic signaling and increase NMDA-induced excitotoxicity. <cite>Liu-2015</cite><cite>Morgan-2011</cite>
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* Cyclooxygenase-2, interleukin-1beta, and CD14 signaling upregulation. <cite>Solt-2008</cite>
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* Microglia-mediated dopaminergic neurotoxicity (Reactive microgliosis). <cite>Levesque-2013</cite>
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=== Abstract ===
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=== Endocrine system ===
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* Decrease of serum testosterone levels <cite>Lavicoli-2013</cite>
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* Increase of serum estradiol levels <cite>Lavicoli-2013</cite>
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* Autoimmune disorders <cite>Bernatsky-2016</cite>
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Chemtrails is a recent phenomenon I started to observe around 2009.  
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=== Limbic system ===
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* Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus. <cite>Chao-2017</cite>
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At this time I had very little knowledge about geoengineering or even
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=== Lymphatic system ===
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basic chemistry. I then started to familiarize myself with such phenomenons as they began to occupy further lines of
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* Lipid peroxidation and oxidative DNA/RNA damage. <cite>Ambroz-2016</cite>
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dissipated white lines across unaffected clouds. I then further observed the phenomenon, and noted down the dates
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of such "phenomenons" taking guess on their physical attributes and noticed they were from man-operated aircrafts or some kind of cloaked
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aerial origin. (geoengineering, synthetic biology)
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WW2 (World war 2) was for me a couple of popular American movie scenes including films and other things dealing with Jews being intoxicated with
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poisonous gas in concentration camps. I was not very interested in them and neither in the chemotherapy eugenic "science" which resulted in thousands
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of deaths. (chemotherapy)
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=== Synopsis ===
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=== Respiratory system ===
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* AECOPD <cite>Lei-2015</cite>
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* Lung cancer <cite>Hamra-2014</cite>
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* Into this wiki the reader is invited to extend a experimental semantic framework to organize an human editable reasoning ontology on the current state of "eugenic" events in the Quebec region since September 9/11. (ontology, open data, Quebec).
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== Nanotoxicity of functionalized nanoparticles ==
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* In addition, the ontology should be editable into a chemtrails.owl file and extensible using the XML markup language.
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* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/2014/12/14|Notebook]]
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* Furthermore, the development should be open and documented into this wiki.
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=== Ideas ===
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== Notes ==
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* Condensation aerosols:
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* Extensions to consider for initial release is an accountability module to further record an history of important scientifical misconducts (red cards) related to chemtrails in regard of synthetic biology and valueness (ie: EGFR and b-amyloid precursors aggregation in lipid rafts from tyrosine kinase Fyn gene over-expression).
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** [http://iopscience.iop.org/article/10.1070/RC1965v034n02ABEH001418/pdf Monodisperse aerosols]
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* Coal-Based Jet Fuels:
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** [http://www.energy.psu.edu/sites/default/files/files/JetFuels.pdf Advanced Thermally Stable Jet Fuels]
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** [http://www.energy.psu.edu/sites/default/files/files/coalbased_jetfuel.pdf The Coal-Based Jet Fuel Program]
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** [http://web.stanford.edu/group/pitsch/publication/ColketJet_Fuel_Surrogate_AIAA_2007.pdf Jet Fuel Surrogate Research]
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** [https://dspace.mit.edu/handle/1721.1/9116 Catalytic combustion of methane with nanostructured barium hexaaluminate-based materials]
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* Discussion:
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** [https://www.thenakedscientists.com/forum/index.php?topic=68004 Do coal-based jet fuel (JP-900) emit ultrafine particles?]
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** [https://www.thenakedscientists.com/forum/index.php?topic=67942 Is coal fly ash a synthetic compound?]
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** [https://www.thenakedscientists.com/forum/index.php?topic=68555 Is reactive microgliosis a beneficial or harmful process?]
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** [https://www.thenakedscientists.com/forum/index.php?topic=67302 Should we ban geoengineering?]
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** [https://www.thenakedscientists.com/forum/index.php?topic=68061 What is the Gulf War syndrome?]
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** [https://www.thenakedscientists.com/forum/index.php?topic=68101 What is a jet fuel surrogate?]
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** [https://www.thenakedscientists.com/forum/index.php?topic=69963 Effects of geoengineering on the limbic system]
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* Documentation:
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** [https://en.wikipedia.org/wiki/Dodecane Dodecane (Wikipedia)]
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** [https://en.wikipedia.org/wiki/Ethylbenzene Ethylbenzene (Wikipedia)]
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** [https://en.wikipedia.org/wiki/TLR4 TLR4 (Wikipedia)]
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** [http://www.ncbi.nlm.nih.gov/gene/2744 Glutaminase]
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** [http://www.ncbi.nlm.nih.gov/pubmed/?term=gulf+war+syndrome Gulf War syndrome (PubMed search)]
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** [https://en.wikipedia.org/wiki/Gulf_War_syndrome Gulf War syndrome (Wikipedia)]
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** [https://en.wikipedia.org/wiki/Methylcyclohexane Methylcyclohexane (Wikipedia)]
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=== Credits ===
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== Resources ==
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* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/Introduction|Introduction]]
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* [[User:Etienne_Robillard/Notebook/Brainstorming|Brainstorming]]
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* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/Model|Model]]
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* [[User:Etienne_Robillard/Notebook/Photographic_evidences|Photographic evidences]]
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* [[User:Etienne_Robillard/Notebook/chim_trills_notebook/Research|Research]]
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TODO
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== Keywords ==
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aerosol, bioaerosol, functionalized nanoparticles, aluminium oxide, particulate matter, PM2.5, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium, gold, microglia, MAC1, monodisperse aerosol, condensation,
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drug delivery
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=== History ===
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== Support this project ==
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TODO
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This project is entirely financed by personal donations. To support this project, use the following link
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to donate money via Paypal: https://paypal.me/EtienneRobillard
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=== Subtopics ===
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== References ==
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<biblio>
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#Herndon-2015 http://www.mdpi.com/1660-4601/12/8/9375/htm
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//Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health
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#Herndon-2016 http://nuclearplanet.com/frontiers1.pdf
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//Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification.
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#Gilmour-2004 https://www.ncbi.nlm.nih.gov/pubmed/15061611
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//Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion.
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#Brook-2010 https://www.ncbi.nlm.nih.gov/pubmed/20458016
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//Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association.
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#Jung-2015 https://www.ncbi.nlm.nih.gov/pubmed/25310992
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//Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan.
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#Lei-2015 http://journal.frontiersin.org/article/10.3389/fphys.2015.00294/full
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//Fine particulate matter in acute exacerbation of COPD.
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#Hamra-2014 https://www.ncbi.nlm.nih.gov/pubmed/24911630
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//Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis.
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#Liu-2015 https://www.ncbi.nlm.nih.gov/pubmed/25913161
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//Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation.
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#Riva-2011 https://www.ncbi.nlm.nih.gov/pubmed/21506876
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//Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice.
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#Levesque-2011 https://www.ncbi.nlm.nih.gov/pubmed/21561831
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//Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity.
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#Morgan-2011 https://www.ncbi.nlm.nih.gov/pubmed/21724521
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//Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro.
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#Cheng-2010 http://www.tandfonline.com/doi/abs/10.1080/027868201753306714
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//Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels.
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#Ambroz-2016 https://www.ncbi.nlm.nih.gov/pubmed/27321041
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//Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns.
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#Balasubramanian-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402685/
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//Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats.
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#Lavicoli-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759935/
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//The Effects of Nanomaterials as Endocrine Disruptors.
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#Solt-2008 https://www.ncbi.nlm.nih.gov/pubmed/18349428
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//Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults.
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#Levesque-2013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660420/
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//The Role of MAC1 in Diesel Exhaust Particle-induced Microglial Activation and Loss of Dopaminergic Neuron Function
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#Chao-2017 https://www.ncbi.nlm.nih.gov/pubmed/27539004
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//Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus.
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#Liu-2016 https://www.ncbi.nlm.nih.gov/pubmed/26580727
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//The association of annual air pollution exposure with blood pressure among patients with sleep-disordered breathing.
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#Bernatsky-2016 https://www.ncbi.nlm.nih.gov/pubmed/25988990
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//Fine particulate air pollution, nitrogen dioxide, and systemic autoimmune rheumatic disease in Calgary, Alberta.
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#Lu-2015 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782360/
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//Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals
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</biblio>
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==== Orthogonal and potentially harmful drug delivery evidences involving undisclosed bioaerosol exposure ====
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== License ==
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Start here if you wish to help:
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Copyright (C)  2012-2017 Etienne Robillard
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* [http://openwetware.org/wiki/User:Etienne_Robillard/Notebook/Chemtrails911_notebook/BCTP BCTP]: Unit 1: Bicomponent Triton X-100 Tri-n-butyl phosphate
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Permission is granted to copy, distribute and/or modify this document
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** Unit 1.1: Oil-in-water nanoemulsions as orthogonal drug delivery systems:
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Under the terms of the GNU Free Documentation License, Version 1.3
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*** [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065798/ Food protein-stabilized nanoemulsions as potential delivery systems for poorly water-soluble drugs: preparation, in vitro characterization, and pharmacokinetics in rats.]
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or any later version published by the Free Software Foundation;
 +
with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts.
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A copy of the license is included in the section entitled "GNU Free Documentation License".
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==== Asymmetric and unconventional gene therapy trials on unwary citizens is scientifically irresponsible ====
 
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Genes/protein:
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__NOTOC__
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* [[/EGFR|Epidermal Growth Factor Receptor (Protein)]]: A key membrane for targeted drug delivery, chemotherapy and perhaps tyrosine kinase protein blocking in '''MAJOR GROUPS''' of '''HUMANS populations''' possessing the '''EGF''' gene...
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* [[/CYP3A4|CYP3A4 (Protein-coding gene)]]
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Cancer therapy drugs :
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== See you in space cowboy ==
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* [[/Paclitaxel|Paclitaxel (Drug)]]:  Compare this with doxorubicin; non EGF(R)-specific (?);
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* [[/Docetaxel|Docetaxel (Drug)]]: A generic paclitaxel molecule used for targeted cancer therapy; Can be combined with Doxorubicin for advanced chemotherapy uses.
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** Thus is Docetaxel classifiable as a DNA Topoisomerase II inhibitor drug '''regulating''' cell-dependent mitosis?
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* [[/Doxorubicin|Doxorubicin (Drug)]]: A anti-malaria (?) drug with EGF(R)-specific binding;
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* [[/Imatinib (Drug)]]: A tyrosine kinase inhibitor drug designed by Novartis. Like Doxorubicin, may produces side effects including skin rashes and headaches. In addition, may also inhibit aCh(R) (acetylcholinesterase) and modulate ATP (adenosine tryphosphate) synthase inside the mitochondria membrane, suggesting Imatinib could have a potential role in regulating neurotransmitter regulation (calmodulin, GABA, etc). However it is unknown at this time if a generic version of this drug could deliver ATP mediated energy payload to epithelial cells from EGFR over-expressed phospholipid (ie: cholesterol). A suggested hypothesis is thus to assert the drug delivery factors of aCh derived receptors associated specifically to EGFR binding site in Alzheimer disease and related ATP based ligands. [Keywords: Imatinib, Alzheimer, ATP, Brain, aChr, calmodulin, EGFR, breast cancer, GABA, Glutamate, Glycine, Tyrosine, Adenosine, NMDA, Serotonin, [http://www.sciencedaily.com/releases/2007/12/071203190607.htm Liposome]]
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See also:
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* [[http://www.chemocare.com/whatis/types_of_chemotherapy.asp Types of Chemotherapy]]
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* [[http://en.wikipedia.org/wiki/Topoisomerase Topoisomerase]] (wikipedia)
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==== Case-studies  ====
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<blockquote>
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"I am free, no matter what rules surround me. If I find them tolerable, I tolerate them; if I find them too obnoxious, I break them.
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I am free because I know that I alone am morally responsible for everything I do." -Robert A. Heinlein
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</blockquote>
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H1N1 flu stuff, by year and relevance of publication. (Unit 3)
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<blockquote>
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"The essence of the independent mind lies not in what it thinks, but in how it thinks."
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― Christopher Hitchens
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</blockquote>
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* [http://www.ncbi.nlm.nih.gov/pubmed/20962084 Modifications in the polymerase genes of a swine-like triple-reassortant influenza virus to generate live attenuated vaccines against 2009 pandemic H1N1 viruses.]
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<blockquote>"Now let us consider another kind of drug – still undiscovered, but probably just around the corner – a drug capable of making people feel happy in situations where they would normally feel miserable. Such a drug would be a blessing, but a blessing fraught with grave political dangers. By making harmless chemical euphoria freely available, a dictator could reconcile an entire population to a state of affairs to which self-respecting human beings ought not to be reconciled. Despots have always found it necessary to supplement force by political or religious propaganda. In this sense the pen is mightier than the sword. But mightier than either the pen or the sword is the pill. In mental hospitals it has been found that chemical restraint is far more effective than strait jackets or psychiatry. The dictatorships of tomorrow will deprive men of their freedom, but will give them in exchange a happiness none the less real, as a subjective experience, for being chemically induced. The pursuit of happiness is one of the traditional rights of man; unfortunately, the achievement of happiness may turn out to be incompatible with another of man's rights – liberty." - Aldous Huxley
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* [http://www.ncbi.nlm.nih.gov/pubmed/20965669 Potential role of viral surface glycoproteins in the replication of H3N2 triple reassortant influenza A viruses in swine and turkeys.]
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</blockquote>
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* [http://www.ncbi.nlm.nih.gov/pubmed/22090121 Highly pathogenic avian influenza virus subtype H5N1 escaping neutralization: more than HA variation.]
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* Recombinant ''B. anthracis'' (endo)spores serving as potential biological agent to deter anthrax and influenza microbes in murrine and swine, or the emergence of nanovaccines in '''orthogonal drug delivery systems''', with potential immunogenic features, like calmodulin (CaM) protein expression, and site-specific antigenic-like response (mutagenesis):
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<blockquote>"Under our noses, over our heads, hidden in plain [https://www.reddit.com/r/chemtrails/comments/609s8u/experimental_evidences_linking_clandestine/ sight]..." - Anonymous</blockquote>
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** http://anthraxvaccine.org (currently out-of-service! Last updated: 2012/03/30. Why is the downtime not resolved??)
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** Also look [http://www.pennlive.com/midstate/index.ssf/2012/03/pennsylvania_flu_cases_drop_by.html here] for more dots. And [http://anthraxvaccine.blogspot.com/ here] too.
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** Keywords: anthrax vaccine, BCTP, ''B. anthracis'', ''B. cereus'', food-grade protein nanoemulsions based drug delivery systems in aerosolized form, nanovaccines, H1N1, cytokine, bioaerosols, antigenic sin, antigenic drift, antigenic shift, immunotoxins, rPA (recombinant '''P'''rotective '''A'''ntigen),
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** [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742988/ A single immunization with a '''dry powder''' anthrax vaccine protects rabbits against lethal aerosol challenge.]
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** 19514852 (pXO1 = conjugative plasmid, 184 kb long)
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** [http://www.uniprot.org/uniprot/P13423 Protective antigen precursor - Bacillus Anthracis]
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* Recombinant H5N1 pandemic flu antigen: Is the repeated exposure to the nanoemulsion-based reagent can induces a immunogenic response mediated by tolerogenic '''dentritic cells''' activation, thus preventing hemagluttinin mutagenesis? Answer: The truth is in [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977862 PMC2977862]...
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** '''Liposome-mediated Dentritic Cells transfection: an orthogonal pathway for (inter-species) gene transfer and drug metabolism using hemogenic proteins (peptides) macrophages? (aka cytokines)'''
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*** Keywords: Google: "transfection epithelial cells"
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[[Image: Liposome.jpg|300px|right|Liposome for Drug Delivery!]]
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[[Category: CanadaInDistressCategory]]
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== Quotes ==
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* "During times of universal deceit, telling the truth becomes a revolutionary act." -- George Orwell (1984)
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* "We have now sunk to a depth at which restatement of the obvious is the first duty of intelligent men." -- George Orwell
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* "We shall defend our island, whatever the cost may be, we shall fight on the beaches, we shall fight on the landing grounds, we shall fight in the fields and in the streets, we shall fight in the hills; we shall never surrender." -- Winston Churchill
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* "It is no use saying, 'We are doing our best.' You have got to succeed in doing what is necessary." -- Winston Churchill
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* "You have enemies? Good. That means you've stood up for something, sometime in your life." -- Winston Churchill
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* "What kind of people do they think we are? Is it possible they do not realize that we shall never cease to persevere against them until they have been taught a lesson which they and the world will never forget?" -- Winston Churchill
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* [http://openwetware.org/images/6/66/Science_in_the_city_2-02.png "All free men, wherever they may live, are citizens of Berlin. And therefore, as a free man, I take pride in the words "Ich bin ein Berliner!" -- John F. Kennedy]
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== Multimedia ==
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* BattellePharma intro movie: http://www.youtube.com/embed/VC5vG_nO0Gk
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* The following clip provides good insights on ultrasonic dispersion of most likely silicon-based nanoparticles (liposomes) for pharmaceutical grade drug delivery: http://www.youtube.com/embed/Ac2s_fiTl0E
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== See also ==
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Biology:
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* [http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/otherendo/pineal.html Pineal Gland and Melatonin]
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* [http://www.chem.ucalgary.ca/courses/351/Carey5th/Ch08/ch8-8.html Solvents Effects]
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* [http://www.medwelljournals.com/fulltext/?doi=javaa.2011.1895.1900 Modes of Action of Probiotics: Recent Developments]
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* Amino acids: 
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** [http://faculty.ccbcmd.edu/courses/bio141/lecguide/unit4/antigens/antigens.html The Adaptive Immune System: Antigens]
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** [http://www.biology.arizona.edu/biochemistry/problem_sets/aa/aa.html The Chemistry of Amino Acids]
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** [http://toxsci.oxfordjournals.org/content/76/1/131/F1.large.jpg Fatty Acid Amide Hydrolase]
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* Genetic acquisitions of synthetic like antigens (ie: vaccine escape evidences)
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** [http://pf11.blogspot.com/2010/03/zoonotic-h9n2-avian-influenza-further.html "The truth is in the sequences."]
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** [http://www.lewrockwell.com/sardi/sardi133.html Why Isn't the H1N1 Pandemic Flu Being Investigated as a Designed Bioweapon?]
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** [http://anthro.palomar.edu/mendel/mendel_3.htm Basic Principles of Genetics: Exceptions to Simple Inheritance] (non-Mendelian inheritance)
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** [http://www.mendeley.com/research/highly-pathogenic-avian-influenza-virus-h5n1-egypt-escapes-vaccineinduced-immunity-confers-clinical-protection-against-heterologous-clade-22-1-egyptian-isolate/ Highly pathogenic avian influenza virus H5N1 from Egypt escapes vaccine-induced immunity but confers clinical protection against a heterologous clade 2.2.1 Egyptian isolate.]
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Peoples:
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* [http://keith.seas.harvard.edu/FICER.html Fund for Innovative Climate and Energy Research]
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* [http://caseclosedbylewweinstein.wordpress.com/2009/06/28/tracking-dr-ivins%E2%80%99-rmr-1029-anthrax-more-questions-for-um-and-lsu-researchers/ tracking Dr. Ivins’ RMR-1029 anthrax; more questions for UM and LSU researchers]
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* [http://cns.miis.edu/wmdjunction/110822_fbi_anthrax.htm New Questions About the FBI's Anthrax Case: Valid Concerns or Red Herring?]
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* [http://usasurvival.org/ck03.25.10.html Obama Obstructs Oversight of FBI in Anthrax Case]
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* [http://killerspray.com/blog?post=Teen_SofiaXenidis_call2_action Sofia Xenidis Testimonial and Call for Actions]
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Wikipedia:
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* [http://en.wikiversity.org/wiki/Introduction_to_psychology/Consciousness Introduction to psychology: Consciousness]
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News and media coverage:
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* [http://www.nature.com/news/remote-controlled-genes-trigger-insulin-production-1.10585 Remote-controlled genes trigger insulin production]
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** [[User:Etienne Robillard|Etienne Robillard]] 07:18, 5 May 2012 (EDT): Whoa, calmodulin mediated signal transduction using fat-soluble nanoparticles aggregating to tumor cells in a "controlled/directed" process using heat/light energy as the master switch for tyrosine kinase II to induce or inhibit (auto)phosphorylation of pTyr residues?
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* [http://www.naturalnews.com/034906_Bill_Gates_geo-engineering_chemtrails.html Bill Gates exposed for funding research, promotion of spraying geo-engineered 'chemtrails' across globe], 2012/02/08
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* [http://www.crainsdetroit.com/article/20110803/FREE/110809957 NanoBio gets license from agency to develop vaccine to fight respiratory syncytial virus infections], 2011/08/03
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* [http://www.sciencedaily.com/releases/2010/09/100930142727.htm Microbes Engineered for Low-Cost Production of '''Anti-Cancer''' Drug, Taxol], 2010
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* [http://www.azonano.com/news.aspx?newsID=15165 GSK and NanoBio Signs Exclusive Over-the-Counter Licensing Agreement for Nanoemulsion Treatment], 2009/12/16
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* [http://www.schizophreniaforum.org/new/detail.asp?id=1413 Does Oxidative Stress Link NMDA and GABA Hypotheses of Schizophrenia?] ([http://www.sciencedirect.com/science/article/pii/S0304394008010197 Study]), 2007/12/09
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* [http://phys.org/news7764.html Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates], 2005/11/01
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* [http://www.thefreelibrary.com/BattellePharma+to+Present+At+Respiratory+Drug+Delivery+VIII...-a085494227 BattellePharma to Present At Respiratory Drug Delivery VIII Conference.], 2002/05/07
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* [http://www.nytimes.com/2001/09/04/world/us-germ-warfare-research-pushes-treaty-limits.html U.S. Germ Warfare Research Pushes Treaty Limits], 2001/09/04
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__NOTOC__
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Current revision

Work-in-progress.

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Recent changes


Contents


Hypothesis

1. Unilateral/clandestine solar geoengineering activity is a source of air pollution/particulate matter. (PM2.5)

2. The molecular toxicity of PM2.5 is poorly understood.

3. The nanotoxicity, neurotoxicity, and genotoxicity of PM2.5 exposure on human health requires further investigations.

4. The differential effects of chronic PM2.5 exposure on the neuroimmune system, lung/brain axis, chronic inflammation, and neurodegenerative disorders (Alzheimer, Parkinson) requires additional research. [1]

5. MAC1/Glutaminase activation is implicated in the microglia-mediated dopaminergic neurotoxicity of PM2.5. [2][3]

Differential effects of nanoparticles translocation

Cardiovascular system

  • Effects of particulate matter (PM2.5) air pollution on cardiovascular diseases. [4]
    • Increase in blood pressure (hypertension) [5]
    • The association of annual air pollution exposure with blood pressure among patients with sleep-disordered breathing. [6]
  • Dysregulation of miRNA expression levels. [7]

Central nervous system

  • Alzheimer disease [8][2]
  • Parkinson disease [2]
  • PM2.5 exposure may cause chronic neuroinflammation and oxidative stress. [9][3][10][11]
  • PM2.5 exposure may induce selective neurotoxicity through glutamatergic signaling and increase NMDA-induced excitotoxicity. [3][12]
  • Cyclooxygenase-2, interleukin-1beta, and CD14 signaling upregulation. [13]
  • Microglia-mediated dopaminergic neurotoxicity (Reactive microgliosis). [2]

Endocrine system

  • Decrease of serum testosterone levels [14]
  • Increase of serum estradiol levels [14]
  • Autoimmune disorders [15]

Limbic system

  • Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus. [16]

Lymphatic system

  • Lipid peroxidation and oxidative DNA/RNA damage. [17]

Respiratory system

  • AECOPD [9]
  • Lung cancer [18]

Nanotoxicity of functionalized nanoparticles

Notes

Resources

Keywords

aerosol, bioaerosol, functionalized nanoparticles, aluminium oxide, particulate matter, PM2.5, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium, gold, microglia, MAC1, monodisperse aerosol, condensation, drug delivery

Support this project

This project is entirely financed by personal donations. To support this project, use the following link to donate money via Paypal: https://paypal.me/EtienneRobillard

References

  1. https://www.ncbi.nlm.nih.gov/pubmed/15061611 [Gilmour-2004]
    Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion.

  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660420/ [Levesque-2013]
    The Role of MAC1 in Diesel Exhaust Particle-induced Microglial Activation and Loss of Dopaminergic Neuron Function

  3. https://www.ncbi.nlm.nih.gov/pubmed/25913161 [Liu-2015]
    Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation.

  4. https://www.ncbi.nlm.nih.gov/pubmed/20458016 [Brook-2010]
    Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association.

  5. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402685/ [Balasubramanian-2013]
    Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats.

  6. https://www.ncbi.nlm.nih.gov/pubmed/26580727 [Liu-2016]
    The association of annual air pollution exposure with blood pressure among patients with sleep-disordered breathing.

  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782360/ [Lu-2015]
    Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals

  8. https://www.ncbi.nlm.nih.gov/pubmed/25310992 [Jung-2015]
    Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan.

  9. http://journal.frontiersin.org/article/10.3389/fphys.2015.00294/full [Lei-2015]
    Fine particulate matter in acute exacerbation of COPD.

  10. https://www.ncbi.nlm.nih.gov/pubmed/21506876 [Riva-2011]
    Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice.

  11. https://www.ncbi.nlm.nih.gov/pubmed/21561831 [Levesque-2011]
    Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity.

  12. https://www.ncbi.nlm.nih.gov/pubmed/21724521 [Morgan-2011]
    Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro.

  13. https://www.ncbi.nlm.nih.gov/pubmed/18349428 [Solt-2008]
    Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults.

  14. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759935/ [Lavicoli-2013]
    The Effects of Nanomaterials as Endocrine Disruptors.

  15. https://www.ncbi.nlm.nih.gov/pubmed/25988990 [Bernatsky-2016]
    Fine particulate air pollution, nitrogen dioxide, and systemic autoimmune rheumatic disease in Calgary, Alberta.

  16. https://www.ncbi.nlm.nih.gov/pubmed/27539004 [Chao-2017]
    Exposure to PM2.5 causes genetic changes in fetal rat cerebral cortex and hippocampus.

  17. https://www.ncbi.nlm.nih.gov/pubmed/27321041 [Ambroz-2016]
    Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns.

  18. https://www.ncbi.nlm.nih.gov/pubmed/24911630 [Hamra-2014]
    Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis.

  19. http://www.mdpi.com/1660-4601/12/8/9375/htm [Herndon-2015]
    Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health

  20. http://nuclearplanet.com/frontiers1.pdf [Herndon-2016]
    Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification.

  21. http://www.tandfonline.com/doi/abs/10.1080/027868201753306714 [Cheng-2010]
    Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels.

License

Copyright (C) 2012-2017 Etienne Robillard

Permission is granted to copy, distribute and/or modify this document Under the terms of the GNU Free Documentation License, Version 1.3 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled "GNU Free Documentation License".



See you in space cowboy

"I am free, no matter what rules surround me. If I find them tolerable, I tolerate them; if I find them too obnoxious, I break them. I am free because I know that I alone am morally responsible for everything I do." -Robert A. Heinlein
"The essence of the independent mind lies not in what it thinks, but in how it thinks." ― Christopher Hitchens
"Now let us consider another kind of drug – still undiscovered, but probably just around the corner – a drug capable of making people feel happy in situations where they would normally feel miserable. Such a drug would be a blessing, but a blessing fraught with grave political dangers. By making harmless chemical euphoria freely available, a dictator could reconcile an entire population to a state of affairs to which self-respecting human beings ought not to be reconciled. Despots have always found it necessary to supplement force by political or religious propaganda. In this sense the pen is mightier than the sword. But mightier than either the pen or the sword is the pill. In mental hospitals it has been found that chemical restraint is far more effective than strait jackets or psychiatry. The dictatorships of tomorrow will deprive men of their freedom, but will give them in exchange a happiness none the less real, as a subjective experience, for being chemically induced. The pursuit of happiness is one of the traditional rights of man; unfortunately, the achievement of happiness may turn out to be incompatible with another of man's rights – liberty." - Aldous Huxley
"Under our noses, over our heads, hidden in plain sight..." - Anonymous
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