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| I'll keep important notes about DMSO on this page in free (disorganized) form :
| | == Useful links == |
| | | * http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695195/ |
| == Molecules fact sheet == | | * http://www.ncbi.nlm.nih.gov/pubmed/2237927 (Duke University) |
| | | * http://www.ncbi.nlm.nih.gov/pubmed/10693653 (Michigan) |
| DMSO = Dimethyl sulfoxide (C2H6OS)
| | * http://www.ncbi.nlm.nih.gov/pubmed/11372645 (Michigan) |
| | | * [http://brenda-enzymes.org/php/result_flat.php4?ecno=3.1.1.8 EC 3.1.1.8] |
| DMS = Dimethyl sulfide (C2H6S)
| | * http://pmep.cce.cornell.edu/profiles/extoxnet/TIB/cholinesterase.html |
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| DMSO melting/freezing point in Celcius = 18.4 degree C.
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| DMSO molar mass: 78.13 g mol−1
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| == Formulas ==
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| Phase 1. Liquid to gas oxidation of DMS to DMSO (redox reaction):
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| 1. C2H6S (62.13g/mol) + OH- (16g/mol) -> C2H6OS (78.13g/mol)
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| Phase 2. Gas to liquid Cloud Condensation Nuclei (reversible equilibrium) (XXX)
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| 2. C2H6OS + H2O <=> H3O+ + C2H6S
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| == Notes ==
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| === Acidity in DMSO based buffer solution ===
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| See http://www.chem.wisc.edu/areas/reich/pkatable/
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| === Observed Physiological effects ===
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| 1. Skin rashes and inflammation following initial exposure
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| 2. Penetrates skin tissues and blood/brain cells with chemicals attracted to positively-charged organic Sulfur ion
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| === Endocrine disruption ===
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| Furthermore chronic or prolonged DMSO exposure may also trigger multiple cellular/molecular level effects
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| on the endocrinian system, including:
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| 1. Trigger mild to moderate immune reaction
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| 2. Depletes blood platelet production as result from prolonged exposure to pathogens and weaken immune system (bacterias, virus, etc)
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| 2. Light memory and cognitive impairments (Fatigue, mild discomfort, headaches, migraines, ...)
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| == Frequently Asked Questions (FAQ) ==
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| 1. For starters, let start with a brilliant one-thousand words picture: [http://openwetware.org/images/6/66/Science_in_the_city_2-02.png].
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| 3. Since DMSO is a sulfur-based organic solvent, explain the chain-reactions when i.e Cannabis (CB1) -> GABA -> Anandamide happens, and why this may have extra-pyramidal effects (i.e delayed toxicity) on the central-nervous system (CNS). (Note: I used Cannabis in this example but feel free | |
| to consider other pharmacological molecules as well..).
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| 4. Why is there a visible white trail on the image above and the direction of the clock points to it ?
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| 5. Any ideas ? :-)
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| 6. Explain in English (or French) the origins of the German word "BACHEM" ?
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| == References ==
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| 1. http://dmso.org/articles/pharmacology/CellularMolecularAspects.pdf
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