User:Tkadm30/Notebook/DHA: Difference between revisions
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=== DHA (docosahexaenoic acid) === | === DHA (docosahexaenoic acid) === | ||
'''Intracellular DHA delivery promote persistent synaptic plasticity and neuroprotection in the hippocampus:''' | '''Intracellular DHA delivery promote persistent synaptic plasticity and neuroprotection in the hippocampus:''' | ||
* BDNF-induced synaptogenesis is enhanced by intracellular DHA delivery to | * BDNF-induced synaptogenesis is enhanced by intracellular DHA delivery to neural stem/progenitor cells | ||
* CREB activation may protect neurons from glutamate excitoxicity and neuroinflammation. | * CREB activation may protect neurons from glutamate excitoxicity and neuroinflammation. | ||
'''DHA increase CREB function by upregulation of mature BDNF (mBDNF) levels:''' | '''DHA increase CREB function by upregulation of mature BDNF (mBDNF) levels:''' | ||
Revision as of 14:14, 12 November 2015
DHA (docosahexaenoic acid)
Intracellular DHA delivery promote persistent synaptic plasticity and neuroprotection in the hippocampus:
- BDNF-induced synaptogenesis is enhanced by intracellular DHA delivery to neural stem/progenitor cells
- CREB activation may protect neurons from glutamate excitoxicity and neuroinflammation.
DHA increase CREB function by upregulation of mature BDNF (mBDNF) levels:
- mBDNF activate the TrkB receptor and decrease the excitability of GABAergic interneurons. PMID
- DHA-induced CREB phosphorylation enhance hippocampal plasticity and LTP through cAMP response element (CRE)-mediated gene induction and PPARs expression. (signal transduction) PMC PMID
Neuroprotective properties of DHA:
- DHA is neuroprotective and controlled by the P2X7 purinoreceptor. PMID
- DHA exert proneurogenic functions on activated microglia cells. PMID
DHEA (N-docosahexaenoyl ethanolamide)
- Ethanolamide metabolite of DHA.
- Derivative of anandamide.
- A synaptogenic endocannabinoid with antiglutamatergic and neuroprotective effects that induce synaptogenesis in vivo. PMC
