User:Tkadm30/Notebook/DHA: Difference between revisions
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=== DHA (docosahexaenoic acid) === | === DHA (docosahexaenoic acid) === | ||
====Intracellular DHA delivery promote homeostatic synaptic plasticity and neuroprotection in the hippocampus by increasing BDNF/CREB signaling==== | ====Intracellular DHA delivery promote homeostatic synaptic plasticity and neuroprotection in the hippocampus by increasing BDNF/CREB/cAMP signaling==== | ||
* BDNF-induced synaptogenesis is enhanced by intracellular DHA delivery to neural stem/progenitor cells (NSPCs) | * BDNF-induced synaptogenesis is enhanced by intracellular DHA delivery to neural stem/progenitor cells (NSPCs) | ||
* Increased CREB function (phosphorylation) may protect neurons from glutamate excitoxicity and neuroinflammation. | * Increased CREB function (phosphorylation) may protect neurons from glutamate excitoxicity and neuroinflammation. | ||
Revision as of 06:39, 2 February 2017
DHA (docosahexaenoic acid)
Intracellular DHA delivery promote homeostatic synaptic plasticity and neuroprotection in the hippocampus by increasing BDNF/CREB/cAMP signaling
- BDNF-induced synaptogenesis is enhanced by intracellular DHA delivery to neural stem/progenitor cells (NSPCs)
- Increased CREB function (phosphorylation) may protect neurons from glutamate excitoxicity and neuroinflammation.
- DHA increase CREB function by upregulation of mature BDNF (mBDNF) levels
- mBDNF transactivate the TrkB receptor and decrease the excitability of GABAergic interneurons. [1]
Neuroprotective properties of DHA
- DHA is neuroprotective and controlled by the P2X7 purinoreceptor. [2]
- DHA exert proneurogenic functions on activated microglia cells. [3]
DHA and vitamin D control of serotonin synthesis
DHEA (N-docosahexaenoyl ethanolamide)
- Ethanolamide metabolite of DHA.
- Derivative of anandamide.
- A synaptogenic endocannabinoid with antiglutamatergic and neuroprotective effects that induce synaptogenesis in vivo. [4]
References
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Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus.
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Purine receptors are required for DHA-mediated neuroprotection against oxygen and glucose deprivation in hippocampal slices.
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Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells.
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Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines.
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Regulation of calcium signalling by docosahexaenoic acid in human T-cells. Implication of CRAC channels.
