User:Tkadm30/Notebook/DHA: Difference between revisions
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* BDNF-induced synaptogenesis is enhanced by intracellular DHA delivery to neural stem/progenitor cells (NSPCs) | * BDNF-induced synaptogenesis is enhanced by intracellular DHA delivery to neural stem/progenitor cells (NSPCs) | ||
* Increased CREB function (phosphorylation) may protect neurons from glutamate excitoxicity and neuroinflammation via phosphorylation of the NMDA receptor. <cite>Paper6</cite> | * Increased CREB function (phosphorylation) may protect neurons from glutamate excitoxicity and neuroinflammation via phosphorylation of the NMDA receptor. <cite>Paper6</cite> | ||
** mBDNF transactivate the TrkB receptor and decrease the excitability of GABAergic interneurons. <cite>Paper1</cite> | ** mBDNF transactivate the TrkB receptor and decrease the excitability of GABAergic interneurons. <cite>Paper1</cite> | ||
Revision as of 06:55, 2 February 2017
DHA (docosahexaenoic acid)
Intracellular DHA delivery promote homeostatic synaptic plasticity and neuroprotection in the hippocampus by increasing cAMP/PKA/CREB signaling
- BDNF-induced synaptogenesis is enhanced by intracellular DHA delivery to neural stem/progenitor cells (NSPCs)
- Increased CREB function (phosphorylation) may protect neurons from glutamate excitoxicity and neuroinflammation via phosphorylation of the NMDA receptor. [1]
- mBDNF transactivate the TrkB receptor and decrease the excitability of GABAergic interneurons. [2]
Neuroprotective properties of DHA
- DHA is neuroprotective and controlled by the P2X7 purinoreceptor. [3]
- DHA exert proneurogenic functions on activated microglia cells. [4]
DHA and vitamin D control of serotonin synthesis
DHEA (N-docosahexaenoyl ethanolamide)
- Ethanolamide metabolite of DHA.
- Derivative of anandamide.
- A synaptogenic endocannabinoid with antiglutamatergic and neuroprotective effects that induce synaptogenesis in vivo. [5]
References
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Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1.
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Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus.
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Purine receptors are required for DHA-mediated neuroprotection against oxygen and glucose deprivation in hippocampal slices.
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Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells.
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Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines.
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Regulation of calcium signalling by docosahexaenoic acid in human T-cells. Implication of CRAC channels.
