User:Tkadm30/Notebook/DHA: Difference between revisions
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* Derivative of anandamide. | * Derivative of anandamide. | ||
* A synaptogenic endocannabinoid with antiglutamatergic and neuroprotective effects that induce synaptogenesis in vivo. <cite>Paper4</cite> | * A synaptogenic endocannabinoid with antiglutamatergic and neuroprotective effects that induce synaptogenesis in vivo. <cite>Paper4</cite> | ||
=== DHA-5-HT === | |||
* Serotonin conjugate of DHA. <cite>Paper9</cite> | |||
===References=== | ===References=== | ||
<biblio> | <biblio> | ||
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#Paper8 https://www.ncbi.nlm.nih.gov/pubmed/16922818 | #Paper8 https://www.ncbi.nlm.nih.gov/pubmed/16922818 | ||
//Omega-3 fatty acids and hypertension in humans. | //Omega-3 fatty acids and hypertension in humans. | ||
#Paper9 https://www.ncbi.nlm.nih.gov/pubmed/27663185 | |||
//Docosahexaenoyl serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23-IL-17 signaling in macrophages. | |||
</biblio> | </biblio> | ||
Revision as of 14:28, 31 July 2017
DHA (docosahexaenoic acid)
Intracellular DHA delivery promote homeostatic synaptic plasticity and neuroprotection in the hippocampus by increasing cAMP/PKA/CREB signaling
- BDNF-induced synaptogenesis is enhanced by intracellular DHA delivery to neural stem/progenitor cells (NSPCs)
- Increased CREB function (phosphorylation) may protect neurons from glutamate excitoxicity and neuroinflammation via phosphorylation of the NMDA receptor. [1]
- mBDNF transactivate the TrkB receptor and decrease the excitability of GABAergic interneurons. [2]
Neuroprotective properties of DHA
- DHA is neuroprotective and controlled by the P2X7 purinoreceptor. [3]
- DHA exert proneurogenic functions on activated microglia cells. [4]
DHA and vitamin D control of serotonin synthesis
DHEA (N-docosahexaenoyl ethanolamide)
- Ethanolamide metabolite of DHA.
- Derivative of anandamide.
- A synaptogenic endocannabinoid with antiglutamatergic and neuroprotective effects that induce synaptogenesis in vivo. [5]
DHA-5-HT
- Serotonin conjugate of DHA. [6]
References
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Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1.
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Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus.
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Purine receptors are required for DHA-mediated neuroprotection against oxygen and glucose deprivation in hippocampal slices.
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Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells.
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Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines.
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Docosahexaenoyl serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23-IL-17 signaling in macrophages.
-
Regulation of calcium signalling by docosahexaenoic acid in human T-cells. Implication of CRAC channels.
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Effects of Docosahexaenoic Acid on Neurotransmission.
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Omega-3 fatty acids and hypertension in humans.
