User:Etienne Robillard/Notebook/Drospirenone
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* CYP450 mediated [1] (A spironolactone derived alkyloid) | * CYP450 mediated [1] (A spironolactone derived alkyloid) | ||
* optical isomerism (C2) : a HSL (homoserine) lactone derivative ? | * optical isomerism (C2) : a HSL (homoserine) lactone derivative ? | ||
| - | * A high risks of hyperkalemia (K+) was found with long-term use of Yasmin. [http://sante.canoe.ca/drug_info_details.asp?brand_name_id=2052 2] | + | * A high risks of hyperkalemia (K+) was found with long-term use of Yasmin. [[http://sante.canoe.ca/drug_info_details.asp?brand_name_id=2052 2]] |
* Ethics of birth control with chiral Schiff base alkyloids in orthogonal Fmoc-carbonyl nucleophilic catalysis? See [http://en.wikipedia.org/wiki/Grignard_reagent Grignard reagent] . | * Ethics of birth control with chiral Schiff base alkyloids in orthogonal Fmoc-carbonyl nucleophilic catalysis? See [http://en.wikipedia.org/wiki/Grignard_reagent Grignard reagent] . | ||
| - | * Hence, is there a Yb(OTf)3 (diastereoselective) route to remote activation of Fmoc-protected alkylamines via MW catalysis of C(2)-symmetric amines, ie Drospirenone ? | + | * Hence, is there a '''Yb(OTf)3''' (diastereoselective) route to remote activation of Fmoc-protected alkylamines via MW catalysis of C(2)-symmetric amines, ie Drospirenone ? [[http://www.organic-chemistry.org/abstracts/literature/979.shtm 3]] |
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== References == | == References == | ||
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# http://en.wikipedia.org/wiki/Drospirenone | # http://en.wikipedia.org/wiki/Drospirenone | ||
# http://en.wikipedia.org/wiki/Spironolactone | # http://en.wikipedia.org/wiki/Spironolactone | ||
| + | # [http://www.organic-chemistry.org/abstracts/literature/979.shtm Diastereoselective Synthesis of Pyrrolidines via the Yb(OTf)3 Catalyzed Three-Component Reaction of Aldehydes, Amines, and 1,1-Cyclopropanediesters] | ||
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== See also == | == See also == | ||
[[Pyrrolidines]] | [[Pyrrolidines]] | ||
Revision as of 11:57, 4 February 2013
- CYP450 mediated [1] (A spironolactone derived alkyloid)
- optical isomerism (C2) : a HSL (homoserine) lactone derivative ?
- A high risks of hyperkalemia (K+) was found with long-term use of Yasmin. [2]
- Ethics of birth control with chiral Schiff base alkyloids in orthogonal Fmoc-carbonyl nucleophilic catalysis? See Grignard reagent .
- Hence, is there a Yb(OTf)3 (diastereoselective) route to remote activation of Fmoc-protected alkylamines via MW catalysis of C(2)-symmetric amines, ie Drospirenone ? [3]
References
- http://en.wikipedia.org/wiki/Drospirenone
- http://en.wikipedia.org/wiki/Spironolactone
- Diastereoselective Synthesis of Pyrrolidines via the Yb(OTf)3 Catalyzed Three-Component Reaction of Aldehydes, Amines, and 1,1-Cyclopropanediesters
