User:Etienne Robillard/Notebook/Drospirenone

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(Yb(OTf)3-catalyzed synthetic pyrrolidines via aldimine-protected analogs (Drosperinone))
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* optical isomerism (C2) : a HSL (homoserine) lactone derivative ?
* optical isomerism (C2) : a HSL (homoserine) lactone derivative ?
* A high risks of hyperkalemia (K+) was found with long-term use of Yasmin. [[http://sante.canoe.ca/drug_info_details.asp?brand_name_id=2052 2]]
* A high risks of hyperkalemia (K+) was found with long-term use of Yasmin. [[http://sante.canoe.ca/drug_info_details.asp?brand_name_id=2052 2]]
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* Ethics of birth control with chiral Schiff base alkyloids in orthogonal Fmoc-carbonyl nucleophilic catalysis? See [http://en.wikipedia.org/wiki/Grignard_reagent Grignard reagent] .
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* Ethics of birth control with chiral Schiff base alkaloids in orthogonal Fmoc-carbonyl nucleophilic catalysis? See [http://en.wikipedia.org/wiki/Grignard_reagent Grignard reagent] .
=== Yb(OTf)3-catalyzed synthetic pyrrolidines via aldimine-protected analogs (Drosperinone) ===   
=== Yb(OTf)3-catalyzed synthetic pyrrolidines via aldimine-protected analogs (Drosperinone) ===   
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* Hence, is there a '''Yb(OTf)3''' (diastereoselective) route to remote activation of Fmoc-protected [https://en.wikipedia.org/wiki/Alkaloid#Synthesis_of_Schiff_bases alkaloids] via MW catalysis of C(2)-symmetric amines, ie Drospirenone ? [[http://www.organic-chemistry.org/abstracts/literature/979.shtm 3], [http://repository.ias.ac.in/62840/ 4]]
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* Hence, is there a '''Yb(OTf)3''' (diastereoselective) route to remote activation of Fmoc-protected [http://en.wikipedia.org/wiki/Alkaloid#Synthesis_of_Schiff_bases alkaloids] via MW catalysis of C(2)-symmetric amines, ie Drospirenone ? [[http://www.organic-chemistry.org/abstracts/literature/979.shtm 3], [http://repository.ias.ac.in/62840/ 4]]
== References ==
== References ==

Revision as of 20:36, 4 February 2013

  • CYP450 mediated [1] (A spironolactone derived alkyloid)
  • optical isomerism (C2) : a HSL (homoserine) lactone derivative ?
  • A high risks of hyperkalemia (K+) was found with long-term use of Yasmin. [2]
  • Ethics of birth control with chiral Schiff base alkaloids in orthogonal Fmoc-carbonyl nucleophilic catalysis? See Grignard reagent .

Yb(OTf)3-catalyzed synthetic pyrrolidines via aldimine-protected analogs (Drosperinone)

  • Hence, is there a Yb(OTf)3 (diastereoselective) route to remote activation of Fmoc-protected alkaloids via MW catalysis of C(2)-symmetric amines, ie Drospirenone ? [3, 4]

References

  1. http://en.wikipedia.org/wiki/Drospirenone
  2. http://en.wikipedia.org/wiki/Spironolactone
  3. Diastereoselective Synthesis of Pyrrolidines via the Yb(OTf)3 Catalyzed Three-Component Reaction of Aldehydes, Amines, and 1,1-Cyclopropanediesters
  4. http://en.wikipedia.org/wiki/Ketoxime
  5. http://en.wikipedia.org/wiki/Aldimine

See also

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