User:Etienne Robillard/Notebook/Drospirenone
From OpenWetWare
< User:Etienne Robillard | Notebook(Difference between revisions)
(→Yb(OTf)3-catalyzed synthetic pyrrolidines via aldimine-protected analogs (Drosperinone)) |
Current revision (21:36, 4 February 2013) (view source) |
||
| Line 2: | Line 2: | ||
* optical isomerism (C2) : a HSL (homoserine) lactone derivative ? | * optical isomerism (C2) : a HSL (homoserine) lactone derivative ? | ||
* A high risks of hyperkalemia (K+) was found with long-term use of Yasmin. [[http://sante.canoe.ca/drug_info_details.asp?brand_name_id=2052 2]] | * A high risks of hyperkalemia (K+) was found with long-term use of Yasmin. [[http://sante.canoe.ca/drug_info_details.asp?brand_name_id=2052 2]] | ||
| - | * Ethics of birth control with chiral Schiff base | + | * Ethics of birth control with chiral Schiff base alkaloids in orthogonal Fmoc-carbonyl nucleophilic catalysis? See [http://en.wikipedia.org/wiki/Grignard_reagent Grignard reagent] . |
=== Yb(OTf)3-catalyzed synthetic pyrrolidines via aldimine-protected analogs (Drosperinone) === | === Yb(OTf)3-catalyzed synthetic pyrrolidines via aldimine-protected analogs (Drosperinone) === | ||
| - | * Hence, is there a '''Yb(OTf)3''' (diastereoselective) route to remote activation of Fmoc-protected [ | + | * Hence, is there a '''Yb(OTf)3''' (diastereoselective) route to remote activation of Fmoc-protected [http://en.wikipedia.org/wiki/Alkaloid#Synthesis_of_Schiff_bases alkaloids] via MW catalysis of C(2)-symmetric amines, ie Drospirenone ? [[http://www.organic-chemistry.org/abstracts/literature/979.shtm 3], [http://repository.ias.ac.in/62840/ 4]] |
== References == | == References == | ||
Current revision
- CYP450 mediated [1] (A spironolactone derived alkyloid)
- optical isomerism (C2) : a HSL (homoserine) lactone derivative ?
- A high risks of hyperkalemia (K+) was found with long-term use of Yasmin. [2]
- Ethics of birth control with chiral Schiff base alkaloids in orthogonal Fmoc-carbonyl nucleophilic catalysis? See Grignard reagent .
Yb(OTf)3-catalyzed synthetic pyrrolidines via aldimine-protected analogs (Drosperinone)
- Hence, is there a Yb(OTf)3 (diastereoselective) route to remote activation of Fmoc-protected alkaloids via MW catalysis of C(2)-symmetric amines, ie Drospirenone ? [3, 4]
References
- http://en.wikipedia.org/wiki/Drospirenone
- http://en.wikipedia.org/wiki/Spironolactone
- Diastereoselective Synthesis of Pyrrolidines via the Yb(OTf)3 Catalyzed Three-Component Reaction of Aldehydes, Amines, and 1,1-Cyclopropanediesters
- http://en.wikipedia.org/wiki/Ketoxime
- http://en.wikipedia.org/wiki/Aldimine
