User:Tkadm30/Notebook/Drospirenone

• CYP450 mediated [1] (A spironolactone derived alkyloid)
• optical isomerism (C2) : a HSL (homoserine) lactone derivative ?
• A high risks of hyperkalemia (K+) was found with long-term use of Yasmin. [2]
• Ethics of birth control with chiral Schiff base alkaloids in orthogonal Fmoc-carbonyl nucleophilic catalysis? See Grignard reagent .

Yb(OTf)3-catalyzed synthetic pyrrolidines via aldimine-protected analogs (Drosperinone)

• Hence, is there a Yb(OTf)3 (diastereoselective) route to remote activation of Fmoc-protected alkaloids via MW catalysis of C(2)-symmetric amines, ie Drospirenone ? [3, 4]

References

1. http://en.wikipedia.org/wiki/Drospirenone
2. http://en.wikipedia.org/wiki/Spironolactone
3. Diastereoselective Synthesis of Pyrrolidines via the Yb(OTf)3 Catalyzed Three-Component Reaction of Aldehydes, Amines, and 1,1-Cyclopropanediesters
4. http://en.wikipedia.org/wiki/Ketoxime
5. http://en.wikipedia.org/wiki/Aldimine

See also

• Pyrrolidines
• Cyanuric chloride assisted Beckmann reaction