User:Tkadm30/Notebook/Endocannabinoids: Difference between revisions
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=== Hypothesis === | === Hypothesis === | ||
DHA induced FAAH hydrolysis may promote | DHA induced FAAH hydrolysis may promote synaptogenesis via CB1 activation. | ||
=== Model === | === Model === |
Revision as of 07:53, 27 September 2014
Notes
Hypothesis
DHA induced FAAH hydrolysis may promote synaptogenesis via CB1 activation.
Model
- Use omega 3 (DHA) fatty acids as substrate for docosahexaenoylethanolamide (DHEA) hydrolysis
- Protect the hippocampus and neurons from stress induced damage.
Documentation
Protocol:
- http://www.ncbi.nlm.nih.gov/pubmed/23103355
- http://www.ncbi.nlm.nih.gov/pubmed/11470906
- http://www.ncbi.nlm.nih.gov/pubmed/9842734/
- http://www.ncbi.nlm.nih.gov/pubmed/15111006/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253627/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035504/
- http://www.ncbi.nlm.nih.gov/pubmed/22959887
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/
CB1 signaling and memory:
- http://www.ncbi.nlm.nih.gov/pubmed/24648181
- Cannabinoids and hippocampal neurogenesis:
DHA:
Anandamide signaling:
FAAH (fatty acid amide hydrolase):
Introduction to fatty amides:
Keywords
hippocampus, anandamide, FAAH, fatty acids, THC, neurogenesis, synaptogenesis