User:Tkadm30/Notebook/Endocannabinoids: Difference between revisions
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=== Hypothesis === | === Hypothesis === | ||
# DHA may potentiate synaptic plasticity (and cognition) via [http://www.nature.com/mp/journal/v7/n3/full/4000999a.html retrograde CB1 signaling]. | # DHA may potentiate synaptic plasticity (and cognition) via [http://www.nature.com/mp/journal/v7/n3/full/4000999a.html retrograde CB1 signaling]. | ||
## DHA activate the [http://www.genome.jp/dbget-bin/www_bget?hsa:2902+hsa:2903+hsa:2904+hsa:2905+hsa:2906 NMDA receptor] and upregulate the release of glutamate | ## DHA activate the [http://www.genome.jp/dbget-bin/www_bget?hsa:2902+hsa:2903+hsa:2904+hsa:2905+hsa:2906 NMDA receptor] and upregulate the release of glutamate. [http://www.ncbi.nlm.nih.gov/pubmed/19682204 1] | ||
## Hippocampal CA3 synapses facilitate synaptic plasticity, thus learning is enhanced. [http://cercor.oxfordjournals.org/content/21/11/2442.full 1] | |||
### Induction of LTP. ([http://www.genome.jp/kegg-bin/show_pathway?hsa04720+2902 Pathway]) | ### Induction of LTP. ([http://www.genome.jp/kegg-bin/show_pathway?hsa04720+2902 Pathway]) | ||
# Synaptic activation of GABA(B) receptor by endocannabinoids promotes synaptic function and learning. (activity-dependent synaptogenesis) | # Synaptic activation of GABA(B) receptor by endocannabinoids promotes synaptic function and learning. (activity-dependent synaptogenesis) |
Revision as of 05:34, 21 October 2014
Introduction
Notes
Hypothesis
- DHA may potentiate synaptic plasticity (and cognition) via retrograde CB1 signaling.
- DHA activate the NMDA receptor and upregulate the release of glutamate. 1
- Hippocampal CA3 synapses facilitate synaptic plasticity, thus learning is enhanced. 1
- Induction of LTP. (Pathway)
- Synaptic activation of GABA(B) receptor by endocannabinoids promotes synaptic function and learning. (activity-dependent synaptogenesis)
Model
- The Promoter: omega 3 (fish oil supplement) fatty acids
- DHA (docosahexaenoic acid) conjugate (in the hippocampus?) is docosahexaenoyl ethanolamide (DHEA).
- The Wet Blanket:
- Role: Protect the hippocampus and neurons from glutamate excitoxicity.
- CB1: A synaptogenic receptor? (most likely) 1 2 3
- The Vector:
- FAAH/anandamide hydrolysis of DHEA (a endocannabinoid like molecule)
Documentation
Protocol:
- http://www.ncbi.nlm.nih.gov/pubmed/23103355
- http://www.ncbi.nlm.nih.gov/pubmed/11470906
- http://www.ncbi.nlm.nih.gov/pubmed/9842734/
- http://www.ncbi.nlm.nih.gov/pubmed/15111006/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253627/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035504/
- http://www.ncbi.nlm.nih.gov/pubmed/22959887
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/
- http://www.ncbi.nlm.nih.gov/pubmed/21288475
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661034/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773444/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687658/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769341/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160357/
Cannabinoids and hippocampal neurogenesis:
- http://www.truthonpot.com/2013/07/13/scientists-discover-another-way-marijuana-helps-the-brain-grow/
DHA:
Anandamide signaling:
FAAH (fatty acid amide hydrolase):
Introduction to fatty amides:
Synaptic Plasticity:
Keywords
hippocampus, anandamide, FAAH, fatty acids, THC, neurogenesis, synaptogenesis