User:Tkadm30/Notebook/Endocannabinoids: Difference between revisions

Revision as of 05:43, 21 October 2014

DHA may potentiate synaptic plasticity (and cognition) via retrograde CB1 signaling.
1. DHA activate the NMDA receptor and upregulate the release of glutamate. 1
2. Hippocampal CA3 synapses facilitate synaptic plasticity, thus learning is enhanced. 1
  1. Induction of Long-Term Potentiation (LTP or Persistent synaptic plasticity). (Pathway)
Synaptic activation of GABA(B) receptor by endocannabinoids promotes synaptic function and learning. (activity-dependent synaptogenesis)

The Promoter: omega 3 (fish oil supplement) fatty acids
1. DHA (docosahexaenoic acid) conjugate (in the hippocampus?) is docosahexaenoyl ethanolamide (DHEA).
The Wet Blanket:
1. Role: Protect the hippocampus and neurons from glutamate excitoxicity.
2. CB1: A synaptogenic receptor? (most likely) 1 2 3
The Vector:
1. FAAH/anandamide hydrolysis of DHEA (a endocannabinoid like molecule)

Protocol:

Cannabinoids and hippocampal neurogenesis:

DHA:

Anandamide signaling:

FAAH (fatty acid amide hydrolase):

Introduction to fatty amides:

Synaptic Plasticity:

hippocampus, anandamide, FAAH, fatty acids, THC, neurogenesis, synaptogenesis

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 ## DHA activate the [http://www.genome.jp/dbget-bin/www_bget?hsa:2902+hsa:2903+hsa:2904+hsa:2905+hsa:2906 NMDA  receptor] and upregulate the release of glutamate. [http://www.ncbi.nlm.nih.gov/pubmed/19682204 1]
 ## Hippocampal CA3 synapses facilitate synaptic plasticity, thus learning is enhanced. [http://cercor.oxfordjournals.org/content/21/11/2442.full 1]
-### Induction of LTP. ([http://www.genome.jp/kegg-bin/show_pathway?hsa04720+2902 Pathway])
+### Induction of Long-Term Potentiation (LTP or '''Persistent synaptic plasticity'''). ([http://www.genome.jp/kegg-bin/show_pathway?hsa04720+2902 Pathway])
 # Synaptic activation of GABA(B) receptor by endocannabinoids promotes synaptic function and learning. (activity-dependent synaptogenesis)