User:Tkadm30/Notebook/Endocannabinoids

Notes

Hypothesis

1. DHA may potentiate synaptic plasticity (and cognition) via retrograde CB1 signaling.
   1. DHA activate the NMDA receptor and upregulate the release of glutamate. 1
   2. Hippocampal CA3 synapses facilitate synaptic plasticity, thus learning is enhanced. 1
      1. Induction of Long-Term Potentiation/Persistent synaptic plasticity (LTP). (Pathway)
2. Synaptic activation of GABA(B) receptor by endocannabinoids promotes synaptic function and learning. (activity-dependent synaptogenesis)

Model

1. The Promoter: omega 3 (fish oil supplement) fatty acids
   1. DHA (docosahexaenoic acid) conjugate (in the hippocampus?) is docosahexaenoyl ethanolamide (DHEA).
2. The Wet Blanket:
   1. Role: Protect the hippocampus and neurons from glutamate excitoxicity.
   2. CB1: A synaptogenic receptor? (most likely) 1 2 3
3. The Vector:
   1. FAAH/anandamide hydrolysis of DHEA (a endocannabinoid like molecule)

Documentation

Protocol:

• http://www.ncbi.nlm.nih.gov/pubmed/23103355
• http://www.ncbi.nlm.nih.gov/pubmed/11470906
• http://www.ncbi.nlm.nih.gov/pubmed/9842734/
• http://www.ncbi.nlm.nih.gov/pubmed/15111006/
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253627/
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035504/
• http://www.ncbi.nlm.nih.gov/pubmed/22959887
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/
• http://www.ncbi.nlm.nih.gov/pubmed/21288475
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661034/
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773444/
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687658/
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769341/
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160357/
• http://www.ncbi.nlm.nih.gov/pubmed/23426383
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574086/

Cannabinoids and hippocampal neurogenesis:

• http://www.truthonpot.com/2013/07/13/scientists-discover-another-way-marijuana-helps-the-brain-grow/

DHA:

• http://www.ncbi.nlm.nih.gov/pubmed/19682204

Anandamide signaling:

• http://www.hindawi.com/journals/ije/2013/361895/

FAAH (fatty acid amide hydrolase):

• http://www.brenda-enzymes.org/php/result_flat.php4?ecno=3.5.1.99

Introduction to fatty amides:

• http://lipidlibrary.aocs.org/Lipids/amides/index.htm

Synaptic Plasticity:

• http://neuroscience.uth.tmc.edu/s1/chapter07.html

Keywords

hippocampus, anandamide, FAAH, fatty acids, THC, neurogenesis, synaptogenesis