User:Tkadm30/Notebook/Endocannabinoids: Difference between revisions

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## FAAH/anandamide hydrolysis of DHEA (a endocannabinoid like molecule)
## FAAH/anandamide hydrolysis of DHEA (a endocannabinoid like molecule)
## [http://www.kegg.jp/dbget-bin/www_bget?ko:K04360 TrkB] (2.7.10.1) potentiate GABAergic synaptic activation:   
## [http://www.kegg.jp/dbget-bin/www_bget?ko:K04360 TrkB] (2.7.10.1) potentiate GABAergic synaptic activation:   
### BDNF expression is Ca2+ and CREB dependent [reference]
### BDNF expression is Ca2+ and CREB dependent <cite>ref6</cite>


=== Documentation ===
=== Documentation ===

Revision as of 06:15, 25 October 2014

Introduction

Notes

Hypothesis

  1. DHA may potentiate synaptic plasticity (and cognition) via retrograde CB1 signaling.
    1. DHA activate the NMDA receptor and upregulate the release of glutamate. 1
    2. Hippocampal CA3 synapses facilitate synaptic plasticity, thus learning is enhanced. 2
      1. Induction of Long-Term Potentiation/Persistent synaptic plasticity (LTP). (Pathway)
  2. Synaptic activation of neurotrophic GABA(B) receptor by endocannabinoids (CB1) promote synaptic function and learning. (Is activity-dependent synaptogenesis dependent on BDNF?) 3 4

Model

  1. The Promoter: omega 3 (fish oil supplement) fatty acids
    1. DHA (docosahexaenoic acid) conjugate (in the hippocampus?) is docosahexaenoyl ethanolamide (DHEA).
  2. The Wet Blanket:
    1. Role: Protect the hippocampus and neurons from glutamate excitoxicity.
    2. CB1: A synaptogenic receptor? (most likely) 5
  3. The Vector:
    1. FAAH/anandamide hydrolysis of DHEA (a endocannabinoid like molecule)
    2. TrkB (2.7.10.1) potentiate GABAergic synaptic activation:
      1. BDNF expression is Ca2+ and CREB dependent [1]

Documentation

Protocol:

Cannabinoids and hippocampal neurogenesis:

DHA:

Anandamide signaling:

FAAH (fatty acid amide hydrolase):

Introduction to fatty amides:

Synaptic Plasticity:

Keywords

hippocampus, anandamide, FAAH, DHA, THC, neurogenesis, synaptogenesis, GABA, synaptamide

References

  1. Chen AI, Nguyen CN, Copenhagen DR, Badurek S, Minichiello L, Ranscht B, and Reichardt LF. TrkB (tropomyosin-related kinase B) controls the assembly and maintenance of GABAergic synapses in the cerebellar cortex. J Neurosci. 2011 Feb 23;31(8):2769-80. DOI:10.1523/JNEUROSCI.4991-10.2011 | PubMed ID:21414899 | HubMed [ref6]
  2. Cao D, Kevala K, Kim J, Moon HS, Jun SB, Lovinger D, and Kim HY. Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. J Neurochem. 2009 Oct;111(2):510-21. DOI:10.1111/j.1471-4159.2009.06335.x | PubMed ID:19682204 | HubMed [ref1]
  3. Hagena H and Manahan-Vaughan D. Learning-facilitated synaptic plasticity at CA3 mossy fiber and commissural-associational synapses reveals different roles in information processing. Cereb Cortex. 2011 Nov;21(11):2442-9. DOI:10.1093/cercor/bhq271 | PubMed ID:21493717 | HubMed [ref2]
  4. Adermark L, Talani G, and Lovinger DM. Endocannabinoid-dependent plasticity at GABAergic and glutamatergic synapses in the striatum is regulated by synaptic activity. Eur J Neurosci. 2009 Jan;29(1):32-41. DOI:10.1111/j.1460-9568.2008.06551.x | PubMed ID:19120438 | HubMed [ref3]
  5. Gaiarsa JL and Porcher C. Emerging neurotrophic role of GABAB receptors in neuronal circuit development. Front Cell Neurosci. 2013;7:206. DOI:10.3389/fncel.2013.00206 | PubMed ID:24282395 | HubMed [ref4]
  6. Kim HY, Spector AA, and Xiong ZM. A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):114-20. DOI:10.1016/j.prostaglandins.2011.07.002 | PubMed ID:21810478 | HubMed [ref5]

All Medline abstracts: PubMed | HubMed

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