User:Tkadm30/Notebook/Endocannabinoids

Notes

Hypothesis

1. DHA may potentiate synaptic plasticity (and cognition) via retrograde CB1 signaling.

Model

1. Use omega 3 (DHA) fatty acids as substrate for docosahexaenoylethanolamide (DHEA) hydrolysis
2. Protect the hippocampus and neurons from stress induced damage.
3. CB1: A synaptogenic receptor

Documentation

Protocol:

• http://www.ncbi.nlm.nih.gov/pubmed/23103355
• http://www.ncbi.nlm.nih.gov/pubmed/11470906
• http://www.ncbi.nlm.nih.gov/pubmed/9842734/
• http://www.ncbi.nlm.nih.gov/pubmed/15111006/
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253627/
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035504/
• http://www.ncbi.nlm.nih.gov/pubmed/22959887
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/
• http://www.ncbi.nlm.nih.gov/pubmed/21288475
• Cannabinoids and hippocampal neurogenesis: http://www.truthonpot.com/2013/07/13/scientists-discover-another-way-marijuana-helps-the-brain-grow/
• DHA: http://www.ncbi.nlm.nih.gov/pubmed/19682204
• Anandamide signaling: http://www.hindawi.com/journals/ije/2013/361895/
• FAAH (fatty acid amide hydrolase): http://www.brenda-enzymes.org/php/result_flat.php4?ecno=3.5.1.99
• Introduction to fatty amides: http://lipidlibrary.aocs.org/Lipids/amides/index.htm
• Synaptic Plasticity: http://neuroscience.uth.tmc.edu/s1/chapter07.html

Keywords

hippocampus, anandamide, FAAH, fatty acids, THC, neurogenesis, synaptogenesis