User:Tkadm30/Notebook/Endocannabinoids: Difference between revisions

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== Introduction ==
== Notes ==
== Notes ==


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=== Model ===
=== Model ===
# Use omega 3 (DHA) fatty acids as substrate for docosahexaenoylethanolamide (DHEA) hydrolysis
# The Promoter: omega 3 (fish oil supplement) fatty acids
# Protect the hippocampus and neurons from glutamate excitoxicity.   
## DHA conjugate (in the hippocampus?) is docosahexaenoyl ethanolamide (DHEA)  
# CB1: A synaptogenic receptor; [http://www.alzforum.org/news/research-news/endocannabinoids-wet-blanket-hippocampus-excitement Wet Blanket]; [http://www.ncbi.nlm.nih.gov/pubmed/16908411 PubMed]
# The Wet Blanket:
## Role: Protect the hippocampus and neurons from glutamate excitoxicity.   
## A synaptogenic receptor(?); [http://www.alzforum.org/news/research-news/endocannabinoids-wet-blanket-hippocampus-excitement Link]; [http://www.ncbi.nlm.nih.gov/pubmed/16908411 PubMed]


=== Documentation ===
=== Documentation ===
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=== Keywords ===
=== Keywords ===
hippocampus, anandamide, FAAH, fatty acids, THC, neurogenesis, synaptogenesis
hippocampus, anandamide, FAAH, fatty acids, THC, neurogenesis, synaptogenesis
== References ==

Revision as of 04:42, 9 October 2014

Introduction

Notes

Hypothesis

  1. DHA may potentiate synaptic plasticity (and cognition) via retrograde CB1 signaling.
    1. DHA activate the NMDA (glutamate) receptors and potentiate a peak electrical response.
      1. Induction of LTP.
  2. Synaptic activation of GABA(B) receptor by endocannabinoids promotes synaptic function and learning. (synaptogenesis)

Model

  1. The Promoter: omega 3 (fish oil supplement) fatty acids
    1. DHA conjugate (in the hippocampus?) is docosahexaenoyl ethanolamide (DHEA)
  2. The Wet Blanket:
    1. Role: Protect the hippocampus and neurons from glutamate excitoxicity.
    2. A synaptogenic receptor(?); Link; PubMed

Documentation

Protocol:

Cannabinoids and hippocampal neurogenesis:

DHA:

Anandamide signaling:

FAAH (fatty acid amide hydrolase):

Introduction to fatty amides:

Synaptic Plasticity:

Keywords

hippocampus, anandamide, FAAH, fatty acids, THC, neurogenesis, synaptogenesis

References

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