User:Tkadm30/Notebook/Endocannabinoids: Difference between revisions

Revision as of 05:26, 9 October 2014

DHA may potentiate synaptic plasticity (and cognition) via retrograde CB1 signaling.
1. DHA activate the NMDA (glutamate) receptors and potentiate a peak electrical response.
  1. Induction of LTP.
Synaptic activation of GABA(B) receptor by endocannabinoids promotes synaptic function and learning. (synaptogenesis)

The Promoter: omega 3 (fish oil supplement) fatty acids
1. DHA conjugate (in the hippocampus?) is docosahexaenoyl ethanolamide (DHEA)
The Wet Blanket:
1. Role: Protect the hippocampus and neurons from glutamate excitoxicity.
2. CB1: A synaptogenic receptor? (most likely) 1 2
3. FAAH/anandamide hydrolysis of DHEA (a endocannabinoid like molecule)

Protocol:

Cannabinoids and hippocampal neurogenesis:

DHA:

Anandamide signaling:

FAAH (fatty acid amide hydrolase):

Introduction to fatty amides:

Synaptic Plasticity:

hippocampus, anandamide, FAAH, fatty acids, THC, neurogenesis, synaptogenesis

@@ Line 14: / Line 14: @@
 # The Wet Blanket:
 ## Role: Protect the hippocampus and neurons from [http://www.alzforum.org/news/research-news/endocannabinoids-wet-blanket-hippocampus-excitement glutamate excitoxicity].
-## CB1: A '''synaptogenic''' receptor? (most likely) [http://www.ncbi.nlm.nih.gov/pubmed/16908411 PubMed 1] [http://www.ncbi.nlm.nih.gov/pubmed/23570577 PubMed 2]
+## CB1: A '''synaptogenic''' receptor? (most likely) [http://www.ncbi.nlm.nih.gov/pubmed/16908411 1] [http://www.ncbi.nlm.nih.gov/pubmed/23570577 2]
 ## FAAH/anandamide hydrolysis of DHEA (a endocannabinoid like molecule)