User:Tkadm30/Notebook/Endocannabinoids: Difference between revisions
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# DHA may potentiate synaptic plasticity (and cognition) via [http://www.nature.com/mp/journal/v7/n3/full/4000999a.html retrograde CB1 signaling]. | # DHA may potentiate synaptic plasticity (and cognition) via [http://www.nature.com/mp/journal/v7/n3/full/4000999a.html retrograde CB1 signaling]. | ||
## DHA activate the [http://www.genome.jp/dbget-bin/www_bget?hsa:2902+hsa:2903+hsa:2904+hsa:2905+hsa:2906 NMDA receptor] and upregulate the release of glutamate. [http://www.ncbi.nlm.nih.gov/pubmed/19682204 1] | ## DHA activate the [http://www.genome.jp/dbget-bin/www_bget?hsa:2902+hsa:2903+hsa:2904+hsa:2905+hsa:2906 NMDA receptor] and upregulate the release of glutamate. [http://www.ncbi.nlm.nih.gov/pubmed/19682204 1] | ||
## Hippocampal CA3 synapses facilitate synaptic plasticity, thus learning is enhanced. [http://cercor.oxfordjournals.org/content/21/11/2442.full | ## Hippocampal CA3 synapses facilitate synaptic plasticity, thus learning is enhanced. [http://cercor.oxfordjournals.org/content/21/11/2442.full 2] | ||
### Induction of Long-Term Potentiation/Persistent synaptic plasticity (LTP). ([http://www.genome.jp/kegg-bin/show_pathway?hsa04720+2902 Pathway]) | ### Induction of Long-Term Potentiation/Persistent synaptic plasticity (LTP). ([http://www.genome.jp/kegg-bin/show_pathway?hsa04720+2902 Pathway]) | ||
# Synaptic activation of neurotrophic GABA(B) receptor by endocannabinoids (CB1) promote synaptic function and learning. (Is activity-dependent synaptogenesis dependent on BDNF?) [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661034/ | # Synaptic activation of neurotrophic GABA(B) receptor by endocannabinoids (CB1) promote synaptic function and learning. (Is activity-dependent synaptogenesis dependent on BDNF?) [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661034/ 3] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824957/ 4] | ||
=== Model === | === Model === |
Revision as of 06:22, 23 October 2014
Introduction
Notes
Hypothesis
- DHA may potentiate synaptic plasticity (and cognition) via retrograde CB1 signaling.
- DHA activate the NMDA receptor and upregulate the release of glutamate. 1
- Hippocampal CA3 synapses facilitate synaptic plasticity, thus learning is enhanced. 2
- Induction of Long-Term Potentiation/Persistent synaptic plasticity (LTP). (Pathway)
- Synaptic activation of neurotrophic GABA(B) receptor by endocannabinoids (CB1) promote synaptic function and learning. (Is activity-dependent synaptogenesis dependent on BDNF?) 3 4
Model
- The Promoter: omega 3 (fish oil supplement) fatty acids
- DHA (docosahexaenoic acid) conjugate (in the hippocampus?) is docosahexaenoyl ethanolamide (DHEA).
- The Wet Blanket:
- Role: Protect the hippocampus and neurons from glutamate excitoxicity.
- CB1: A synaptogenic receptor? (most likely) 1 2 3
- The Vector:
- FAAH/anandamide hydrolysis of DHEA (a endocannabinoid like molecule)
- Activation of Ca2+ dependent BDNF via the TrkB pathway
Documentation
Protocol:
- http://www.ncbi.nlm.nih.gov/pubmed/23103355
- http://www.ncbi.nlm.nih.gov/pubmed/11470906
- http://www.ncbi.nlm.nih.gov/pubmed/9842734/
- http://www.ncbi.nlm.nih.gov/pubmed/15111006/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253627/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035504/
- http://www.ncbi.nlm.nih.gov/pubmed/22959887
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/
- http://www.ncbi.nlm.nih.gov/pubmed/21288475
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661034/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773444/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687658/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769341/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160357/
- http://www.ncbi.nlm.nih.gov/pubmed/23426383
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574086/
Cannabinoids and hippocampal neurogenesis:
- http://www.truthonpot.com/2013/07/13/scientists-discover-another-way-marijuana-helps-the-brain-grow/
DHA:
Anandamide signaling:
FAAH (fatty acid amide hydrolase):
Introduction to fatty amides:
Synaptic Plasticity:
Keywords
hippocampus, anandamide, FAAH, fatty acids, THC, neurogenesis, synaptogenesis
References
- Cao D, Kevala K, Kim J, Moon HS, Jun SB, Lovinger D, and Kim HY. Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. J Neurochem. 2009 Oct;111(2):510-21. DOI:10.1111/j.1471-4159.2009.06335.x |
- Hagena H and Manahan-Vaughan D. Learning-facilitated synaptic plasticity at CA3 mossy fiber and commissural-associational synapses reveals different roles in information processing. Cereb Cortex. 2011 Nov;21(11):2442-9. DOI:10.1093/cercor/bhq271 |