User:Tkadm30/Notebook/Endocannabinoids/2-AG

2-arachidonoylglycerol (2-AG)

Synopsis

A novel gliotransmitter controlled by the P2X7 receptor;

2-AG is an endogenous cannabinoid ligand synthesized by diacylglycerol lipase (DGL-α) and phospholipase C (PLC).

Notes

Astrocytes-induced synaptogenesis is enhanced by synaptic retrograde signaling. Thus homeostatic plasticity is increased by endogenous cannabinoid mobilization.

Results

2-AG exert neuroprotective effects on excitotoxic brain injury.

See also

• Phospholipase C Notebook