User:Tkadm30/Notebook/Endocannabinoids/Anandamide: Difference between revisions
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=== References === | === References === | ||
<biblio> | <biblio> | ||
#Paper1 | #Paper1 https://www.ncbi.nlm.nih.gov/pubmed/23372698 | ||
//Type-1 (CB1) Cannabinoid Receptor Promotes Neuronal Differentiation and Maturation of Neural Stem Cells | //Type-1 (CB1) Cannabinoid Receptor Promotes Neuronal Differentiation and Maturation of Neural Stem Cells | ||
#Paper2 | #Paper2 https://www.ncbi.nlm.nih.gov/pubmed/21719698 | ||
//Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide. | //Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide. | ||
</biblio> | </biblio> | ||
Revision as of 04:54, 14 January 2017
Intracellular anandamide trafficking as a promoter of neural differentiation acting through selective CB1 binding
The maturation of neural stem cells via fatty-acid binding proteins (FABPs) signaling may require anandamide as a promoter of CB1-dependent neural differentiation. [1]
Differentiation of hippocampal stem cells with synaptamide is induced by intracellular and selective CB1 receptor binding to anandamide. [2]
Notes
- Allosteric activation of PPAR-RXR heterodimer by anandamide (CB1/TRPV1 receptors) facilitate hippocampal neurogenesis.
- Intracellular FABP5 expression result in anandamide trafficking of heteromeric CB1 receptor.
- Adenosine antagonism potentiate organized trafficking of anandamide via heteromization of CB1 receptor.
See also
References
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Type-1 (CB1) Cannabinoid Receptor Promotes Neuronal Differentiation and Maturation of Neural Stem Cells
-
Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide.
