User:Tkadm30/Notebook/Endocannabinoids/Anandamide: Difference between revisions
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=== Notes === | === Notes === | ||
* Activation of PPAR-RXR heterodimer by anandamide (CB1 receptor) facilitate neural differentiation. | * Activation of PPAR-RXR heterodimer by anandamide (CB1/TRPV1 receptor) facilitate neural differentiation. | ||
* FABP5 expression result in anandamide trafficking of heteromeric CB1 receptor. | * FABP5 expression result in anandamide trafficking of heteromeric CB1 receptor. | ||
Revision as of 08:16, 11 November 2015
Intracellular anandamide trafficking as a promoter of neural differentiation
Background: DHA-induced programming of neural stem cells into mature neurons through fatty-acid binding proteins (FABPs) transport of arachidonic acid may require anandamide as a promoter of neural differentiation.
Introduction: Programming hippocampal stem cells with synaptamide to induce hippocampal neurogenesis as an effect of endocannabinoid-mediated neuroprotection.
Notes
- Activation of PPAR-RXR heterodimer by anandamide (CB1/TRPV1 receptor) facilitate neural differentiation.
- FABP5 expression result in anandamide trafficking of heteromeric CB1 receptor.
See also
References
- Compagnucci C, Di Siena S, Bustamante MB, Di Giacomo D, Di Tommaso M, Maccarrone M, Grimaldi P, and Sette C. Type-1 (CB1) cannabinoid receptor promotes neuronal differentiation and maturation of neural stem cells. PLoS One. 2013;8(1):e54271. DOI:10.1371/journal.pone.0054271 |
Type-1 (CB1) Cannabinoid Receptor Promotes Neuronal Differentiation and Maturation of Neural Stem Cells
