User:Tkadm30/Notebook/Endocannabinoids/Anandamide: Difference between revisions
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=== Intracellular anandamide trafficking as a promoter of neural differentiation === | === Intracellular anandamide trafficking as a promoter of neural differentiation acting through selective CB1 binding === | ||
Background: | Background: |
Revision as of 08:55, 16 November 2015
Intracellular anandamide trafficking as a promoter of neural differentiation acting through selective CB1 binding
Background: DHA-induced programming of neural stem cells into mature neurons through fatty-acid binding proteins (FABPs) transport of arachidonic acid may require anandamide as a promoter of CB1-dependent neural differentiation.
Introduction: Programming hippocampal stem cells with synaptamide to induce hippocampal neurogenesis as an effect of endocannabinoid-mediated neuroprotection is induced by intracellular CB1 receptor binding to anandamide.
Notes
- Allosteric activation of PPAR-RXR heterodimer by anandamide (CB1/TRPV1 receptor) facilitate neural differentiation.
- Intracellular FABP5 expression result in anandamide trafficking of heteromeric CB1 receptor.
See also
References
- Compagnucci C, Di Siena S, Bustamante MB, Di Giacomo D, Di Tommaso M, Maccarrone M, Grimaldi P, and Sette C. Type-1 (CB1) cannabinoid receptor promotes neuronal differentiation and maturation of neural stem cells. PLoS One. 2013;8(1):e54271. DOI:10.1371/journal.pone.0054271 |
Type-1 (CB1) Cannabinoid Receptor Promotes Neuronal Differentiation and Maturation of Neural Stem Cells
- Brailoiu GC, Oprea TI, Zhao P, Abood ME, and Brailoiu E. Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide. J Biol Chem. 2011 Aug 19;286(33):29166-29174. DOI:10.1074/jbc.M110.217463 |
Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide.