User:Tkadm30/Notebook/Endocannabinoids/Anandamide

Intracellular anandamide trafficking as a promoter of neural differentiation acting through selective CB1 binding

Background: DHA-induced programming of neural stem cells into mature neurons through fatty-acid binding proteins (FABPs) transport of arachidonic acid may require anandamide as a promoter of CB1-dependent neural differentiation. [1]

Introduction: Programming hippocampal stem cells with synaptamide to induce hippocampal neurogenesis as an effect of endocannabinoid-mediated neuroprotection is induced by intracellular CB1 receptor binding to anandamide. [2]

Notes

• Allosteric activation of PPAR-RXR heterodimer by anandamide (CB1/TRPV1 receptors) facilitate hippocampal neurogenesis.
• Intracellular FABP5 expression result in anandamide trafficking of heteromeric CB1 receptor.

See also

• TRPV1 Notebook

References

1. Compagnucci C, Di Siena S, Bustamante MB, Di Giacomo D, Di Tommaso M, Maccarrone M, Grimaldi P, and Sette C. Type-1 (CB1) cannabinoid receptor promotes neuronal differentiation and maturation of neural stem cells. PLoS One. 2013;8(1):e54271. DOI:10.1371/journal.pone.0054271 |

   Type-1 (CB1) Cannabinoid Receptor Promotes Neuronal Differentiation and Maturation of Neural Stem Cells

2. Brailoiu GC, Oprea TI, Zhao P, Abood ME, and Brailoiu E. Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide. J Biol Chem. 2011 Aug 19;286(33):29166-29174. DOI:10.1074/jbc.M110.217463 |

   Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide.