User:Tkadm30/Notebook/Endocannabinoids/Anandamide: Difference between revisions

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=== Intracellular anandamide trafficking as a promoter of neural differentiation acting through selective CB1 binding ===
=== Intracellular anandamide trafficking as a promoter of neural differentiation acting through selective CB1 binding ===
The maturation of neural stem cells via fatty-acid binding proteins (FABPs) signaling
The maturation and differentiation of neural stem cells via fatty-acid binding proteins (FABPs) signaling
may require anandamide as a promoter of CB1-dependent neural differentiation. <cite>Paper1</cite>
may require anandamide as a promoter of CB1-dependent neurogenesis. <cite>Paper1</cite>


Differentiation of hippocampal stem cells with synaptamide is induced by intracellular and selective CB1 receptor binding to anandamide. <cite>Paper2</cite>
Differentiation of hippocampal stem cells with synaptamide is induced by intracellular and selective CB1 receptor binding to anandamide. <cite>Paper2</cite>

Revision as of 03:49, 3 April 2017

Intracellular anandamide trafficking as a promoter of neural differentiation acting through selective CB1 binding

The maturation and differentiation of neural stem cells via fatty-acid binding proteins (FABPs) signaling may require anandamide as a promoter of CB1-dependent neurogenesis. [1]

Differentiation of hippocampal stem cells with synaptamide is induced by intracellular and selective CB1 receptor binding to anandamide. [2]

Notes

  • Allosteric activation of PPAR-RXR heterodimer by anandamide (CB1/TRPV1 receptors) facilitate hippocampal neurogenesis.
  • Intracellular FABP5 expression result in anandamide trafficking of heteromeric CB1 receptor.
  • Adenosine antagonism potentiate organized trafficking of anandamide via heteromization of CB1 receptor.
  • Anandamide biosynthesis enhances diuresis. [3]

See also

References

  1. https://www.ncbi.nlm.nih.gov/pubmed/23372698

    [Paper1]

    Type-1 (CB1) Cannabinoid Receptor Promotes Neuronal Differentiation and Maturation of Neural Stem Cells

  2. https://www.ncbi.nlm.nih.gov/pubmed/21719698

    [Paper2]

    Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide.

  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533417/

    [Paper3]

    Diuretic Effects of Cannabinoids

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