User:Tkadm30/Notebook/Endocannabinoids/Synopsis: Difference between revisions
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== Synopsis == | == Synopsis == | ||
Hacking retrograde anandamide signaling | |||
=== Brainstorming === | === Brainstorming === | ||
* Key concept 1: Retrograde anandamide trafficking with dopamine conjugate of DHA may induce selective GPCR | * Key concept 1: Retrograde anandamide trafficking with dopamine conjugate of DHA may induce selective GPCR receptor heteromerization. | ||
* Key concept 2: Microglial Neuroprotection! | * Key concept 2: Microglial Neuroprotection! | ||
* Key concept 3: CREB phosphorylation | * Key concept 3: CREB phosphorylation | ||
* Key concept 4: BDNF expression, a biomarker for learning-dependent synapse formation. <cite>Parkhurst-2013</cite> | * Key concept 4: BDNF expression, a biomarker for learning-dependent synapse formation. (synaptogenesis) <cite>Parkhurst-2013</cite> | ||
=== Synaptogenic endocannabinoids === | === Synaptogenic endocannabinoids === | ||
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* DHA supplementation improves mitochondrial function and neuronal survival (homeostasis). <cite>Stanley-2012</cite> | * DHA supplementation improves mitochondrial function and neuronal survival (homeostasis). <cite>Stanley-2012</cite> | ||
* Anti-proliferative effects of DHEA on prostate cancer cell lines. <cite>Website2</cite> | * Anti-proliferative effects of DHEA on prostate cancer cell lines. <cite>Website2</cite> | ||
=== Microglial activation === | |||
* Inhibitory effect of the CB2 receptor on monocyte subpopulations and microglial activation. <cite>Martin-Moreno-2011</cite> | * Inhibitory effect of the CB2 receptor on monocyte subpopulations and microglial activation. <cite>Martin-Moreno-2011</cite> | ||
** Anti-inflammatory role of anandamide and 2-AG signaling in LPS-stimulated microglial activation of endogenous CB2 receptor. <cite>Website1</cite> | ** Anti-inflammatory role of anandamide and 2-AG signaling in LPS-stimulated microglial activation of endogenous CB2 receptor. <cite>Website1</cite> | ||
Latest revision as of 14:58, 2 October 2018
Synopsis
Hacking retrograde anandamide signaling
Brainstorming
- Key concept 1: Retrograde anandamide trafficking with dopamine conjugate of DHA may induce selective GPCR receptor heteromerization.
- Key concept 2: Microglial Neuroprotection!
- Key concept 3: CREB phosphorylation
- Key concept 4: BDNF expression, a biomarker for learning-dependent synapse formation. (synaptogenesis) [1]
Synaptogenic endocannabinoids
- Intracellular CB1/BDNF signaling mediate on-demand neuroprotection on excitatory (glutamatergic) synapses and in particular astrocytes. [2]
- DHA supplementation improves mitochondrial function and neuronal survival (homeostasis). [3]
- Anti-proliferative effects of DHEA on prostate cancer cell lines. [4]
Microglial activation
- Inhibitory effect of the CB2 receptor on monocyte subpopulations and microglial activation. [5]
- Caffeine is a adenosine antagonist which potentiate CB1 receptor transactivation in the hippocampus PMID PMID
References
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Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.
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CB1 cannabinoid receptors and on-demand defense against excitotoxicity.
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Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids.
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Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease.
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Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation.
