User:Tkadm30/Notebook/Endocannabinoids/Synopsis
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Synopsis
- Stimulation of endocannabinoid transport with polyunsaturated (22:6n-3) fatty acids (DHA, EPA) to target major depressive disorders (MDD) , epilepsy, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), posttraumatic stress disorder (PTSD), Parkinson's disease (PD), and Alzheimer's disease (AD).
- Distribution of endocannabinoid-dependent activity (LTP, synaptogenesis, CREB) in the hippocampus promoting brain-derived neurotrophic factor (BDNF) expression, a biological marker for learning-dependent synapse formation. [1] [2]
- Intracellular CB1 signaling mediate on-demand neuroprotection on excitatory (glutamatergic) synapses and in particular astrocytes. PMID PMID
- DHA supplementation improves mitochondrial function and neuronal survival. PMID
- Identification of a functional GPR40-GPR55 receptor heteromer with potent anti-inflammatory, antiglutamatergic and neuroprotective properties.
- Anti-proliferative effects of DHEA on prostate cancer cell lines. PMC
- A synaptogenic endocannabinoid promoting synaptogenesis.
- Antioxidant (cytoprotective) properties of GPR40-GPR55 heteromer.
- Effects of the endothelial CB2 receptor persistent activation on monocyte subpopulations/microglial activation PMID
- Caffeine is a adenosine antagonist which mediate CB1 receptor activation in the hippocampus PMID PMID
References
- Ludányi A, Hu SS, Yamazaki M, Tanimura A, Piomelli D, Watanabe M, Kano M, Sakimura K, Maglóczky Z, Mackie K, Freund TF, and Katona I. Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus. Neuroscience. 2011 Feb 3;174:50-63. DOI:10.1016/j.neuroscience.2010.10.062 |
Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus.
- Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR 3rd, Lafaille JJ, Hempstead BL, Littman DR, and Gan WB. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. 2013 Dec 19;155(7):1596-609. DOI:10.1016/j.cell.2013.11.030 |
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.