User:Tkadm30/Notebook/Endocannabinoids/Synopsis: Difference between revisions
From OpenWetWare
No edit summary |
|||
| Line 2: | Line 2: | ||
* Stimulation of endocannabinoid transport with polyunsaturated (22:6n-3) fatty acids (DHA, EPA) to target [https://en.wikipedia.org/wiki/Major_depressive_disorder major depressive disorders] (MDD) , epilepsy, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), posttraumatic stress disorder (PTSD), Parkinson's disease (PD), and Alzheimer's disease (AD). | * Stimulation of endocannabinoid transport with polyunsaturated (22:6n-3) fatty acids (DHA, EPA) to target [https://en.wikipedia.org/wiki/Major_depressive_disorder major depressive disorders] (MDD) , epilepsy, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), posttraumatic stress disorder (PTSD), Parkinson's disease (PD), and Alzheimer's disease (AD). | ||
* Distribution of endocannabinoid-dependent activity (LTP, synaptogenesis, CREB) in the hippocampus promoting brain-derived neurotrophic factor (BDNF) expression, a biological marker for learning-dependent synapse formation. | * Distribution of endocannabinoid-dependent activity (LTP, synaptogenesis, CREB) in the hippocampus promoting brain-derived neurotrophic factor (BDNF) expression, a biological marker for learning-dependent synapse formation. <cite>Ludanyi-2011</cite> [https://www.ncbi.nlm.nih.gov/pubmed/24360280 PMID] | ||
* Intracellular CB1 signaling mediate on-demand neuroprotection on excitatory (glutamatergic) synapses and in particular astrocytes. [https://www.ncbi.nlm.nih.gov/pubmed/21376829 PMID] [https://www.ncbi.nlm.nih.gov/pubmed/14526074 PMID] | * Intracellular CB1 signaling mediate on-demand neuroprotection on excitatory (glutamatergic) synapses and in particular astrocytes. [https://www.ncbi.nlm.nih.gov/pubmed/21376829 PMID] [https://www.ncbi.nlm.nih.gov/pubmed/14526074 PMID] | ||
** DHA supplementation improves mitochondrial function and neuronal survival. [https://www.ncbi.nlm.nih.gov/pubmed/22248591 PMID] | ** DHA supplementation improves mitochondrial function and neuronal survival. [https://www.ncbi.nlm.nih.gov/pubmed/22248591 PMID] | ||
| Line 14: | Line 14: | ||
** CB2 stimulation is proneurogenic on adult hippocampal neurogenesis [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435344/ PMC] | ** CB2 stimulation is proneurogenic on adult hippocampal neurogenesis [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435344/ PMC] | ||
* Caffeine is a adenosine antagonist which mediate CB1 receptor activation in the hippocampus [https://www.ncbi.nlm.nih.gov/pubmed/26065937 PMID] [https://www.ncbi.nlm.nih.gov/pubmed/20573894 PMID] | * Caffeine is a adenosine antagonist which mediate CB1 receptor activation in the hippocampus [https://www.ncbi.nlm.nih.gov/pubmed/26065937 PMID] [https://www.ncbi.nlm.nih.gov/pubmed/20573894 PMID] | ||
==References== | |||
<biblio> | |||
#Ludanyi-2011 pmid=21035522 | |||
//Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus. | |||
</biblio> | |||
Revision as of 05:22, 5 February 2016
Synopsis
- Stimulation of endocannabinoid transport with polyunsaturated (22:6n-3) fatty acids (DHA, EPA) to target major depressive disorders (MDD) , epilepsy, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), posttraumatic stress disorder (PTSD), Parkinson's disease (PD), and Alzheimer's disease (AD).
- Distribution of endocannabinoid-dependent activity (LTP, synaptogenesis, CREB) in the hippocampus promoting brain-derived neurotrophic factor (BDNF) expression, a biological marker for learning-dependent synapse formation. [1] PMID
- Intracellular CB1 signaling mediate on-demand neuroprotection on excitatory (glutamatergic) synapses and in particular astrocytes. PMID PMID
- DHA supplementation improves mitochondrial function and neuronal survival. PMID
- Identification of a functional GPR40-GPR55 receptor heteromer with potent anti-inflammatory, antiglutamatergic and neuroprotective properties.
- Anti-proliferative effects of DHEA on prostate cancer cell lines. PMC
- A synaptogenic endocannabinoid promoting synaptogenesis.
- Antioxidant (cytoprotective) properties of GPR40-GPR55 heteromer.
- Effects of the endothelial CB2 receptor persistent activation on monocyte subpopulations/microglial activation PMID
- Caffeine is a adenosine antagonist which mediate CB1 receptor activation in the hippocampus PMID PMID
References
- Ludányi A, Hu SS, Yamazaki M, Tanimura A, Piomelli D, Watanabe M, Kano M, Sakimura K, Maglóczky Z, Mackie K, Freund TF, and Katona I. Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus. Neuroscience. 2011 Feb 3;174:50-63. DOI:10.1016/j.neuroscience.2010.10.062 |
Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus.
