User:Tkadm30/Notebook/Endocannabinoids/Synopsis: Difference between revisions
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* Stimulation of endocannabinoid transport with polyunsaturated (22:6n-3) fatty acids (DHA, EPA) to target [https://en.wikipedia.org/wiki/Major_depressive_disorder major depressive disorders] (MDD) , epilepsy, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), posttraumatic stress disorder (PTSD), Parkinson's disease (PD), and Alzheimer's disease (AD). | * Stimulation of endocannabinoid transport with polyunsaturated (22:6n-3) fatty acids (DHA, EPA) to target [https://en.wikipedia.org/wiki/Major_depressive_disorder major depressive disorders] (MDD) , epilepsy, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), posttraumatic stress disorder (PTSD), Parkinson's disease (PD), and Alzheimer's disease (AD). | ||
* Identification of CREB phosphorylation in the hippocampus promoting brain-derived neurotrophic factor (BDNF) expression, a molecular marker for learning-dependent synapse formation. <cite>Ludanyi-2011</cite> <cite>Parkhurst-2013</cite> | * Identification of CREB phosphorylation in the hippocampus promoting brain-derived neurotrophic factor (BDNF) expression, a molecular marker for learning-dependent synapse formation. <cite>Ludanyi-2011</cite> <cite>Parkhurst-2013</cite> | ||
* Intracellular CB1 signaling mediate on-demand neuroprotection on excitatory (glutamatergic) synapses and in particular astrocytes. <cite>Marsicano-2003</cite> | * Intracellular CB1/BDNF signaling mediate on-demand neuroprotection on excitatory (glutamatergic) synapses and in particular astrocytes. <cite>Marsicano-2003</cite> | ||
** DHA supplementation improves mitochondrial function and neuronal survival. <cite>Stanley-2012</cite> | ** DHA supplementation improves mitochondrial function and neuronal survival. <cite>Stanley-2012</cite> | ||
* Identification of a functional GPR40-GPR55 receptor heteromer with potent anti-inflammatory, antiglutamatergic and neuroprotective properties. | * Identification of a functional GPR40-GPR55 receptor heteromer with potent anti-inflammatory, antiglutamatergic and neuroprotective properties. | ||
Revision as of 05:43, 2 June 2016
Synopsis
- Stimulation of endocannabinoid transport with polyunsaturated (22:6n-3) fatty acids (DHA, EPA) to target major depressive disorders (MDD) , epilepsy, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), posttraumatic stress disorder (PTSD), Parkinson's disease (PD), and Alzheimer's disease (AD).
- Identification of CREB phosphorylation in the hippocampus promoting brain-derived neurotrophic factor (BDNF) expression, a molecular marker for learning-dependent synapse formation. [1] [2]
- Intracellular CB1/BDNF signaling mediate on-demand neuroprotection on excitatory (glutamatergic) synapses and in particular astrocytes. [3]
- DHA supplementation improves mitochondrial function and neuronal survival. [4]
- Identification of a functional GPR40-GPR55 receptor heteromer with potent anti-inflammatory, antiglutamatergic and neuroprotective properties.
- Anti-proliferative effects of DHEA on prostate cancer cell lines. [5]
- A synaptogenic endocannabinoid promoting synaptogenesis.
- Antioxidant (cytoprotective) properties of GPR40-GPR55 heteromer.
- Effects of the endothelial CB2 receptor persistent activation on monocyte subpopulations/microglial activation. [6]
- Caffeine is a adenosine antagonist which mediate CB1 receptor activation in the hippocampus PMID PMID
References
- Ludányi A, Hu SS, Yamazaki M, Tanimura A, Piomelli D, Watanabe M, Kano M, Sakimura K, Maglóczky Z, Mackie K, Freund TF, and Katona I. Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus. Neuroscience. 2011 Feb 3;174:50-63. DOI:10.1016/j.neuroscience.2010.10.062 |
Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus.
- Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR 3rd, Lafaille JJ, Hempstead BL, Littman DR, and Gan WB. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. 2013 Dec 19;155(7):1596-609. DOI:10.1016/j.cell.2013.11.030 |
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.
- Marsicano G, Goodenough S, Monory K, Hermann H, Eder M, Cannich A, Azad SC, Cascio MG, Gutiérrez SO, van der Stelt M, López-Rodriguez ML, Casanova E, Schütz G, Zieglgänsberger W, Di Marzo V, Behl C, and Lutz B. CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science. 2003 Oct 3;302(5642):84-8. DOI:10.1126/science.1088208 |
CB1 cannabinoid receptors and on-demand defense against excitotoxicity.
- Stanley WC, Khairallah RJ, and Dabkowski ER. Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids. Curr Opin Clin Nutr Metab Care. 2012 Mar;15(2):122-6. DOI:10.1097/MCO.0b013e32834fdaf7 |
Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids.
- Martín-Moreno AM, Reigada D, Ramírez BG, Mechoulam R, Innamorato N, Cuadrado A, and de Ceballos ML. Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease. Mol Pharmacol. 2011 Jun;79(6):964-73. DOI:10.1124/mol.111.071290 |
Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease.
