User:Etienne Robillard/Notebook/Fmoc protected phenoxyalkylamine synthesis

From OpenWetWare

< User:Etienne Robillard | Notebook(Difference between revisions)
Jump to: navigation, search
(Added note to US patent 20100305182)
Current revision (05:37, 30 April 2017) (view source)
(Replacing page with '{{deleteme}}')
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
The purpose of this page is to investigate the design and method of operation of novel psychotropic
+
{{deleteme}}
-
alkylamines and synthesis with Fmoc protected reagents, including primary and secondary amines
+
-
as organocatalysts for development of synthetic pharmaceutical compounds with an aryl moeity, hence
+
-
refered herein as N,N-substituted arylcyclohexylamines.
+
-
 
+
-
=== Microwave-activated peptide synthesis ===
+
-
 
+
-
* NB: the electromagnetic radio-frequency range most typical wireless devices operates under the FCC standard for communication devices is 2.4 ghz.
+
-
* In fact, most peoples are unaware this operating frequency can modulate Fmoc protected oligos by micro-wave thermal irradiation, thus a remote attacker may exploit this unregulated frequency range to trigger Fmoc-SPPS based orthogonal ligations of N-methyl rich peptides. [[http://www.faqs.org/patents/app/20100305182 1]]
+
-
* http://www.pharmainfo.net/reviews/new-era-field-synthetic-chemistry-microwave-assisted-synthesis
+
-
* http://www.dddmag.com/articles/2011/08/microwave-peptide-synthesis
+
-
+
-
=== Keywords ===
+
-
 
+
-
N-Methyl-d-aspartate receptor; PCP binding site; MK-801; Tetrahydroisoquinolines
+
-
 
+
-
=== References ===
+
-
 
+
-
<biblio>
+
-
#Rodriguez-H-2012 pmid=20127857
+
-
#Ludwig-M-Cornelia-E-CE-Hoesl-Klaus-T-KT-Wanner pmid=16675066
+
-
</biblio>
+
-
 
+
-
=== See also ===
+
-
 
+
-
* Lewis Acid Catalysed Pictet Spengler Formation of Substituted 1,2,3,4-Tetrahydroisoquinolines.
+

Current revision

It has been requested that this page be removed with restriction endonucleases.
Other articles for deletion are listed here.
Personal tools