User:Etienne Robillard/Notebook/Isocyanide

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Revision as of 11:39, 6 May 2013

Ugi route to Wilmslow

  1. Step 1: Protonation of the isocyanide carbonyl (C=O) to yield a nucleophilic Schiff base via Hoffman/Ugi reaction: O+2ROH = -RN


  1. Wikipedia
  2. Hoffman1 pmid=16953613
  3. Hoffman2
  4. Hoffman3
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