User:Etienne Robillard/Notebook/NMDA dependent cell adhesion

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== Mo calcium, mo visual hallucinations ==
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{{deleteme}}
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__TOC__
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=== Abstract ===
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An essay on the role of the Integrin beta-3 protein (ITGB3) in Ca2+-dependent orthogonal riboswitches.
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=== Introduction ===
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In the study of calcium-mediated (Ca2+) neuronal receptors (NMDA and GABA mostly), the relevance of Ca2+-dependent ligands (ie: calmodulin)
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may hold important factors in the morphogenesis of psychological brain disorders and the pathogenesis of the Alzheimer disease,
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a important phenotype in the understanding of GPCR-mediated brain mutations. Hence a proper understanding of the [http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=377643#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=354192&ID=377640 polypyrimidine tract binding protein-1 (PTBP1) dependent signaling pathway] may reveal new insights in the functions and features of the integrin beta-3 protein as a cell-adhesive (and voltage-gated!) neural substrate for long-term axon and neuronal growth. [1]
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=== Notes ===
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* A integrin beta3 mutant polypeptide lacking the PTBP1 gene ?
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=== References ===
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# http://www.uniprot.org/uniprot/P20592
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# http://www.uniprot.org/uniprot/P26599
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# http://brenda-enzymes.org/php/result_flat.php4?ecno=2.7.11.1&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0
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# '''ITGB2''' http://www.genome.jp/dbget-bin/www_bget?hsa:3689
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# OMIM (ITGB2): http://omim.org/entry/600065 (note the chromosome location and the annotated phenotype)
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=== Keywords ===
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* Integrins, pyrimidine, glutamine, NMDA, hippocampus, calmodulin, PTBP1
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=== For next time! ===
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* Review and complete wiki class page on [[Integrase]].
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* Review Calcium and GABA signaling? (Hint: Wet blanket for Calcium-mediated glutamine endotoxicity!)
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* beta-amyloids APP - In the synthesis of 1,2,3,4-tetrahydroisoquinolines derivatives via asymmetric PS synthesis, how is beta-linked amyloids (note: For the Alzheimer precursor protein type "APP"  on uniprot) responding to 2.45 GHz electromagnetic waves (2.450 GHz is a typical radio-frequency (RF) signal used in portable human wireless devices; Iphone4-type device; etc) for horn-directed mutagenesis of neuronal X-linked polypeptides/ligands ?
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* Moreover assuming the psychochemical media require a ultra-sound frequency (ie: 2.450 GHz) to INDUCE mRNA-activated polypeptide alkane isomerisation of the PTBP1 genes, how mentally retarded do you estimate a human-made decision must be (IQ) to allow and implement the forced installation of such biological assault devices without the consent and informed judgement into the homes and residences of civilians ?
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=== See also... ===
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* [[User:Etienne_Robillard/Notebook/Rhodopsin]] - Rho/GTPase specific AI inducers: Rhodopsin etc.
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* c-Src specialized kinase (SH2/SH3 domain, PH domain, etc)
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* MAPK <-> c-Src domain interactions and cross-talk, ie integrins mediated cross-talking, see also [[User:Etienne_Robillard/Notebook/EGFR|EGFR]]"
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