User:Etienne Robillard/Notebook/NMDA dependent cell adhesion

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== Mo calcium, mo visual hallucinations ==
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__TOC__
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=== Abstract ===
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An essay on the role of the Integrin beta-3 protein (ITGB3) in Ca2+-dependent orthogonal riboswitches.
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=== Introduction ===
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In the study of calcium-mediated (Ca2+) neuronal receptors (NMDA and GABA mostly), the relevance of Ca2+-dependent ligands (ie: calmodulin)
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may hold important factors in the morphogenesis of psychological brain disorders and the pathogenesis of the Alzheimer disease,
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a important phenotype in the understanding of GPCR-mediated brain mutations. Hence a proper understanding of the [http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=377643#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=354192&ID=377640 polypyrimidine tract binding protein-1 (PTBP1) dependent signaling pathway] may reveal new insights in the functions and features of the integrin beta-3 protein as a cell-adhesive (and voltage-gated!) neural substrate for long-term axon and neuronal growth. [1]
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=== Notes ===
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* A integrin beta3 mutant polypeptide lacking the PTBP1 gene ?
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=== References ===
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# http://www.uniprot.org/uniprot/P20592
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# http://www.uniprot.org/uniprot/P26599
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# http://brenda-enzymes.org/php/result_flat.php4?ecno=2.7.11.1&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0
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# '''ITGB2''' http://www.genome.jp/dbget-bin/www_bget?hsa:3689
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# OMIM (ITGB2): http://omim.org/entry/600065 (note the chromosome location and the annotated phenotype)
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=== Keywords ===
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* Integrins, pyrimidine, glutamine, NMDA, hippocampus, calmodulin, PTBP1, neuropeptides, b-secretase (BACE)
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=== For next time! ===
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* Review and complete wiki class page on [[Integrase]].
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* Review Calcium and GABA signaling? (Hint: Wet blanket for Calcium-mediated glutamine endotoxicity!)
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* beta-amyloids APP - In the synthesis of 1,2,3,4-tetrahydroisoquinolines derivatives via asymmetric PS synthesis, how is beta-linked amyloids (note: For the Alzheimer precursor protein type "APP"  on uniprot) responding to 2.45 GHz electromagnetic waves (2.450 GHz is a typical radio-frequency (RF) signal used in portable human wireless devices; Iphone4-type device; etc) for horn-directed mutagenesis of neuronal X-linked polypeptides/ligands ? -[[User:Etienne_Robillard|ER]]
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* Moreover assuming the psychochemical media require a ultra-sound frequency (ie: 2.450 GHz) to INDUCE mRNA-activated polypeptide alkane isomerisation of the PTBP1 genes, how mentally retarded do you estimate a human-made decision must be (IQ) to allow and implement the forced installation of such biological assault devices without the consent and informed judgement into the homes and residences of civilians ? -[[User:Etienne_Robillard|ER]]
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** '''Important Note: Back in World-war 2, Ziklon-b pellets (Auschwitz) were found to dispense the deadly compound to the prisoneers from the <font color=red>outside</font> of the concentration camps'''. Based on theses evidences, which experimental protocol may you use to measure and verify the risks and effects of cumulative exposure to 1,2,3,4-tetrahydroisoquinolines derivatives ? -[[User:Etienne_Robillard|ER]]
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** Furthermore, based on the evidences correlated to the implementation of such potentially harmful and intrusive technology into unprotected homes (non-ionising EM waves) to human health, do you believe the idea/concept of "smart metering" is an affront to human dignity and thus in direct conflict with the principle of saving lifes  ?  -[[User:Etienne_Robillard|ER]]
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=== See also... ===
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* [[User:Etienne_Robillard/Notebook/Rhodopsin|Rhodopsin]] - Rho/GTPase specific AI inducers: Rhodopsin etc.
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* c-Src specialized kinase (SH2/SH3 domain, PH domain, etc)
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* MAPK <-> c-Src domain interactions and cross-talk, ie integrins mediated cross-talking, see: [[User:Etienne_Robillard/Notebook/EGFR|EGFR]]
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----
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''"Courage is resistance to fear, mastery of fear, not absence of fear."'' -Mark Twain
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''"You will never do anything in this world without courage. It is the greatest quality of the mind next to honor."'' - Aristotle
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''"Success is not final, failure is not fatal: it is the courage to continue that counts."'' -Winston Churchill
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