User:Etienne Robillard/Notebook/NMDA dependent cell adhesion

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== Mo calcium, mo visual hallucinations ==
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{{deleteme}}
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__TOC__
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=== Abstract ===
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An essay on the role of the Integrin beta-3 protein (ITGB3) in Ca2+-dependent orthogonal riboswitches.
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=== Introduction ===
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In the study of calcium-mediated (Ca2+) neuronal receptors (NMDA and GABA mostly), the relevance of Ca2+-dependent ligands (ie: calmodulin)
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may hold important factors in the morphogenesis of psychological brain disorders and the pathogenesis of the Alzheimer disease,
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a important phenotype in the understanding of GPCR-mediated brain mutations. Hence a proper understanding of the [http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=377643#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=354192&ID=377640 polypyrimidine tract binding protein-1 (PTBP1) dependent signaling pathway] may reveal new insights in the functions and features of the integrin beta-3 protein as a cell-adhesive (and voltage-gated!) neural substrate for long-term axon and neuronal growth. [1]
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=== Notes ===
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* <s>A integrin beta3 mutant polypeptide lacking the PTBP1 gene ?</s>
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* A pyrimidine-rich associated polypeptide complex is best known as a "protein".
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* A e.coli K12 derived auxotrophic restriction enzyme system may be the key <font color=red>red</font> <font color=purple>heering</font> in understanding protein over-expression factors in the transcription of mRNA.
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* '''Dude where's my calcium?''': Zinc/Leucine/Glycine/Serine  (Rho, GNAT, etc) -> KEY Calcium/Magnesium (Ca2+/Mg2+) mediated cell adhesion amino acids; phosphatase-like (transferase) family members...
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* Neural (Voltage-gated) ligand expression possible side-effect may include novel psychotic behavior, especially if remotely activated with electromagnetic (RF) signals under 2.45 GHz ? -- Check this.
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* "horn" directed mutagenesis: too difficult to realize in vivo? -- Check this!
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=== Going a bit further... ===
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* Explain dna methylation and role of 30C6HSL (exo-genous) promoters in the upregulation of N-Methyl-D-Aspartate receptor and Calcium channel blockers 
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* summarly define how a calcium channel blocker 'block' (disrupt) GABA receptor from processing <font color=purple>visual signals</font> properly in the fore-brain (ie: hippocampus) through a signal transduction cascade...
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* What is primary difference between a putative and non-putative gene?
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=== References ===
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* Proteins and enzymes:
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# cAMP-dependent protein kinase A (C-alpha): http://www.uniprot.org/uniprot/P17612
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# cAMP-dependent protein kinase A (C-beta) : http://www.uniprot.org/uniprot/P22694
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# Histone-lysine N-methyltransferase (SETD8) http://www.uniprot.org/uniprot/Q9NQR1 [http://omim.org/entry/607240 OMIM]
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# E-cadherin (CDH1) http://www.uniprot.org/uniprot/P12830 [http://omim.org/entry/192090 OMIM]
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* By organism:
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# H. sapiens (EC 2.7.11.1) (PTEN-Induced Putative Kinase 1) http://www.genome.jp/dbget-bin/www_bget?hsa:65018 [http://brenda-enzymes.org/php/result_flat.php4?ecno=2.7.11.1&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0 BRENDA]
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# H. sapiens (EC 2.1.1.43) (SETD8) http://www.genome.jp/dbget-bin/www_bget?hsa:387893
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# H. sapiens ('''ITGB2''') http://www.genome.jp/dbget-bin/www_bget?hsa:3689 [http://omim.org/entry/600065 OMIM] (note the chromosome location and the annotated phenotype)
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=== Keywords ===
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* Integrins, pyrimidine, glutamine, NMDA, hippocampus, calmodulin, PTBP1, neuropeptides, b-secretase (BACE)
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=== For next time! ===
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* Review and complete wiki class page on [[Integrase]].
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* Review Calcium and GABA signaling? (Hint: Wet blanket for Calcium-mediated glutamine excitoxicity!)
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* beta-amyloids APP - In the synthesis of 1,2,3,4-tetrahydroisoquinolines derivatives via asymmetric PS synthesis, how is beta-linked amyloids (note: For the Alzheimer precursor protein type "APP"  on uniprot) responding to 2.45 GHz electromagnetic waves (2.450 GHz is a typical radio-frequency (RF) signal used in portable human wireless devices; Iphone4-type device; etc) for horn-directed mutagenesis of neuronal X-linked polypeptides/ligands ? -[[User:Etienne_Robillard|ER]]
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* Moreover assuming the psychochemical media require a ultra-sound frequency (ie: 2.450 GHz) to INDUCE mRNA-activated polypeptide alkane isomerisation of the PTBP1 genes, how mentally retarded do you estimate a human-made decision must be (IQ) to allow and implement the forced installation of such biological assault devices without the consent and informed judgement into the homes and residences of civilians ? -[[User:Etienne_Robillard|ER]]
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** '''Important Note: Back in World-war 2, Ziklon-b pellets (Auschwitz) were found to dispense the deadly compound to the prisoneers from the <font color=red>outside</font> of the concentration camps'''. Based on theses evidences, which experimental protocol may you use to measure and verify the risks and effects of cumulative exposure to 1,2,3,4-tetrahydroisoquinolines derivatives ? -[[User:Etienne_Robillard|ER]]
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** Furthermore, based on the evidences correlated to the implementation of such potentially harmful and intrusive technology into unprotected homes (non-ionising EM waves) to human health, do you believe the idea/concept of "smart metering" is an affront to human dignity and thus in direct conflict with the principle of saving lifes  ?  -[[User:Etienne_Robillard|ER]]
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* Review this paper [http://aizenmanlab.neurobio.pitt.edu/aizenman_position_files/pdf/ardenkcn.pdf here] about the DNA methylation of neuropeptides with cyanide affects the NMDA receptor.
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** For Acetonitrile based cyanolation reagents, see: [[Acetonitrile]]
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** For simple alcohol-based polypeptide cross-linker reagents (dA), see: [[PVA]] and [[Isopropanol]]
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=== See also... ===
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* [[User:Etienne_Robillard/Notebook/Rhodopsin|Rhodopsin]] - Rho/GTPase specific AI inducers: Rhodopsin etc.
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* c-Src specialized kinase (SH2/SH3 domain, PH domain, etc)
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* MAPK <-> c-Src domain interactions and cross-talk, ie integrins mediated cross-talking, see: [[User:Etienne_Robillard/Notebook/EGFR|EGFR]]
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* http://www.alzforum.org/new/detail.asp?id=2070
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----
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''"Courage is resistance to fear, mastery of fear, not absence of fear."'' -Mark Twain
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''"You will never do anything in this world without courage. It is the greatest quality of the mind next to honor."'' - Aristotle
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''"Success is not final, failure is not fatal: it is the courage to continue that counts."'' -Winston Churchill
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