User:Etienne Robillard/Notebook/NMDA dependent cell adhesion
Mo calcium, mo visual hallucinations
An essay on the role of the Integrin beta-3 protein (ITGB3) in Ca2+-dependent orthogonal riboswitches.
In the study of calcium-mediated (Ca2+) neuronal receptors (NMDA and GABA mostly), the relevance of Ca2+-dependent ligands (ie: calmodulin) may hold important factors in the morphogenesis of psychological brain disorders and the pathogenesis of the Alzheimer disease, a important phenotype in the understanding of GPCR-mediated brain mutations. Hence a proper understanding of the polypyrimidine tract binding protein-1 (PTBP1) dependent signaling pathway may reveal new insights in the functions and features of the integrin beta-3 protein as a cell-adhesive (and voltage-gated!) neural substrate for long-term axon and neuronal growth. 
- ITGB2 http://www.genome.jp/dbget-bin/www_bget?hsa:3689
- OMIM (ITGB2): http://omim.org/entry/600065 (note the chromosome location and the annotated phenotype)
- Integrins, pyrimidine, glutamine, NMDA, hippocampus, calmodulin, PTBP1
For next time!
- Review and complete wiki class page on Integrase.
- Review Calcium and GABA signaling? (Hint: Wet blanket for Calcium-mediated glutamine endotoxicity!)